Metachromatic Cells and Eosinophils in the Nasal Mucosa and N,N-Dimethylbenzylamine Exposure
Irander K, Ståhlbom B, Welinder H, Åkesson B. Metachromatic cells and eosinophils in the nasal mucosa and N,N-dimethyl-benzylamine exposure. Acta Otolaryngol (Stockh) 1997; 117: 433-436. Six healthy non-atopic male volunteers participated in a dose-response study of N,N-dimethylbenzylamine (DMBA), w...
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| creator | Irander, Krishna Ståhlbom, Bengt Welinder, Hans Åkesson, Bengt |
| description | Irander K, Ståhlbom B, Welinder H, Åkesson B. Metachromatic cells and eosinophils in the nasal mucosa and N,N-dimethyl-benzylamine exposure. Acta Otolaryngol (Stockh) 1997; 117: 433-436.
Six healthy non-atopic male volunteers participated in a dose-response study of N,N-dimethylbenzylamine (DMBA), which is a reactive chemical used in epoxy systems. The effects on the nasal mucosa after inhalation of 0, 20, 45, 80 and 120 /ig/m3 were studied by means of symptom recordings, acoustic rhinometry, nasal lavages and nasal cytology processed for light microscopy of metachromatic cells (MC) and eosinophils (EOS). Although only minor symptoms were provoked, the numbers of MC and Eos tended to increase in a dose-response fashion after inhalation of the chemical. No signs of degranulation of the cells were found, as the levels of tryptase and eosinophil cationic protein in the nasal lavages remained low at all DMBA exposure levels. We therefore conclude that a reactive chemical such as DMBA can influence MC and Eos in the nasal mucosa even at low dose levels without causing significant clinical symptoms. |
| doi_str_mv | 10.3109/00016489709113417 |
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Six healthy non-atopic male volunteers participated in a dose-response study of N,N-dimethylbenzylamine (DMBA), which is a reactive chemical used in epoxy systems. The effects on the nasal mucosa after inhalation of 0, 20, 45, 80 and 120 /ig/m3 were studied by means of symptom recordings, acoustic rhinometry, nasal lavages and nasal cytology processed for light microscopy of metachromatic cells (MC) and eosinophils (EOS). Although only minor symptoms were provoked, the numbers of MC and Eos tended to increase in a dose-response fashion after inhalation of the chemical. No signs of degranulation of the cells were found, as the levels of tryptase and eosinophil cationic protein in the nasal lavages remained low at all DMBA exposure levels. We therefore conclude that a reactive chemical such as DMBA can influence MC and Eos in the nasal mucosa even at low dose levels without causing significant clinical symptoms.</description><identifier>ISSN: 0001-6489</identifier><identifier>EISSN: 1651-2251</identifier><identifier>DOI: 10.3109/00016489709113417</identifier><identifier>PMID: 9199531</identifier><identifier>CODEN: AOLAAJ</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>9,10-Dimethyl-1,2-benzanthracene - administration & dosage ; 9,10-Dimethyl-1,2-benzanthracene - pharmacology ; Administration, Inhalation ; Adult ; Amines ; Biological and medical sciences ; Bronchial Provocation Tests ; Carcinogens - administration & dosage ; Carcinogens - pharmacology ; Cell Count ; Dose-Response Relationship, Drug ; Eosinophils - drug effects ; epoxy ; Humans ; Hyperreactivity ; Male ; Medical sciences ; Nasal Lavage Fluid - cytology ; nasal mucosa ; Nasal Mucosa - cytology ; Nasal Mucosa - drug effects ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Acta oto-laryngologica, 1997, Vol.117 (3), p.433-436</ispartof><rights>1997 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-f9f11990b4a97352a3eed3e3c3b4876bbbee78e282399927616a2993f8c708ed3</citedby><cites>FETCH-LOGICAL-c430t-f9f11990b4a97352a3eed3e3c3b4876bbbee78e282399927616a2993f8c708ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00016489709113417$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00016489709113417$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2666782$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9199531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irander, Krishna</creatorcontrib><creatorcontrib>Ståhlbom, Bengt</creatorcontrib><creatorcontrib>Welinder, Hans</creatorcontrib><creatorcontrib>Åkesson, Bengt</creatorcontrib><title>Metachromatic Cells and Eosinophils in the Nasal Mucosa and N,N-Dimethylbenzylamine Exposure</title><title>Acta oto-laryngologica</title><addtitle>Acta Otolaryngol</addtitle><description>Irander K, Ståhlbom B, Welinder H, Åkesson B. Metachromatic cells and eosinophils in the nasal mucosa and N,N-dimethyl-benzylamine exposure. Acta Otolaryngol (Stockh) 1997; 117: 433-436.
Six healthy non-atopic male volunteers participated in a dose-response study of N,N-dimethylbenzylamine (DMBA), which is a reactive chemical used in epoxy systems. The effects on the nasal mucosa after inhalation of 0, 20, 45, 80 and 120 /ig/m3 were studied by means of symptom recordings, acoustic rhinometry, nasal lavages and nasal cytology processed for light microscopy of metachromatic cells (MC) and eosinophils (EOS). Although only minor symptoms were provoked, the numbers of MC and Eos tended to increase in a dose-response fashion after inhalation of the chemical. No signs of degranulation of the cells were found, as the levels of tryptase and eosinophil cationic protein in the nasal lavages remained low at all DMBA exposure levels. We therefore conclude that a reactive chemical such as DMBA can influence MC and Eos in the nasal mucosa even at low dose levels without causing significant clinical symptoms.</description><subject>9,10-Dimethyl-1,2-benzanthracene - administration & dosage</subject><subject>9,10-Dimethyl-1,2-benzanthracene - pharmacology</subject><subject>Administration, Inhalation</subject><subject>Adult</subject><subject>Amines</subject><subject>Biological and medical sciences</subject><subject>Bronchial Provocation Tests</subject><subject>Carcinogens - administration & dosage</subject><subject>Carcinogens - pharmacology</subject><subject>Cell Count</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eosinophils - drug effects</subject><subject>epoxy</subject><subject>Humans</subject><subject>Hyperreactivity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nasal Lavage Fluid - cytology</subject><subject>nasal mucosa</subject><subject>Nasal Mucosa - cytology</subject><subject>Nasal Mucosa - drug effects</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0001-6489</issn><issn>1651-2251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1Lw0AQxRdRaq3-AR6EHDwa3c3ma9GL1PoBbb3oTQiTzYRs2WTLboLWv97UVkGEnobh_d7w5hFyyuglZ1RcUUpZHKYioYIxHrJkjwxZHDE_CCK2T4Zr3V8Dh-TIucV6FWk0IAPBhIg4G5K3GbYgK2tqaJX0xqi186ApvIlxqjHLSvW7ary2Qm8ODrQ366Rx8M3ML-b-naqxrVY6x-ZzpaFWDXqTj6VxncVjclCCdniynSPyej95GT_60-eHp_Ht1Jchp61fipL1eWgegkh4FABHLDhyyfMwTeI8zxGTFIM04EKIIIlZDIEQvExlQtMeHRG2uSutcc5imS2tqsGuMkazdVHZv6J6z9nGs-zyGotfx7aZXj_f6uAk6NJCI5X7xYI4jpM-0IjcbDDVlMbW8G6sLrIWVtrYHw_fleL6j71C0G0lwWK2MJ1t-tZ2_PAFlOWVGQ</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Irander, Krishna</creator><creator>Ståhlbom, Bengt</creator><creator>Welinder, Hans</creator><creator>Åkesson, Bengt</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1997</creationdate><title>Metachromatic Cells and Eosinophils in the Nasal Mucosa and N,N-Dimethylbenzylamine Exposure</title><author>Irander, Krishna ; Ståhlbom, Bengt ; Welinder, Hans ; Åkesson, Bengt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-f9f11990b4a97352a3eed3e3c3b4876bbbee78e282399927616a2993f8c708ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene - administration & dosage</topic><topic>9,10-Dimethyl-1,2-benzanthracene - pharmacology</topic><topic>Administration, Inhalation</topic><topic>Adult</topic><topic>Amines</topic><topic>Biological and medical sciences</topic><topic>Bronchial Provocation Tests</topic><topic>Carcinogens - administration & dosage</topic><topic>Carcinogens - pharmacology</topic><topic>Cell Count</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eosinophils - drug effects</topic><topic>epoxy</topic><topic>Humans</topic><topic>Hyperreactivity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nasal Lavage Fluid - cytology</topic><topic>nasal mucosa</topic><topic>Nasal Mucosa - cytology</topic><topic>Nasal Mucosa - drug effects</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Irander, Krishna</creatorcontrib><creatorcontrib>Ståhlbom, Bengt</creatorcontrib><creatorcontrib>Welinder, Hans</creatorcontrib><creatorcontrib>Åkesson, Bengt</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta oto-laryngologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Irander, Krishna</au><au>Ståhlbom, Bengt</au><au>Welinder, Hans</au><au>Åkesson, Bengt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metachromatic Cells and Eosinophils in the Nasal Mucosa and N,N-Dimethylbenzylamine Exposure</atitle><jtitle>Acta oto-laryngologica</jtitle><addtitle>Acta Otolaryngol</addtitle><date>1997</date><risdate>1997</risdate><volume>117</volume><issue>3</issue><spage>433</spage><epage>436</epage><pages>433-436</pages><issn>0001-6489</issn><eissn>1651-2251</eissn><coden>AOLAAJ</coden><abstract>Irander K, Ståhlbom B, Welinder H, Åkesson B. Metachromatic cells and eosinophils in the nasal mucosa and N,N-dimethyl-benzylamine exposure. Acta Otolaryngol (Stockh) 1997; 117: 433-436.
Six healthy non-atopic male volunteers participated in a dose-response study of N,N-dimethylbenzylamine (DMBA), which is a reactive chemical used in epoxy systems. The effects on the nasal mucosa after inhalation of 0, 20, 45, 80 and 120 /ig/m3 were studied by means of symptom recordings, acoustic rhinometry, nasal lavages and nasal cytology processed for light microscopy of metachromatic cells (MC) and eosinophils (EOS). Although only minor symptoms were provoked, the numbers of MC and Eos tended to increase in a dose-response fashion after inhalation of the chemical. No signs of degranulation of the cells were found, as the levels of tryptase and eosinophil cationic protein in the nasal lavages remained low at all DMBA exposure levels. We therefore conclude that a reactive chemical such as DMBA can influence MC and Eos in the nasal mucosa even at low dose levels without causing significant clinical symptoms.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>9199531</pmid><doi>10.3109/00016489709113417</doi><tpages>4</tpages></addata></record> |
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| subjects | 9,10-Dimethyl-1,2-benzanthracene - administration & dosage 9,10-Dimethyl-1,2-benzanthracene - pharmacology Administration, Inhalation Adult Amines Biological and medical sciences Bronchial Provocation Tests Carcinogens - administration & dosage Carcinogens - pharmacology Cell Count Dose-Response Relationship, Drug Eosinophils - drug effects epoxy Humans Hyperreactivity Male Medical sciences Nasal Lavage Fluid - cytology nasal mucosa Nasal Mucosa - cytology Nasal Mucosa - drug effects Non tumoral diseases Otorhinolaryngology. Stomatology Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Metachromatic Cells and Eosinophils in the Nasal Mucosa and N,N-Dimethylbenzylamine Exposure |
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