Blood reticulocyte count and plasma lactate dehydrogenase activity are positively related to the free fatty acid/albumin ratio in geriatric patients
The objective of this study was to investigate the in vivo relationship between plasma free fatty acid (FFA)/albumin molar ratio and indicators of cellular damage. A case series study was carried out in 20 geriatric patients in a stable clinical condition. Their plasma albumin concentration was in t...
Gespeichert in:
| Veröffentlicht in: | Scandinavian journal of clinical and laboratory investigation 1995, Vol.55 (7), p.649-653 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 653 |
|---|---|
| container_issue | 7 |
| container_start_page | 649 |
| container_title | Scandinavian journal of clinical and laboratory investigation |
| container_volume | 55 |
| creator | H∅stmark, A. T. Stensr∅d, B. Jebens, E. Lystad, E. Kierulf, P. Laake, K. |
| description | The objective of this study was to investigate the in vivo relationship between plasma free fatty acid (FFA)/albumin molar ratio and indicators of cellular damage. A case series study was carried out in 20 geriatric patients in a stable clinical condition. Their plasma albumin concentration was in the range 26-42 gl-1. There was a significant positive correlation between the FFA/albumin ratio and (a) reticulocyte count (r = 0.61, p = 0.006), (b) lactate dehydrogenase activity (r = 0.69, p = 0.002), and (c) haptoglobin concentration (r = 0.46, p = 0.05). The haemoglobin concentration was inversely related to relative reticulocyte count (r = -0.55, p = 0.01). Absolute and relative reticulocyte counts were positively associated (r = 0.92, p>0.0001). The results are in accordance with the contention that a high FFA/albumin ratio in vivo may elicit cellular damage. Further studies are required to elucidate to what extent a high FFA/albumin ratio might be causally related to diseases. |
| doi_str_mv | 10.3109/00365519509110265 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_informahealthcare_journals_10_3109_00365519509110265</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77832350</sourcerecordid><originalsourceid>FETCH-LOGICAL-c430t-e904403eeb213f99a6afb9676007c886cb23131af18fda5c103854db3aedf9a63</originalsourceid><addsrcrecordid>eNp9kcuKFTEQhoMo45nRB3AhZCHu2kk6fQu60WG8wIAbXTfVSWVOhnTSJmml38MHNodzHBBhNkmq_u8vKlWEvODsjeBMXjImurblsmWSc1Z37SOy4y2rq74busdkd9CrAoin5DylO1ZiMTRn5GzohOCS7cjvDy4ETSNmq1YX1JaRqrD6TMFrujhIM1AHKkMRNO43HcMtekhIS9L-tHmjEJEuIdkSottKLVdgTXOgeY_URCwH5AOorL4EN62z9TRCtoGWxy1GCzlaRZeSQp_TM_LEgEv4_HRfkO8fr79dfa5uvn76cvX-plKNYLlCyZqGCcSp5sJICR2YSXZ9x1ivhqFTUy244GD4YDS0ijMxtI2eBKA2hRYX5PWx7hLDjxVTHmebFDoHHsOaxr4fRC1aVkB-BFUMKUU04xLtDHEbORsPmxj_20TxvDwVX6cZ9b3jNPqivzrpkBQ4E8Erm-6xWjZ1X8uCvTti1psQZ_gVotNjhs2F-NcjHuri7T_2PYLLe1VWNt6FNfoy3gf-8Adf67j6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77832350</pqid></control><display><type>article</type><title>Blood reticulocyte count and plasma lactate dehydrogenase activity are positively related to the free fatty acid/albumin ratio in geriatric patients</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Taylor & Francis Journals Complete</source><creator>H∅stmark, A. T. ; Stensr∅d, B. ; Jebens, E. ; Lystad, E. ; Kierulf, P. ; Laake, K.</creator><creatorcontrib>H∅stmark, A. T. ; Stensr∅d, B. ; Jebens, E. ; Lystad, E. ; Kierulf, P. ; Laake, K.</creatorcontrib><description>The objective of this study was to investigate the in vivo relationship between plasma free fatty acid (FFA)/albumin molar ratio and indicators of cellular damage. A case series study was carried out in 20 geriatric patients in a stable clinical condition. Their plasma albumin concentration was in the range 26-42 gl-1. There was a significant positive correlation between the FFA/albumin ratio and (a) reticulocyte count (r = 0.61, p = 0.006), (b) lactate dehydrogenase activity (r = 0.69, p = 0.002), and (c) haptoglobin concentration (r = 0.46, p = 0.05). The haemoglobin concentration was inversely related to relative reticulocyte count (r = -0.55, p = 0.01). Absolute and relative reticulocyte counts were positively associated (r = 0.92, p>0.0001). The results are in accordance with the contention that a high FFA/albumin ratio in vivo may elicit cellular damage. Further studies are required to elucidate to what extent a high FFA/albumin ratio might be causally related to diseases.</description><identifier>ISSN: 0036-5513</identifier><identifier>EISSN: 1502-7686</identifier><identifier>DOI: 10.3109/00365519509110265</identifier><identifier>PMID: 8633190</identifier><identifier>CODEN: SJCLAY</identifier><language>eng</language><publisher>Oslo: Informa UK Ltd</publisher><subject>Aged ; Aged, 80 and over - physiology ; Ageing, cell death ; albumin ; Biological and medical sciences ; Cell physiology ; Cells - pathology ; fatty acids ; Fatty Acids, Nonesterified - blood ; Female ; Fundamental and applied biological sciences. Psychology ; geriatric patients ; Hemoglobins - analysis ; Humans ; L-Lactate Dehydrogenase - blood ; lactate dehydrogenase ; Male ; Molecular and cellular biology ; Regression Analysis ; Reticulocyte Count ; Serum Albumin - metabolism</subject><ispartof>Scandinavian journal of clinical and laboratory investigation, 1995, Vol.55 (7), p.649-653</ispartof><rights>1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-e904403eeb213f99a6afb9676007c886cb23131af18fda5c103854db3aedf9a63</citedby><cites>FETCH-LOGICAL-c430t-e904403eeb213f99a6afb9676007c886cb23131af18fda5c103854db3aedf9a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365519509110265$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365519509110265$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2942729$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8633190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>H∅stmark, A. T.</creatorcontrib><creatorcontrib>Stensr∅d, B.</creatorcontrib><creatorcontrib>Jebens, E.</creatorcontrib><creatorcontrib>Lystad, E.</creatorcontrib><creatorcontrib>Kierulf, P.</creatorcontrib><creatorcontrib>Laake, K.</creatorcontrib><title>Blood reticulocyte count and plasma lactate dehydrogenase activity are positively related to the free fatty acid/albumin ratio in geriatric patients</title><title>Scandinavian journal of clinical and laboratory investigation</title><addtitle>Scand J Clin Lab Invest</addtitle><description>The objective of this study was to investigate the in vivo relationship between plasma free fatty acid (FFA)/albumin molar ratio and indicators of cellular damage. A case series study was carried out in 20 geriatric patients in a stable clinical condition. Their plasma albumin concentration was in the range 26-42 gl-1. There was a significant positive correlation between the FFA/albumin ratio and (a) reticulocyte count (r = 0.61, p = 0.006), (b) lactate dehydrogenase activity (r = 0.69, p = 0.002), and (c) haptoglobin concentration (r = 0.46, p = 0.05). The haemoglobin concentration was inversely related to relative reticulocyte count (r = -0.55, p = 0.01). Absolute and relative reticulocyte counts were positively associated (r = 0.92, p>0.0001). The results are in accordance with the contention that a high FFA/albumin ratio in vivo may elicit cellular damage. Further studies are required to elucidate to what extent a high FFA/albumin ratio might be causally related to diseases.</description><subject>Aged</subject><subject>Aged, 80 and over - physiology</subject><subject>Ageing, cell death</subject><subject>albumin</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Cells - pathology</subject><subject>fatty acids</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>geriatric patients</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>lactate dehydrogenase</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Regression Analysis</subject><subject>Reticulocyte Count</subject><subject>Serum Albumin - metabolism</subject><issn>0036-5513</issn><issn>1502-7686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuKFTEQhoMo45nRB3AhZCHu2kk6fQu60WG8wIAbXTfVSWVOhnTSJmml38MHNodzHBBhNkmq_u8vKlWEvODsjeBMXjImurblsmWSc1Z37SOy4y2rq74busdkd9CrAoin5DylO1ZiMTRn5GzohOCS7cjvDy4ETSNmq1YX1JaRqrD6TMFrujhIM1AHKkMRNO43HcMtekhIS9L-tHmjEJEuIdkSottKLVdgTXOgeY_URCwH5AOorL4EN62z9TRCtoGWxy1GCzlaRZeSQp_TM_LEgEv4_HRfkO8fr79dfa5uvn76cvX-plKNYLlCyZqGCcSp5sJICR2YSXZ9x1ivhqFTUy244GD4YDS0ijMxtI2eBKA2hRYX5PWx7hLDjxVTHmebFDoHHsOaxr4fRC1aVkB-BFUMKUU04xLtDHEbORsPmxj_20TxvDwVX6cZ9b3jNPqivzrpkBQ4E8Erm-6xWjZ1X8uCvTti1psQZ_gVotNjhs2F-NcjHuri7T_2PYLLe1VWNt6FNfoy3gf-8Adf67j6</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>H∅stmark, A. T.</creator><creator>Stensr∅d, B.</creator><creator>Jebens, E.</creator><creator>Lystad, E.</creator><creator>Kierulf, P.</creator><creator>Laake, K.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Blood reticulocyte count and plasma lactate dehydrogenase activity are positively related to the free fatty acid/albumin ratio in geriatric patients</title><author>H∅stmark, A. T. ; Stensr∅d, B. ; Jebens, E. ; Lystad, E. ; Kierulf, P. ; Laake, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-e904403eeb213f99a6afb9676007c886cb23131af18fda5c103854db3aedf9a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aged</topic><topic>Aged, 80 and over - physiology</topic><topic>Ageing, cell death</topic><topic>albumin</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Cells - pathology</topic><topic>fatty acids</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>geriatric patients</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>lactate dehydrogenase</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Regression Analysis</topic><topic>Reticulocyte Count</topic><topic>Serum Albumin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>H∅stmark, A. T.</creatorcontrib><creatorcontrib>Stensr∅d, B.</creatorcontrib><creatorcontrib>Jebens, E.</creatorcontrib><creatorcontrib>Lystad, E.</creatorcontrib><creatorcontrib>Kierulf, P.</creatorcontrib><creatorcontrib>Laake, K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>H∅stmark, A. T.</au><au>Stensr∅d, B.</au><au>Jebens, E.</au><au>Lystad, E.</au><au>Kierulf, P.</au><au>Laake, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood reticulocyte count and plasma lactate dehydrogenase activity are positively related to the free fatty acid/albumin ratio in geriatric patients</atitle><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle><addtitle>Scand J Clin Lab Invest</addtitle><date>1995</date><risdate>1995</risdate><volume>55</volume><issue>7</issue><spage>649</spage><epage>653</epage><pages>649-653</pages><issn>0036-5513</issn><eissn>1502-7686</eissn><coden>SJCLAY</coden><abstract>The objective of this study was to investigate the in vivo relationship between plasma free fatty acid (FFA)/albumin molar ratio and indicators of cellular damage. A case series study was carried out in 20 geriatric patients in a stable clinical condition. Their plasma albumin concentration was in the range 26-42 gl-1. There was a significant positive correlation between the FFA/albumin ratio and (a) reticulocyte count (r = 0.61, p = 0.006), (b) lactate dehydrogenase activity (r = 0.69, p = 0.002), and (c) haptoglobin concentration (r = 0.46, p = 0.05). The haemoglobin concentration was inversely related to relative reticulocyte count (r = -0.55, p = 0.01). Absolute and relative reticulocyte counts were positively associated (r = 0.92, p>0.0001). The results are in accordance with the contention that a high FFA/albumin ratio in vivo may elicit cellular damage. Further studies are required to elucidate to what extent a high FFA/albumin ratio might be causally related to diseases.</abstract><cop>Oslo</cop><pub>Informa UK Ltd</pub><pmid>8633190</pmid><doi>10.3109/00365519509110265</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-5513 |
| ispartof | Scandinavian journal of clinical and laboratory investigation, 1995, Vol.55 (7), p.649-653 |
| issn | 0036-5513 1502-7686 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_00365519509110265 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Aged Aged, 80 and over - physiology Ageing, cell death albumin Biological and medical sciences Cell physiology Cells - pathology fatty acids Fatty Acids, Nonesterified - blood Female Fundamental and applied biological sciences. Psychology geriatric patients Hemoglobins - analysis Humans L-Lactate Dehydrogenase - blood lactate dehydrogenase Male Molecular and cellular biology Regression Analysis Reticulocyte Count Serum Albumin - metabolism |
| title | Blood reticulocyte count and plasma lactate dehydrogenase activity are positively related to the free fatty acid/albumin ratio in geriatric patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T16%3A11%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Blood%20reticulocyte%20count%20and%20plasma%20lactate%20dehydrogenase%20activity%20are%20positively%20related%20to%20the%20free%20fatty%20acid/albumin%20ratio%20in%20geriatric%20patients&rft.jtitle=Scandinavian%20journal%20of%20clinical%20and%20laboratory%20investigation&rft.au=H%E2%88%85stmark,%20A.%20T.&rft.date=1995&rft.volume=55&rft.issue=7&rft.spage=649&rft.epage=653&rft.pages=649-653&rft.issn=0036-5513&rft.eissn=1502-7686&rft.coden=SJCLAY&rft_id=info:doi/10.3109/00365519509110265&rft_dat=%3Cproquest_infor%3E77832350%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77832350&rft_id=info:pmid/8633190&rfr_iscdi=true |