Effect of Triiodothryonine on the Muscarinic Receptors and Acetylcholinesterase Activity of Developing Rat Brain
The effect of triiodothyronine was investigated on the developing muscarinic system in rat cerebral cortex. Triiodothyronine was administered from birth to day 30. In the synaptosomal membrane fraction of the cerebral cortex, acethylcholinesterase activity and the binding of the muscarinic ligand 3H...
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| Veröffentlicht in: | International journal of neuroscience 1989, Vol.44 (1-2), p.83-89 |
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| container_end_page | 89 |
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| container_issue | 1-2 |
| container_start_page | 83 |
| container_title | International journal of neuroscience |
| container_volume | 44 |
| creator | Moskovkin, G. N. Kálmán, M. Kardos, Julia Yarigin, K. N. Hajós, F. |
| description | The effect of triiodothyronine was investigated on the developing muscarinic system in rat cerebral cortex. Triiodothyronine was administered from birth to day 30. In the synaptosomal membrane fraction of the cerebral cortex, acethylcholinesterase activity and the binding of the muscarinic ligand 3H-quinuclydinylbenzylate increased significantly as compared to the control. An analysis of the binding curve based on Hill plots suggested a positive cooperativity of receptors of the membrane samples obtained from both hormone treated and control animals. The results obtained are in accordance with morphological, biochemical and clinical data on the thyroid hormone effect on central nervous system maturation. |
| doi_str_mv | 10.3109/00207458908986186 |
| format | Article |
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The results obtained are in accordance with morphological, biochemical and clinical data on the thyroid hormone effect on central nervous system maturation.</description><identifier>ISSN: 0020-7454</identifier><identifier>EISSN: 1563-5279</identifier><identifier>EISSN: 1543-5245</identifier><identifier>DOI: 10.3109/00207458908986186</identifier><identifier>CODEN: IJNUB7</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>acetylcholinesterase ; Biological and medical sciences ; developing brain ; Development. Metamorphosis. Moult. Ageing ; Fundamental and applied biological sciences. 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The results obtained are in accordance with morphological, biochemical and clinical data on the thyroid hormone effect on central nervous system maturation.</description><subject>acetylcholinesterase</subject><subject>Biological and medical sciences</subject><subject>developing brain</subject><subject>Development. Metamorphosis. Moult. Ageing</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>muscarinic receptors</subject><subject>triiodothyronine</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0020-7454</issn><issn>1563-5279</issn><issn>1543-5245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNp9kFtrFjEQhoNY8KP2B3iXm16u5rTZBL2ptR6gIpT2eplmJ25kmyxJ2rL_3nx8FRGhV8PMvM8cXkLecPZWcmbfMSbYoHpjmbFGc6NfkB3vtex6MdiXZLfvd02gXpGTUsJty6W1wpgdWS-8R1dp8vQ6h5CmVOe8pRgi0hRpnZF-vy8OcojB0St0uNaUC4U40TOHdVvcnJamLhUzFGzFGh5C3fYTP-EDLmkN8Se9gko_ZgjxNTnysBQ8eYrH5ObzxfX51-7yx5dv52eXnZODqZ02utdGeq2UEOhUz6Z2v8IWYXKC-wnkBAMTqMBLrrVlXDnXOwa3SguQx4Qf5rqcSsnoxzWHO8jbyNm4d238z7XGnB6YFdrLi88QXSh_QSuFHeTQdB8OuhB9ynfwmPIyjRW2JeU_kHxuzft_8BlhqXPzGMdf6T7HZsszR_4GRKGTag</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Moskovkin, G. N.</creator><creator>Kálmán, M.</creator><creator>Kardos, Julia</creator><creator>Yarigin, K. N.</creator><creator>Hajós, F.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1989</creationdate><title>Effect of Triiodothryonine on the Muscarinic Receptors and Acetylcholinesterase Activity of Developing Rat Brain</title><author>Moskovkin, G. N. ; Kálmán, M. ; Kardos, Julia ; Yarigin, K. N. ; Hajós, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-6865683f64422ec450d4544e50dadc21fda3da702e4af31669014cc5c0ab462a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>acetylcholinesterase</topic><topic>Biological and medical sciences</topic><topic>developing brain</topic><topic>Development. Metamorphosis. Moult. Ageing</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>muscarinic receptors</topic><topic>triiodothyronine</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moskovkin, G. N.</creatorcontrib><creatorcontrib>Kálmán, M.</creatorcontrib><creatorcontrib>Kardos, Julia</creatorcontrib><creatorcontrib>Yarigin, K. N.</creatorcontrib><creatorcontrib>Hajós, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>International journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moskovkin, G. N.</au><au>Kálmán, M.</au><au>Kardos, Julia</au><au>Yarigin, K. N.</au><au>Hajós, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Triiodothryonine on the Muscarinic Receptors and Acetylcholinesterase Activity of Developing Rat Brain</atitle><jtitle>International journal of neuroscience</jtitle><date>1989</date><risdate>1989</risdate><volume>44</volume><issue>1-2</issue><spage>83</spage><epage>89</epage><pages>83-89</pages><issn>0020-7454</issn><eissn>1563-5279</eissn><eissn>1543-5245</eissn><coden>IJNUB7</coden><abstract>The effect of triiodothyronine was investigated on the developing muscarinic system in rat cerebral cortex. Triiodothyronine was administered from birth to day 30. In the synaptosomal membrane fraction of the cerebral cortex, acethylcholinesterase activity and the binding of the muscarinic ligand 3H-quinuclydinylbenzylate increased significantly as compared to the control. An analysis of the binding curve based on Hill plots suggested a positive cooperativity of receptors of the membrane samples obtained from both hormone treated and control animals. The results obtained are in accordance with morphological, biochemical and clinical data on the thyroid hormone effect on central nervous system maturation.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><doi>10.3109/00207458908986186</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0020-7454 |
| ispartof | International journal of neuroscience, 1989, Vol.44 (1-2), p.83-89 |
| issn | 0020-7454 1563-5279 1543-5245 |
| language | eng |
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| source | Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | acetylcholinesterase Biological and medical sciences developing brain Development. Metamorphosis. Moult. Ageing Fundamental and applied biological sciences. Psychology muscarinic receptors triiodothyronine Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effect of Triiodothryonine on the Muscarinic Receptors and Acetylcholinesterase Activity of Developing Rat Brain |
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