Determination of Betamethasone Dipropionate and Salicylic Acid in Pharmaceutical Preparations by High-Performance Liquid Chromatography
Abstract The simultaneous determination of betamethasone dipropionate (BD) and salicylic acid (SA) in both ointment and topical solution was developed using high-performance liquid chromatography (HPLC). The method was standardized using a LiChrospher(r) 100 RP-18 (125 × 4 mm, 5 μm) column, acetonit...
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| Veröffentlicht in: | Drug development and industrial pharmacy 1998-01, Vol.24 (6), p.553-555 |
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| creator | Kedor-Hackmann, E. R. M. Gianotto, E. A. S. Santoro, M. I R. M |
| description | Abstract
The simultaneous determination of betamethasone dipropionate (BD) and salicylic acid (SA) in both ointment and topical solution was developed using high-performance liquid chromatography (HPLC). The method was standardized using a LiChrospher(r) 100 RP-18 (125 × 4 mm, 5 μm) column, acetonitrile-tetrahydro-furan-acetic acid 1 % (25:20:55 v/v), apparent pH 3.3, as mobile phase, and UV detection at 254 nm. The peak area response versus concentration was linear in a concentration range from 5.0 to 50.0 μg/ml of BD and from 20.0 to 200.0 μgl ml of SA. The correlation coefficients were 0.9997 for BD and 0.9987 for SA, and the relative standard errors of estimates were 1.38% for BD and 3.27% for SA. The coefficient of variation and the recovery average were, respectively, 0.41-1.15% and 100.09% for BD, and 0.57-0.95% and 99.79% for SA. |
| doi_str_mv | 10.3109/03639049809085657 |
| format | Article |
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The simultaneous determination of betamethasone dipropionate (BD) and salicylic acid (SA) in both ointment and topical solution was developed using high-performance liquid chromatography (HPLC). The method was standardized using a LiChrospher(r) 100 RP-18 (125 × 4 mm, 5 μm) column, acetonitrile-tetrahydro-furan-acetic acid 1 % (25:20:55 v/v), apparent pH 3.3, as mobile phase, and UV detection at 254 nm. The peak area response versus concentration was linear in a concentration range from 5.0 to 50.0 μg/ml of BD and from 20.0 to 200.0 μgl ml of SA. The correlation coefficients were 0.9997 for BD and 0.9987 for SA, and the relative standard errors of estimates were 1.38% for BD and 3.27% for SA. The coefficient of variation and the recovery average were, respectively, 0.41-1.15% and 100.09% for BD, and 0.57-0.95% and 99.79% for SA.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.3109/03639049809085657</identifier><identifier>PMID: 9876622</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Administration, Topical ; Analysis ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - analysis ; Betamethasone - administration & dosage ; Betamethasone - analogs & derivatives ; Betamethasone - analysis ; Biological and medical sciences ; Chemistry, Pharmaceutical ; Chromatography, High Pressure Liquid - methods ; Chromatography, High Pressure Liquid - standards ; Chromatography, High Pressure Liquid - statistics & numerical data ; General pharmacology ; Glucocorticoids ; Humans ; Medical sciences ; Ointments ; Pharmacology. Drug treatments ; Salicylic Acid - administration & dosage ; Salicylic Acid - analysis ; Solutions ; Spectrophotometry, Ultraviolet</subject><ispartof>Drug development and industrial pharmacy, 1998-01, Vol.24 (6), p.553-555</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-67496bb66556e1d31a1862ec719145ed73eb7abb4e9eb160012e2ab4023c26f13</citedby><cites>FETCH-LOGICAL-c430t-67496bb66556e1d31a1862ec719145ed73eb7abb4e9eb160012e2ab4023c26f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/03639049809085657$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/03639049809085657$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2274718$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9876622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kedor-Hackmann, E. R. M.</creatorcontrib><creatorcontrib>Gianotto, E. A. S.</creatorcontrib><creatorcontrib>Santoro, M. I R. M</creatorcontrib><title>Determination of Betamethasone Dipropionate and Salicylic Acid in Pharmaceutical Preparations by High-Performance Liquid Chromatography</title><title>Drug development and industrial pharmacy</title><addtitle>Drug Dev Ind Pharm</addtitle><description>Abstract
The simultaneous determination of betamethasone dipropionate (BD) and salicylic acid (SA) in both ointment and topical solution was developed using high-performance liquid chromatography (HPLC). The method was standardized using a LiChrospher(r) 100 RP-18 (125 × 4 mm, 5 μm) column, acetonitrile-tetrahydro-furan-acetic acid 1 % (25:20:55 v/v), apparent pH 3.3, as mobile phase, and UV detection at 254 nm. The peak area response versus concentration was linear in a concentration range from 5.0 to 50.0 μg/ml of BD and from 20.0 to 200.0 μgl ml of SA. The correlation coefficients were 0.9997 for BD and 0.9987 for SA, and the relative standard errors of estimates were 1.38% for BD and 3.27% for SA. The coefficient of variation and the recovery average were, respectively, 0.41-1.15% and 100.09% for BD, and 0.57-0.95% and 99.79% for SA.</description><subject>Administration, Topical</subject><subject>Analysis</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - analysis</subject><subject>Betamethasone - administration & dosage</subject><subject>Betamethasone - analogs & derivatives</subject><subject>Betamethasone - analysis</subject><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, High Pressure Liquid - standards</subject><subject>Chromatography, High Pressure Liquid - statistics & numerical data</subject><subject>General pharmacology</subject><subject>Glucocorticoids</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Ointments</subject><subject>Pharmacology. Drug treatments</subject><subject>Salicylic Acid - administration & dosage</subject><subject>Salicylic Acid - analysis</subject><subject>Solutions</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGK1TAUhoMo43X0AVwIWYi7apI2aYNuxjvqCBe8oK7LaXo6zdA2nSRF-gS-trlzrwMizCKcxf_9h5yPkJecvc050-9YrnLNCl0xzSqpZPmIbLgULJOlEo_J5pBnCZBPybMQbhjjQkt5Rs50VSolxIb8vsSIfrQTROsm6jr6ESOMGHsIbkJ6aWfv5hRBRApTS7_DYM2aHr0wtqV2ovse_AgGl2gNDHTvcQZ_ty7QZqVX9rrP9ug7l6jJIN3Z2yU1t713I0R37WHu1-fkSQdDwBeneU5-fv70Y3uV7b59-bq92GWmyFnMVFlo1TRKSamQtzkHXimBpuSaFxLbMsemhKYpUGPD1eFgFNAUTORGqI7n5-TNcW8663bBEOvRBoPDABO6JdRKc8FEUSSQH0HjXQgeu3r2dgS_1pzVB_n1f_JT59Vp-dKM2N43TrZT_vqUQ0iqOp982HCPCVEWJa8S9uGI2elO2i_nh7aOsA7O_-3kD_3i_T_1HmGIvQGP9Y1b_JT0PnDDH082s30</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Kedor-Hackmann, E. R. M.</creator><creator>Gianotto, E. A. S.</creator><creator>Santoro, M. I R. M</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980101</creationdate><title>Determination of Betamethasone Dipropionate and Salicylic Acid in Pharmaceutical Preparations by High-Performance Liquid Chromatography</title><author>Kedor-Hackmann, E. R. M. ; Gianotto, E. A. S. ; Santoro, M. I R. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-67496bb66556e1d31a1862ec719145ed73eb7abb4e9eb160012e2ab4023c26f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Topical</topic><topic>Analysis</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - analysis</topic><topic>Betamethasone - administration & dosage</topic><topic>Betamethasone - analogs & derivatives</topic><topic>Betamethasone - analysis</topic><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Chromatography, High Pressure Liquid - standards</topic><topic>Chromatography, High Pressure Liquid - statistics & numerical data</topic><topic>General pharmacology</topic><topic>Glucocorticoids</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Ointments</topic><topic>Pharmacology. Drug treatments</topic><topic>Salicylic Acid - administration & dosage</topic><topic>Salicylic Acid - analysis</topic><topic>Solutions</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kedor-Hackmann, E. R. M.</creatorcontrib><creatorcontrib>Gianotto, E. A. S.</creatorcontrib><creatorcontrib>Santoro, M. I R. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug development and industrial pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kedor-Hackmann, E. R. M.</au><au>Gianotto, E. A. S.</au><au>Santoro, M. I R. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of Betamethasone Dipropionate and Salicylic Acid in Pharmaceutical Preparations by High-Performance Liquid Chromatography</atitle><jtitle>Drug development and industrial pharmacy</jtitle><addtitle>Drug Dev Ind Pharm</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>24</volume><issue>6</issue><spage>553</spage><epage>555</epage><pages>553-555</pages><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>Abstract
The simultaneous determination of betamethasone dipropionate (BD) and salicylic acid (SA) in both ointment and topical solution was developed using high-performance liquid chromatography (HPLC). The method was standardized using a LiChrospher(r) 100 RP-18 (125 × 4 mm, 5 μm) column, acetonitrile-tetrahydro-furan-acetic acid 1 % (25:20:55 v/v), apparent pH 3.3, as mobile phase, and UV detection at 254 nm. The peak area response versus concentration was linear in a concentration range from 5.0 to 50.0 μg/ml of BD and from 20.0 to 200.0 μgl ml of SA. The correlation coefficients were 0.9997 for BD and 0.9987 for SA, and the relative standard errors of estimates were 1.38% for BD and 3.27% for SA. The coefficient of variation and the recovery average were, respectively, 0.41-1.15% and 100.09% for BD, and 0.57-0.95% and 99.79% for SA.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>9876622</pmid><doi>10.3109/03639049809085657</doi><tpages>3</tpages></addata></record> |
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| ispartof | Drug development and industrial pharmacy, 1998-01, Vol.24 (6), p.553-555 |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Administration, Topical Analysis Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - analysis Betamethasone - administration & dosage Betamethasone - analogs & derivatives Betamethasone - analysis Biological and medical sciences Chemistry, Pharmaceutical Chromatography, High Pressure Liquid - methods Chromatography, High Pressure Liquid - standards Chromatography, High Pressure Liquid - statistics & numerical data General pharmacology Glucocorticoids Humans Medical sciences Ointments Pharmacology. Drug treatments Salicylic Acid - administration & dosage Salicylic Acid - analysis Solutions Spectrophotometry, Ultraviolet |
| title | Determination of Betamethasone Dipropionate and Salicylic Acid in Pharmaceutical Preparations by High-Performance Liquid Chromatography |
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