Effect of Helicobacter pylori Eradication on Antral Gastrin- and Somatostatin-Immunoreactive Cell Density and Gastrin and Somatostatin Concentrations
The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of Helicobacter pylori. After H. pylori eradication...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1993, Vol.28 (10), p.858-864 |
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| container_title | Scandinavian journal of gastroenterology |
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| creator | Queiroz, D. M. M. Mendes, E. N. Rocha, G. A. Moura, S. B. Resende, L. M. H. Barbosa, A. J. A. Coelho, L. G. V. Passos, M. C. E. Castro, L. P. Oliveira, C. A. Lima, G. F. |
| description | The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of Helicobacter pylori. After H. pylori eradication both antral somatostatin concentration (p = 0.0002) and antral D-cell density (p = 0.01) increased significantly. Conversely, although the number of G-cells was unchanged, antral (p = 0.0002) and serum (p = 0.001) gastrin contents decreased significantly. The number of oxyntic D-cells did not change significantly. These results strongly suggest that the hypergastrinaemia observed in H. pylori-positive patients may be due to a deficiency in antral somatostatin, which normally inhibits the synthesis and release of gastrin. |
| doi_str_mv | 10.3109/00365529309103125 |
| format | Article |
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M. M. ; Mendes, E. N. ; Rocha, G. A. ; Moura, S. B. ; Resende, L. M. H. ; Barbosa, A. J. A. ; Coelho, L. G. V. ; Passos, M. C. E. ; Castro, L. P. ; Oliveira, C. A. ; Lima, G. F.</creator><creatorcontrib>Queiroz, D. M. M. ; Mendes, E. N. ; Rocha, G. A. ; Moura, S. B. ; Resende, L. M. H. ; Barbosa, A. J. A. ; Coelho, L. G. V. ; Passos, M. C. E. ; Castro, L. P. ; Oliveira, C. A. ; Lima, G. F.</creatorcontrib><description>The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of Helicobacter pylori. After H. pylori eradication both antral somatostatin concentration (p = 0.0002) and antral D-cell density (p = 0.01) increased significantly. Conversely, although the number of G-cells was unchanged, antral (p = 0.0002) and serum (p = 0.001) gastrin contents decreased significantly. The number of oxyntic D-cells did not change significantly. These results strongly suggest that the hypergastrinaemia observed in H. pylori-positive patients may be due to a deficiency in antral somatostatin, which normally inhibits the synthesis and release of gastrin.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.3109/00365529309103125</identifier><identifier>PMID: 7903471</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>Adult ; Antral D-cells ; antral G-cells ; antral gastrin ; antral somatostatin ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Biopsy ; Cell Count ; Chronic Disease ; Duodenal Ulcer - diagnosis ; Duodenal Ulcer - drug therapy ; Duodenal Ulcer - metabolism ; Duodenal Ulcer - microbiology ; Female ; Gastric Mucosa - metabolism ; Gastric Mucosa - pathology ; Gastrins - metabolism ; Gastritis - diagnosis ; Gastritis - drug therapy ; Gastritis - metabolism ; Gastritis - microbiology ; Gastroscopy ; Helicobacter Infections ; Helicobacter pylori ; Helicobacter pylori infection ; Human bacterial diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Pilot Projects ; Pyloric Antrum - metabolism ; Pyloric Antrum - pathology ; Somatostatin - metabolism ; Time Factors</subject><ispartof>Scandinavian journal of gastroenterology, 1993, Vol.28 (10), p.858-864</ispartof><rights>1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-5c147b2f4b8871e0abfc5c1648716a3e7764f795165c52fc698a88f829c0c0733</citedby><cites>FETCH-LOGICAL-c440t-5c147b2f4b8871e0abfc5c1648716a3e7764f795165c52fc698a88f829c0c0733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365529309103125$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365529309103125$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3799060$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7903471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Queiroz, D. M. M.</creatorcontrib><creatorcontrib>Mendes, E. N.</creatorcontrib><creatorcontrib>Rocha, G. A.</creatorcontrib><creatorcontrib>Moura, S. B.</creatorcontrib><creatorcontrib>Resende, L. M. H.</creatorcontrib><creatorcontrib>Barbosa, A. J. A.</creatorcontrib><creatorcontrib>Coelho, L. G. V.</creatorcontrib><creatorcontrib>Passos, M. C. E.</creatorcontrib><creatorcontrib>Castro, L. P.</creatorcontrib><creatorcontrib>Oliveira, C. A.</creatorcontrib><creatorcontrib>Lima, G. F.</creatorcontrib><title>Effect of Helicobacter pylori Eradication on Antral Gastrin- and Somatostatin-Immunoreactive Cell Density and Gastrin and Somatostatin Concentrations</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of Helicobacter pylori. After H. pylori eradication both antral somatostatin concentration (p = 0.0002) and antral D-cell density (p = 0.01) increased significantly. Conversely, although the number of G-cells was unchanged, antral (p = 0.0002) and serum (p = 0.001) gastrin contents decreased significantly. The number of oxyntic D-cells did not change significantly. These results strongly suggest that the hypergastrinaemia observed in H. pylori-positive patients may be due to a deficiency in antral somatostatin, which normally inhibits the synthesis and release of gastrin.</description><subject>Adult</subject><subject>Antral D-cells</subject><subject>antral G-cells</subject><subject>antral gastrin</subject><subject>antral somatostatin</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cell Count</subject><subject>Chronic Disease</subject><subject>Duodenal Ulcer - diagnosis</subject><subject>Duodenal Ulcer - drug therapy</subject><subject>Duodenal Ulcer - metabolism</subject><subject>Duodenal Ulcer - microbiology</subject><subject>Female</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastrins - metabolism</subject><subject>Gastritis - diagnosis</subject><subject>Gastritis - drug therapy</subject><subject>Gastritis - metabolism</subject><subject>Gastritis - microbiology</subject><subject>Gastroscopy</subject><subject>Helicobacter Infections</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori infection</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Pyloric Antrum - metabolism</subject><subject>Pyloric Antrum - pathology</subject><subject>Somatostatin - metabolism</subject><subject>Time Factors</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFq3DAQhkVpSDdpH6CHgg6lNzcjy7Ys2kvYbJNAoIekZzPWSkTBlraSnLIP0vet3HUDJRAQCOn__l-jGULeM_jMGcgzAN7UdSk5SAaclfUrsmI1lIUQ0L4mq1kvMsDekJMYHwCgFpU8JsdCAq8EW5HfG2O0StQbeqUHq3yPKulAd_vBB0s3AbdWYbLe0bzOXQo40EuMKVhXUHRbeutHTD6mDLniehwn54POIfZR07UeBnqhXbRp_xdenM-MdO2d0nP6_FR8S44MDlG_W_ZT8uPb5m59Vdx8v7xen98UqqogFbVilehLU_VtK5gG7I3Kd02VTw1yLURTGSFr1tSqLo1qZItta9pSKlAgOD8lnw65u-B_TjqmbrRR5aLRaT_FTjSslEw0GWQHUAUfY9Cm2wU7Yth3DLp5FN2zUWTPhyV86ke9fXIsvc_6x0XHqHAwAZ2y8QnjQkpoIGNfD5h1xocRf_kwbLuE84D-efhLVXz5z36vcUj3CoPuHvwUXG7vC3_4A9Znt9w</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Queiroz, D. M. M.</creator><creator>Mendes, E. N.</creator><creator>Rocha, G. A.</creator><creator>Moura, S. B.</creator><creator>Resende, L. M. H.</creator><creator>Barbosa, A. J. A.</creator><creator>Coelho, L. G. V.</creator><creator>Passos, M. C. E.</creator><creator>Castro, L. P.</creator><creator>Oliveira, C. A.</creator><creator>Lima, G. F.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Effect of Helicobacter pylori Eradication on Antral Gastrin- and Somatostatin-Immunoreactive Cell Density and Gastrin and Somatostatin Concentrations</title><author>Queiroz, D. M. M. ; Mendes, E. N. ; Rocha, G. A. ; Moura, S. B. ; Resende, L. M. H. ; Barbosa, A. J. A. ; Coelho, L. G. 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M.</au><au>Mendes, E. N.</au><au>Rocha, G. A.</au><au>Moura, S. B.</au><au>Resende, L. M. H.</au><au>Barbosa, A. J. A.</au><au>Coelho, L. G. V.</au><au>Passos, M. C. E.</au><au>Castro, L. P.</au><au>Oliveira, C. A.</au><au>Lima, G. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Helicobacter pylori Eradication on Antral Gastrin- and Somatostatin-Immunoreactive Cell Density and Gastrin and Somatostatin Concentrations</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1993</date><risdate>1993</risdate><volume>28</volume><issue>10</issue><spage>858</spage><epage>864</epage><pages>858-864</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of Helicobacter pylori. After H. pylori eradication both antral somatostatin concentration (p = 0.0002) and antral D-cell density (p = 0.01) increased significantly. Conversely, although the number of G-cells was unchanged, antral (p = 0.0002) and serum (p = 0.001) gastrin contents decreased significantly. The number of oxyntic D-cells did not change significantly. These results strongly suggest that the hypergastrinaemia observed in H. pylori-positive patients may be due to a deficiency in antral somatostatin, which normally inhibits the synthesis and release of gastrin.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>7903471</pmid><doi>10.3109/00365529309103125</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Scandinavian journal of gastroenterology, 1993, Vol.28 (10), p.858-864 |
| issn | 0036-5521 1502-7708 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Antral D-cells antral G-cells antral gastrin antral somatostatin Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Biopsy Cell Count Chronic Disease Duodenal Ulcer - diagnosis Duodenal Ulcer - drug therapy Duodenal Ulcer - metabolism Duodenal Ulcer - microbiology Female Gastric Mucosa - metabolism Gastric Mucosa - pathology Gastrins - metabolism Gastritis - diagnosis Gastritis - drug therapy Gastritis - metabolism Gastritis - microbiology Gastroscopy Helicobacter Infections Helicobacter pylori Helicobacter pylori infection Human bacterial diseases Humans Infectious diseases Male Medical sciences Middle Aged Pilot Projects Pyloric Antrum - metabolism Pyloric Antrum - pathology Somatostatin - metabolism Time Factors |
| title | Effect of Helicobacter pylori Eradication on Antral Gastrin- and Somatostatin-Immunoreactive Cell Density and Gastrin and Somatostatin Concentrations |
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