The Effects of Ammonia Tolerance Tests on the Cerebrospinal Fluid Concentrations of Amino Acids and Indoleamines in Patients with Liver Cirrhosis
To study the effect of ammonia administration on amino acids and indoleamines in cerebrospinal fluid (CSF) and on amino acids, insulin, and glucagon in plasma in humans with liver cirrhosis, we performed seven ammonia tolerance tests on six patients with stable liver cirrhosis. The grade of encephal...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1990, Vol.25 (5), p.422-428 |
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| creator | Jonung, T. Jeppsson, B. Herlin, P. Nobin, A. Hultberg, B. |
| description | To study the effect of ammonia administration on amino acids and indoleamines in cerebrospinal fluid (CSF) and on amino acids, insulin, and glucagon in plasma in humans with liver cirrhosis, we performed seven ammonia tolerance tests on six patients with stable liver cirrhosis. The grade of encephalopathy was determined by psychometric tests. Only one of the patients had pronounced encephalopathy. The other patients had no or only slight encephalopathy. The plasma concentrations of valine, leucine, isoleucine, phenylalanine, tyrosine, and methionine decreased after the ammonia load, whereas no changes were found in the plasma concentrations of glucagon and insulin. In CSF the concentrations of glutamine, aromatic amino acids, and indoleamines increased only in the patient who had pronounced encephalopathy, whereas no changes were found in the other patients. The effect of an ammonia load on the concentrations of neutral amino acids in CSF in patients with pronounced encephalopathy remains to be demonstrated. |
| doi_str_mv | 10.3109/00365529009095510 |
| format | Article |
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The grade of encephalopathy was determined by psychometric tests. Only one of the patients had pronounced encephalopathy. The other patients had no or only slight encephalopathy. The plasma concentrations of valine, leucine, isoleucine, phenylalanine, tyrosine, and methionine decreased after the ammonia load, whereas no changes were found in the plasma concentrations of glucagon and insulin. In CSF the concentrations of glutamine, aromatic amino acids, and indoleamines increased only in the patient who had pronounced encephalopathy, whereas no changes were found in the other patients. The effect of an ammonia load on the concentrations of neutral amino acids in CSF in patients with pronounced encephalopathy remains to be demonstrated.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.3109/00365529009095510</identifier><identifier>PMID: 1694297</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>5-Hydroxytryptophan - cerebrospinal fluid ; Adult ; Aged ; Amino Acids - blood ; Amino Acids - cerebrospinal fluid ; Ammonia ; Ammonium Chloride - administration & dosage ; Ammonium Chloride - pharmacology ; Biological and medical sciences ; Drug Tolerance ; Gastroenterology. Liver. Pancreas. Abdomen ; Glucagons ; Humans ; Hydroxyindoleacetic Acid - cerebrospinal fluid ; Indoleamines ; Insulin ; liver cirrhosis ; Liver Cirrhosis - cerebrospinal fluid ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; neutral amino acids ; Other diseases. Semiology ; Serotonin - cerebrospinal fluid</subject><ispartof>Scandinavian journal of gastroenterology, 1990, Vol.25 (5), p.422-428</ispartof><rights>1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-7529b2f52e7c687b232be79fab026cbd18d2720d623ee42396bd1f69130bee193</citedby><cites>FETCH-LOGICAL-c431t-7529b2f52e7c687b232be79fab026cbd18d2720d623ee42396bd1f69130bee193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365529009095510$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365529009095510$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19451497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1694297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jonung, T.</creatorcontrib><creatorcontrib>Jeppsson, B.</creatorcontrib><creatorcontrib>Herlin, P.</creatorcontrib><creatorcontrib>Nobin, A.</creatorcontrib><creatorcontrib>Hultberg, B.</creatorcontrib><title>The Effects of Ammonia Tolerance Tests on the Cerebrospinal Fluid Concentrations of Amino Acids and Indoleamines in Patients with Liver Cirrhosis</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>To study the effect of ammonia administration on amino acids and indoleamines in cerebrospinal fluid (CSF) and on amino acids, insulin, and glucagon in plasma in humans with liver cirrhosis, we performed seven ammonia tolerance tests on six patients with stable liver cirrhosis. The grade of encephalopathy was determined by psychometric tests. Only one of the patients had pronounced encephalopathy. The other patients had no or only slight encephalopathy. The plasma concentrations of valine, leucine, isoleucine, phenylalanine, tyrosine, and methionine decreased after the ammonia load, whereas no changes were found in the plasma concentrations of glucagon and insulin. In CSF the concentrations of glutamine, aromatic amino acids, and indoleamines increased only in the patient who had pronounced encephalopathy, whereas no changes were found in the other patients. The effect of an ammonia load on the concentrations of neutral amino acids in CSF in patients with pronounced encephalopathy remains to be demonstrated.</description><subject>5-Hydroxytryptophan - cerebrospinal fluid</subject><subject>Adult</subject><subject>Aged</subject><subject>Amino Acids - blood</subject><subject>Amino Acids - cerebrospinal fluid</subject><subject>Ammonia</subject><subject>Ammonium Chloride - administration & dosage</subject><subject>Ammonium Chloride - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Drug Tolerance</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Glucagons</subject><subject>Humans</subject><subject>Hydroxyindoleacetic Acid - cerebrospinal fluid</subject><subject>Indoleamines</subject><subject>Insulin</subject><subject>liver cirrhosis</subject><subject>Liver Cirrhosis - cerebrospinal fluid</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>neutral amino acids</subject><subject>Other diseases. Semiology</subject><subject>Serotonin - cerebrospinal fluid</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMoYzv6AC6EbHRXmp-qSgXdNMWMDjTool0XqeSGypBK2qTKYR7DNzZttwwizCpwz3cOOfci9JqS95wS-YEQ3jYNk4RIIpuGkidoQxvCKiFI9xRtjnpVAPocvcj5lhDSiFpeoAvayppJsUG_9hPgK2tBLxlHi7fzHINTeB89JBU04D3koxTwUsgeEowp5oMLyuNrvzqD-1iwsCS1uBjOIS5EvNXOZKyCwTfBlDhVppCxC_hbQYsj4zu3THjnfkLCvUtpitnll-iZVT7Dq_N7ib5fX-37L9Xu6-ebfrurdM3pUolSe2S2YSB024mRcTaCkFaNhLV6NLQzTDBiWsYBasZlW2a2lZSTEYBKfonenXIPKf5YS8lhdlmD9ypAXPMgZFeLpmMFpCdQl-I5gR0Oyc0q3Q-UDMczDP-doXjenMPXcQbz4Djtvehvz7rKWnl7XLXLD5isG1r_4T6dOBdsTLO6i8mbYVH3Pqa_Jv7YNz7-Y59A-WXSKsFwG9dUbpgfKfEbsZG1_g</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Jonung, T.</creator><creator>Jeppsson, B.</creator><creator>Herlin, P.</creator><creator>Nobin, A.</creator><creator>Hultberg, B.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>The Effects of Ammonia Tolerance Tests on the Cerebrospinal Fluid Concentrations of Amino Acids and Indoleamines in Patients with Liver Cirrhosis</title><author>Jonung, T. ; Jeppsson, B. ; Herlin, P. ; Nobin, A. ; Hultberg, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-7529b2f52e7c687b232be79fab026cbd18d2720d623ee42396bd1f69130bee193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>5-Hydroxytryptophan - cerebrospinal fluid</topic><topic>Adult</topic><topic>Aged</topic><topic>Amino Acids - blood</topic><topic>Amino Acids - cerebrospinal fluid</topic><topic>Ammonia</topic><topic>Ammonium Chloride - administration & dosage</topic><topic>Ammonium Chloride - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Drug Tolerance</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Glucagons</topic><topic>Humans</topic><topic>Hydroxyindoleacetic Acid - cerebrospinal fluid</topic><topic>Indoleamines</topic><topic>Insulin</topic><topic>liver cirrhosis</topic><topic>Liver Cirrhosis - cerebrospinal fluid</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>neutral amino acids</topic><topic>Other diseases. Semiology</topic><topic>Serotonin - cerebrospinal fluid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jonung, T.</creatorcontrib><creatorcontrib>Jeppsson, B.</creatorcontrib><creatorcontrib>Herlin, P.</creatorcontrib><creatorcontrib>Nobin, A.</creatorcontrib><creatorcontrib>Hultberg, B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jonung, T.</au><au>Jeppsson, B.</au><au>Herlin, P.</au><au>Nobin, A.</au><au>Hultberg, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Ammonia Tolerance Tests on the Cerebrospinal Fluid Concentrations of Amino Acids and Indoleamines in Patients with Liver Cirrhosis</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1990</date><risdate>1990</risdate><volume>25</volume><issue>5</issue><spage>422</spage><epage>428</epage><pages>422-428</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>To study the effect of ammonia administration on amino acids and indoleamines in cerebrospinal fluid (CSF) and on amino acids, insulin, and glucagon in plasma in humans with liver cirrhosis, we performed seven ammonia tolerance tests on six patients with stable liver cirrhosis. The grade of encephalopathy was determined by psychometric tests. Only one of the patients had pronounced encephalopathy. The other patients had no or only slight encephalopathy. The plasma concentrations of valine, leucine, isoleucine, phenylalanine, tyrosine, and methionine decreased after the ammonia load, whereas no changes were found in the plasma concentrations of glucagon and insulin. In CSF the concentrations of glutamine, aromatic amino acids, and indoleamines increased only in the patient who had pronounced encephalopathy, whereas no changes were found in the other patients. The effect of an ammonia load on the concentrations of neutral amino acids in CSF in patients with pronounced encephalopathy remains to be demonstrated.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>1694297</pmid><doi>10.3109/00365529009095510</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Scandinavian journal of gastroenterology, 1990, Vol.25 (5), p.422-428 |
| issn | 0036-5521 1502-7708 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis |
| subjects | 5-Hydroxytryptophan - cerebrospinal fluid Adult Aged Amino Acids - blood Amino Acids - cerebrospinal fluid Ammonia Ammonium Chloride - administration & dosage Ammonium Chloride - pharmacology Biological and medical sciences Drug Tolerance Gastroenterology. Liver. Pancreas. Abdomen Glucagons Humans Hydroxyindoleacetic Acid - cerebrospinal fluid Indoleamines Insulin liver cirrhosis Liver Cirrhosis - cerebrospinal fluid Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged neutral amino acids Other diseases. Semiology Serotonin - cerebrospinal fluid |
| title | The Effects of Ammonia Tolerance Tests on the Cerebrospinal Fluid Concentrations of Amino Acids and Indoleamines in Patients with Liver Cirrhosis |
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