Tissue Engineering for Conjunctival Reconstruction: Established Methods and Future Outlooks
Reconstruction of the conjunctiva is an essential part of ocular surface regeneration, especially if an extensive area or the whole ocular surface is affected, such as in patients with ocular cicatricial pemphigoid, Stevens-Johnson syndrome, toxic epidermal necrolysis, or chemical/thermal burns. In...
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| Veröffentlicht in: | Current eye research 2009-11, Vol.34 (11), p.913-924 |
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| container_title | Current eye research |
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| creator | Schrader, Stefan Notara, Maria Beaconsfield, Michele Tuft, Stephen J. Daniels, Julie T. Geerling, Gerd |
| description | Reconstruction of the conjunctiva is an essential part of ocular surface regeneration, especially if an extensive area or the whole ocular surface is affected, such as in patients with ocular cicatricial pemphigoid, Stevens-Johnson syndrome, toxic epidermal necrolysis, or chemical/thermal burns. In these situations, corneal reconstruction almost inevitably fails unless the conjunctival surface is first repaired and a deep fornix is restored. The growing field of tissue engineering and advances in stem cell research offer promising new alternatives for these challenges. This article reviews the present approaches for reconstruction of the conjunctival surface, considering the established strategies and new potential methodologies. |
| doi_str_mv | 10.3109/02713680903198045 |
| format | Article |
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In these situations, corneal reconstruction almost inevitably fails unless the conjunctival surface is first repaired and a deep fornix is restored. The growing field of tissue engineering and advances in stem cell research offer promising new alternatives for these challenges. This article reviews the present approaches for reconstruction of the conjunctival surface, considering the established strategies and new potential methodologies.</description><identifier>ISSN: 0271-3683</identifier><identifier>EISSN: 1460-2202</identifier><identifier>DOI: 10.3109/02713680903198045</identifier><identifier>PMID: 19958107</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Cell therapy ; Conjunctiva ; Conjunctiva - cytology ; Conjunctiva - physiology ; Conjunctival Diseases - surgery ; Humans ; Limbus Corneae - cytology ; Mouth Mucosa - transplantation ; Nasal Mucosa - transplantation ; Ocular surface ; Ocular surface reconstruction ; Reconstructive Surgical Procedures - methods ; Regeneration - physiology ; Stem Cell Transplantation ; Stem Cells - cytology ; Tissue engineering ; Tissue Engineering - methods</subject><ispartof>Current eye research, 2009-11, Vol.34 (11), p.913-924</ispartof><rights>2009 Informa Healthcare USA, Inc. 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-10a82ec04a3a65a044ce1ba1e50bf28b6f93f2bc862dff8941c841078c51cd3a3</citedby><cites>FETCH-LOGICAL-c405t-10a82ec04a3a65a044ce1ba1e50bf28b6f93f2bc862dff8941c841078c51cd3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02713680903198045$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02713680903198045$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19958107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schrader, Stefan</creatorcontrib><creatorcontrib>Notara, Maria</creatorcontrib><creatorcontrib>Beaconsfield, Michele</creatorcontrib><creatorcontrib>Tuft, Stephen J.</creatorcontrib><creatorcontrib>Daniels, Julie T.</creatorcontrib><creatorcontrib>Geerling, Gerd</creatorcontrib><title>Tissue Engineering for Conjunctival Reconstruction: Established Methods and Future Outlooks</title><title>Current eye research</title><addtitle>Curr Eye Res</addtitle><description>Reconstruction of the conjunctiva is an essential part of ocular surface regeneration, especially if an extensive area or the whole ocular surface is affected, such as in patients with ocular cicatricial pemphigoid, Stevens-Johnson syndrome, toxic epidermal necrolysis, or chemical/thermal burns. In these situations, corneal reconstruction almost inevitably fails unless the conjunctival surface is first repaired and a deep fornix is restored. The growing field of tissue engineering and advances in stem cell research offer promising new alternatives for these challenges. This article reviews the present approaches for reconstruction of the conjunctival surface, considering the established strategies and new potential methodologies.</description><subject>Cell therapy</subject><subject>Conjunctiva</subject><subject>Conjunctiva - cytology</subject><subject>Conjunctiva - physiology</subject><subject>Conjunctival Diseases - surgery</subject><subject>Humans</subject><subject>Limbus Corneae - cytology</subject><subject>Mouth Mucosa - transplantation</subject><subject>Nasal Mucosa - transplantation</subject><subject>Ocular surface</subject><subject>Ocular surface reconstruction</subject><subject>Reconstructive Surgical Procedures - methods</subject><subject>Regeneration - physiology</subject><subject>Stem Cell Transplantation</subject><subject>Stem Cells - cytology</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - methods</subject><issn>0271-3683</issn><issn>1460-2202</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMobk4_gC-SL1C9adMuVV9kbCpMBjKffChpmqydXSL5o-zb27KBiOjT5d57zuHwQ-icwGVCIL-CeEySjEEOCckZ0PQADQnNIIpjiA_RsP9HnSAZoBPn1gD9gR6jAcnzlBEYD9HrsnEuSDzVq0ZLaRu9wspYPDF6HbTwzQdv8bMURjtvQ7cbfY2nzvOybVwtK_wkfW0qh7mu8Cz4YCVeBN8a8-ZO0ZHirZNn-zlCL7PpcvIQzRf3j5O7eSQopD4iwFksBVCe8CzlQKmQpOREplCqmJWZyhMVl4JlcaUUyykRjHblmUiJqBKejBDZ5QprnLNSFe-22XC7LQgUPajiF6jOc7HzvIdyI6tvx55MJ7jdCRrd8djwT2PbqvB82xqrLNeicX323_k3P-y15K2vBbeyWJtgdcfjn3ZfgqOKHQ</recordid><startdate>200911</startdate><enddate>200911</enddate><creator>Schrader, Stefan</creator><creator>Notara, Maria</creator><creator>Beaconsfield, Michele</creator><creator>Tuft, Stephen J.</creator><creator>Daniels, Julie T.</creator><creator>Geerling, Gerd</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200911</creationdate><title>Tissue Engineering for Conjunctival Reconstruction: Established Methods and Future Outlooks</title><author>Schrader, Stefan ; Notara, Maria ; Beaconsfield, Michele ; Tuft, Stephen J. ; Daniels, Julie T. ; Geerling, Gerd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-10a82ec04a3a65a044ce1ba1e50bf28b6f93f2bc862dff8941c841078c51cd3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Cell therapy</topic><topic>Conjunctiva</topic><topic>Conjunctiva - cytology</topic><topic>Conjunctiva - physiology</topic><topic>Conjunctival Diseases - surgery</topic><topic>Humans</topic><topic>Limbus Corneae - cytology</topic><topic>Mouth Mucosa - transplantation</topic><topic>Nasal Mucosa - transplantation</topic><topic>Ocular surface</topic><topic>Ocular surface reconstruction</topic><topic>Reconstructive Surgical Procedures - methods</topic><topic>Regeneration - physiology</topic><topic>Stem Cell Transplantation</topic><topic>Stem Cells - cytology</topic><topic>Tissue engineering</topic><topic>Tissue Engineering - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schrader, Stefan</creatorcontrib><creatorcontrib>Notara, Maria</creatorcontrib><creatorcontrib>Beaconsfield, Michele</creatorcontrib><creatorcontrib>Tuft, Stephen J.</creatorcontrib><creatorcontrib>Daniels, Julie T.</creatorcontrib><creatorcontrib>Geerling, Gerd</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Current eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schrader, Stefan</au><au>Notara, Maria</au><au>Beaconsfield, Michele</au><au>Tuft, Stephen J.</au><au>Daniels, Julie T.</au><au>Geerling, Gerd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue Engineering for Conjunctival Reconstruction: Established Methods and Future Outlooks</atitle><jtitle>Current eye research</jtitle><addtitle>Curr Eye Res</addtitle><date>2009-11</date><risdate>2009</risdate><volume>34</volume><issue>11</issue><spage>913</spage><epage>924</epage><pages>913-924</pages><issn>0271-3683</issn><eissn>1460-2202</eissn><abstract>Reconstruction of the conjunctiva is an essential part of ocular surface regeneration, especially if an extensive area or the whole ocular surface is affected, such as in patients with ocular cicatricial pemphigoid, Stevens-Johnson syndrome, toxic epidermal necrolysis, or chemical/thermal burns. In these situations, corneal reconstruction almost inevitably fails unless the conjunctival surface is first repaired and a deep fornix is restored. The growing field of tissue engineering and advances in stem cell research offer promising new alternatives for these challenges. This article reviews the present approaches for reconstruction of the conjunctival surface, considering the established strategies and new potential methodologies.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>19958107</pmid><doi>10.3109/02713680903198045</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-3683 |
| ispartof | Current eye research, 2009-11, Vol.34 (11), p.913-924 |
| issn | 0271-3683 1460-2202 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Cell therapy Conjunctiva Conjunctiva - cytology Conjunctiva - physiology Conjunctival Diseases - surgery Humans Limbus Corneae - cytology Mouth Mucosa - transplantation Nasal Mucosa - transplantation Ocular surface Ocular surface reconstruction Reconstructive Surgical Procedures - methods Regeneration - physiology Stem Cell Transplantation Stem Cells - cytology Tissue engineering Tissue Engineering - methods |
| title | Tissue Engineering for Conjunctival Reconstruction: Established Methods and Future Outlooks |
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