The ocular hypotensive action of SK&F 86466 in the conscious rabbit

SK&F 86466, 6-chloro-3-methyl-2,3,4,5-tetra-hydro-1H-3-benzazeplne, a potent and selective competitive antagonist of the alpha2-adrenoceptor is of interest as a potential antlglaucoma agent. Following instillation into the rabbit eye, SK&F 86466 produced concentration (0.25 to 10%) dependent...

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Veröffentlicht in:	Current eye research 1984, Vol.3 (5), p.737-742
Hauptverfasser:	Matthews, William D., Sulpizio, Anthony, Fowler, Philip J., Demarinis, Robert, Hieble, J. Paul, Bergamini, Michael V.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - pharmacology Benzazepines - pharmacology Blood Pressure - drug effects Glaucoma, Open-Angle - drug therapy Intraocular Pressure - drug effects Male Rabbits
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