Effects of Salicylate on Shape, Electromotility and Membrane Characteristics of Isolated Outer Hair Cells from Guinea Pig Cochlea

A reversible tinnitus and hearing loss have long been known to result from large doses of salicylate. Cochlear electrophysiology and otoacoustic emission studies suggest that the drug may interfere with outer hair cell electromotility. Exposure of isolated outer hair cells to sodium salicylate conce...

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Veröffentlicht in:	Acta oto-laryngologica 1991, Vol.111 (3), p.707-718
Hauptverfasser:	Shehata, W. E., Brownell, W. E., Dieler, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aspirin Biological and medical sciences Cochlear Microphonic Potentials - drug effects Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Electric Conductivity - drug effects Electrophysiology Guinea Pigs Hair Cells, Auditory - drug effects Hair Cells, Auditory - physiopathology hearing loss In Vitro Techniques Medical sciences membrane conductance Miscellaneous (drug allergy, mutagens, teratogens...) morphometric analysis otoacoustic emissions Pharmacology. Drug treatments Sodium Salicylate - pharmacology turgor whole cell recording
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