Reduced Expression of Perlecan in the Aorta of Secondary Hyperparathyroidism Model Rats with Medial Calcification

Background. Vascular calcification is an important complication that worsens the prognosis for dialysis patients, although its detailed molecular mechanisms are still unknown. Methods. We produced a rat model for vascular calcification with hyperphosphatasemia and hyperparathyroidism, performing a 5...

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Veröffentlicht in:	Renal failure 2010-03, Vol.32 (2), p.214-223
Hauptverfasser:	Shibata, Maki, Shigematsu, Takashi, Hatamura, Ikuji, Saji, Fumie, Mune, Sachiko, Kunimoto, Ken, Hanba, Yoshiyuki, Shiizaki, Kazuhiro, Sakaguchi, Toshifumi, Negi, Shigeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Abdominal - metabolism Aorta, Abdominal - pathology Biomarkers - blood Calcinosis - metabolism Calcinosis - pathology Cell Culture Techniques Diet Disease Models, Animal heparan sulfate proteoglycan Heparan Sulfate Proteoglycans - genetics Heparan Sulfate Proteoglycans - metabolism hyperparathyroidism Hyperparathyroidism, Secondary - metabolism Hyperparathyroidism, Secondary - pathology hyperphosphatemia Hyperphosphatemia - metabolism Hyperphosphatemia - pathology Immunohistochemistry Male Microarray Analysis Muscle, Smooth, Vascular - cytology Nephrectomy perlecan Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Risk Factors vascular calcification
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