Microencapsulation of thyme oil by coacervation
The objective of this work is to develop a novel coacervation process to produce microcapsules of polylactide (PLA) to encapsulate thyme oil that will be used in cosmetics. The novelty of this approach consists of dissolving PLA in dimethylformamide (DMF) which is a good solvent for PLA but in addit...
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| Veröffentlicht in: | Journal of microencapsulation 2009-12, Vol.26 (8), p.667-675 |
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| container_end_page | 675 |
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| container_issue | 8 |
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| container_title | Journal of microencapsulation |
| container_volume | 26 |
| creator | Martins, Isabel M. Rodrigues, Sofia N. Barreiro, Filomena Rodrigues, Alírio. E. |
| description | The objective of this work is to develop a novel coacervation process to produce microcapsules of polylactide (PLA) to encapsulate thyme oil that will be used in cosmetics. The novelty of this approach consists of dissolving PLA in dimethylformamide (DMF) which is a good solvent for PLA but in addition has high solubility in water. Upon contact with water, the homogeneous solution of PLA in DMF promotes the precipitation of PLA around the thyme oil core. The produced microcapsules have bimodal particle size distributions in volume with a mean particle size of 40 µm. Microcapsules analysis by microscopy have confirmed the spherical shape, the rough surface and allowed the estimation of the wall thickness around 5 µm. Quantification of the encapsulated thyme oil was performed by gas chromatography and allowed to evaluate the quality of the encapsulated oil and pointed out for a preferential encapsulation of thyme oil apolar compounds. |
| doi_str_mv | 10.3109/02652040802646599 |
| format | Article |
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Quantification of the encapsulated thyme oil was performed by gas chromatography and allowed to evaluate the quality of the encapsulated oil and pointed out for a preferential encapsulation of thyme oil apolar compounds.</description><identifier>ISSN: 0265-2048</identifier><identifier>EISSN: 1464-5246</identifier><identifier>DOI: 10.3109/02652040802646599</identifier><identifier>PMID: 19888875</identifier><identifier>CODEN: JOMIEF</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Biological and medical sciences ; coacervation ; Cosmetics ; Drug Compounding - methods ; Drug Packaging - methods ; General pharmacology ; Medical sciences ; Microcapsules ; Oils, Volatile ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. 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E.</creatorcontrib><title>Microencapsulation of thyme oil by coacervation</title><title>Journal of microencapsulation</title><addtitle>J Microencapsul</addtitle><description>The objective of this work is to develop a novel coacervation process to produce microcapsules of polylactide (PLA) to encapsulate thyme oil that will be used in cosmetics. The novelty of this approach consists of dissolving PLA in dimethylformamide (DMF) which is a good solvent for PLA but in addition has high solubility in water. Upon contact with water, the homogeneous solution of PLA in DMF promotes the precipitation of PLA around the thyme oil core. The produced microcapsules have bimodal particle size distributions in volume with a mean particle size of 40 µm. Microcapsules analysis by microscopy have confirmed the spherical shape, the rough surface and allowed the estimation of the wall thickness around 5 µm. Quantification of the encapsulated thyme oil was performed by gas chromatography and allowed to evaluate the quality of the encapsulated oil and pointed out for a preferential encapsulation of thyme oil apolar compounds.</description><subject>Biological and medical sciences</subject><subject>coacervation</subject><subject>Cosmetics</subject><subject>Drug Compounding - methods</subject><subject>Drug Packaging - methods</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Microcapsules</subject><subject>Oils, Volatile</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>PLA</subject><subject>Polyesters</subject><subject>thyme oil</subject><subject>Thymus Plant - chemistry</subject><issn>0265-2048</issn><issn>1464-5246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6A7xIL-KpbpI2aYpeZPELVrzoOaT5YLukzZq0Sv-9WXdVRNi5zMA87zDvC8ApgpcZguUUYkowzCGLQ05JWe6BMcppnhKc030wXu_TCLAROAphCSEkJcOHYIRKFqsgYzB9qqV3upViFXorutq1iTNJtxganbjaJtWQSCek9u9fy2NwYIQN-mTbJ-D17vZl9pDOn-8fZzfzVOYZ6VIqKalKUxgmK6WwMVpTVgikK1xoU2GjlCqlYBVUpqCS4ApDpjEzFAuYQZJNwMXm7sq7t16Hjjd1kNpa0WrXB15kOYruMhpJtCGjjxC8Nnzl60b4gSPI1zHxfzFFzdn2el81Wv0qtrlE4HwLiCCFNV60sg4_HMaYEARR5K43XN0a5xvx4bxVvBODdf5blO364-qPfKGF7RZSeM2XrvdtTHiHi0-pK5Un</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Martins, Isabel M.</creator><creator>Rodrigues, Sofia N.</creator><creator>Barreiro, Filomena</creator><creator>Rodrigues, Alírio. 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E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-6c65b9f7f8cbdd2ffee687a1eb27efb2fddd9ca8b0df76c52b208e28f62a03053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>coacervation</topic><topic>Cosmetics</topic><topic>Drug Compounding - methods</topic><topic>Drug Packaging - methods</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Microcapsules</topic><topic>Oils, Volatile</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>PLA</topic><topic>Polyesters</topic><topic>thyme oil</topic><topic>Thymus Plant - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martins, Isabel M.</creatorcontrib><creatorcontrib>Rodrigues, Sofia N.</creatorcontrib><creatorcontrib>Barreiro, Filomena</creatorcontrib><creatorcontrib>Rodrigues, Alírio. E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of microencapsulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martins, Isabel M.</au><au>Rodrigues, Sofia N.</au><au>Barreiro, Filomena</au><au>Rodrigues, Alírio. 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| fulltext | fulltext |
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| ispartof | Journal of microencapsulation, 2009-12, Vol.26 (8), p.667-675 |
| issn | 0265-2048 1464-5246 |
| language | eng |
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| source | MEDLINE; Taylor & Francis; Taylor & Francis Medical Library - CRKN |
| subjects | Biological and medical sciences coacervation Cosmetics Drug Compounding - methods Drug Packaging - methods General pharmacology Medical sciences Microcapsules Oils, Volatile Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLA Polyesters thyme oil Thymus Plant - chemistry |
| title | Microencapsulation of thyme oil by coacervation |
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