In vitro Synthesis of IgE Antibody by Human Tonsil Mononuclear Cells: Preliminary Report
Using anti-human IgE monoclonal antibody E235I63, an IgE antibody to mite extract response by peripheral blood lymphocytes (PBL) and tonsillar lymphoid cells from 3 atopic patients suffering nasal allergy and 2 normal individuals was detected by a sensitive radioimmunoassay of culture supernatants....
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| Veröffentlicht in: | Acta oto-laryngologica 1988, Vol.105 (S454), p.133-137 |
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| container_end_page | 137 |
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| container_issue | S454 |
| container_start_page | 133 |
| container_title | Acta oto-laryngologica |
| container_volume | 105 |
| creator | Takenaka, Hiroshi Kusumi, Taeko Mizukoshi, Osamu |
| description | Using anti-human IgE monoclonal antibody E235I63, an IgE antibody to mite extract response by peripheral blood lymphocytes (PBL) and tonsillar lymphoid cells from 3 atopic patients suffering nasal allergy and 2 normal individuals was detected by a sensitive radioimmunoassay of culture supernatants. Although the spontaneous IgE antibody response was characteristic of atopic PBL, PBL of normal controls did not produce anti-mite IgE antibody spontaneously. IgE antibody to mite extracts were detected in supernatants of all tonsillar cells cultured with mite antigen or PWM, but PBL from only atopic donors could produce IgE antibody in the same conditions. |
| doi_str_mv | 10.3109/00016488809125016 |
| format | Article |
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Although the spontaneous IgE antibody response was characteristic of atopic PBL, PBL of normal controls did not produce anti-mite IgE antibody spontaneously. 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Although the spontaneous IgE antibody response was characteristic of atopic PBL, PBL of normal controls did not produce anti-mite IgE antibody spontaneously. IgE antibody to mite extracts were detected in supernatants of all tonsillar cells cultured with mite antigen or PWM, but PBL from only atopic donors could produce IgE antibody in the same conditions.</description><subject>mite extracts</subject><subject>monoclonal anti-human IgE antibody</subject><issn>0001-6489</issn><issn>1651-2251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNp9kM9KAzEQxoMoWKsP4C0vsJpkN9useilFbaGiaAVvS_7alGxSkq2yb-8u9SKip5lh5jffzAfAOUYXOUbVJUIIlwVjDFWY0D4_ACNcUpwRQvEhGA39rB-ojsFJSpuhrBgdgbeFhx-2jQG-dL5d62QTDAYu3m_h1LdWBNVB0cH5ruEeroJP1sGH4IPfSad5hDPtXLqCT1E721jPYwef9TbE9hQcGe6SPvuOY_B6d7uazbPl4_1iNl1mkpS0zTBXUkhBtFGsKgrFsaoMoiSX2lRIl4URghJMDZlIU-YmZ9JMEBdMMJIrwvMxwPu9MoaUojb1Ntqmv6PGqB6sqX9Z0zM3e8Z6E2LDP0N0qm5550I0kXtp04D-jV__wNeau3YtedT1Juyi79_9R_wLval9Gg</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Takenaka, Hiroshi</creator><creator>Kusumi, Taeko</creator><creator>Mizukoshi, Osamu</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1988</creationdate><title>In vitro Synthesis of IgE Antibody by Human Tonsil Mononuclear Cells: Preliminary Report</title><author>Takenaka, Hiroshi ; Kusumi, Taeko ; Mizukoshi, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c265t-1adcbcb2efd8944da1d9f0523cef90e64fbb5215f27cf63f38cf70ab8b823d2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>mite extracts</topic><topic>monoclonal anti-human IgE antibody</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takenaka, Hiroshi</creatorcontrib><creatorcontrib>Kusumi, Taeko</creatorcontrib><creatorcontrib>Mizukoshi, Osamu</creatorcontrib><collection>CrossRef</collection><jtitle>Acta oto-laryngologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takenaka, Hiroshi</au><au>Kusumi, Taeko</au><au>Mizukoshi, Osamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro Synthesis of IgE Antibody by Human Tonsil Mononuclear Cells: Preliminary Report</atitle><jtitle>Acta oto-laryngologica</jtitle><date>1988</date><risdate>1988</risdate><volume>105</volume><issue>S454</issue><spage>133</spage><epage>137</epage><pages>133-137</pages><issn>0001-6489</issn><eissn>1651-2251</eissn><abstract>Using anti-human IgE monoclonal antibody E235I63, an IgE antibody to mite extract response by peripheral blood lymphocytes (PBL) and tonsillar lymphoid cells from 3 atopic patients suffering nasal allergy and 2 normal individuals was detected by a sensitive radioimmunoassay of culture supernatants. Although the spontaneous IgE antibody response was characteristic of atopic PBL, PBL of normal controls did not produce anti-mite IgE antibody spontaneously. IgE antibody to mite extracts were detected in supernatants of all tonsillar cells cultured with mite antigen or PWM, but PBL from only atopic donors could produce IgE antibody in the same conditions.</abstract><pub>Informa UK Ltd</pub><doi>10.3109/00016488809125016</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6489 |
| ispartof | Acta oto-laryngologica, 1988, Vol.105 (S454), p.133-137 |
| issn | 0001-6489 1651-2251 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_00016488809125016 |
| source | Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | mite extracts monoclonal anti-human IgE antibody |
| title | In vitro Synthesis of IgE Antibody by Human Tonsil Mononuclear Cells: Preliminary Report |
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