Albumin inhibits effects of Cu2+ on autonomic postganglionic transmission of guinea-pig ileum and vas deferens
The influence of albumin, 4.5 and 45g/l, on the effects of Cu2+, 10−9-10−3M, on the neuromuscular transmission of the isolated guinea-pig ileum and vas deferens was investigated. Low concentrations of Cu2+, 10−9-10−6M, caused a slight and transient increase of the contractile response to direct musc...
Gespeichert in:
| Veröffentlicht in: | Acta odontologica Scandinavica 1991-12, Vol.49 (6), p.361-366 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 366 |
|---|---|
| container_issue | 6 |
| container_start_page | 361 |
| container_title | Acta odontologica Scandinavica |
| container_volume | 49 |
| creator | Moberg, Lars-Erik Appelgren, Björn Sjöstrand, Nils O. |
| description | The influence of albumin, 4.5 and 45g/l, on the effects of Cu2+, 10−9-10−3M, on the neuromuscular transmission of the isolated guinea-pig ileum and vas deferens was investigated. Low concentrations of Cu2+, 10−9-10−6M, caused a slight and transient increase of the contractile response to direct muscle stimulation of the vas deferens. Albumin at 4.5 g/l inhibited this effect. The basal tone of the ileum increased transiently when Cu2+ was added in the presence of albumin, 4.5 g/l. A stimulant action of Cu2+, 10−9-10−6M, was seen on both organs, when contractions were induced by nerve stimulation. All these effects were inhibited by albumin, 45 g/l. Higher concentrations of Cu2+, 10−5-10−4 M, increased the basal tone of the ileum and the vas deferens. In the presence of albumin, 45 g/l, this stimulating effect of Cu2+ appeared in higher concentrations. The results suggest that Cu2+ is more likely to influence the function of neuronal tissues when the concentration of protein is low. |
| doi_str_mv | 10.3109/00016359109005932 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_informahealthcare_journals_10_3109_00016359109005932</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72614757</sourcerecordid><originalsourceid>FETCH-LOGICAL-i243t-e4edf34f78eab83103460474a6a01a5da0d0b798fd35977cc327655893a52523</originalsourceid><addsrcrecordid>eNp1UcFq3DAQFSUl3Wz7AT0UdMqluJUtybJpLmFp0sJCL7mLsT3aVZClrWQl5O-jJXsJIQcxerz3hnkzhHyt2Q9es_4nY6xuuezLnzHZ8-YDWdWSNRXvJDsjqyNfFYH6RC5Sui9Q9F1_Ts5rpVrB-Ir4azfk2Xpq_d4OdkkUjcGx1GDoJjffafAU8hJ8mO1IDyEtO_A7Z4MvcIng02xTKvBo2GXrEaqD3VHrMM8U_EQfINEJDUb06TP5aMAl_HKqa3J38_tu86fa_rv9u7neVrYRfKlQ4GS4MKpDGLoSlYuWCSWgBVaDnIBNbFB9Z6YSXqlx5I1qpex6DrKRDV-Ty5e2hxj-Z0yLLkOO6Bx4DDlp1bS1UFIV4beTMA8zTvoQ7QzxSZ_2U_irF956E-IMjyG6SS_w5EI0Jfxoky7jHV-v31yj2H-9su8R3LIfIaK-Dzn6sgL9vvsZ_q-NlQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72614757</pqid></control><display><type>article</type><title>Albumin inhibits effects of Cu2+ on autonomic postganglionic transmission of guinea-pig ileum and vas deferens</title><source>MEDLINE</source><source>Taylor & Francis:Master (3349 titles)</source><source>Taylor & Francis Medical Library - CRKN</source><source>Alma/SFX Local Collection</source><creator>Moberg, Lars-Erik ; Appelgren, Björn ; Sjöstrand, Nils O.</creator><creatorcontrib>Moberg, Lars-Erik ; Appelgren, Björn ; Sjöstrand, Nils O.</creatorcontrib><description>The influence of albumin, 4.5 and 45g/l, on the effects of Cu2+, 10−9-10−3M, on the neuromuscular transmission of the isolated guinea-pig ileum and vas deferens was investigated. Low concentrations of Cu2+, 10−9-10−6M, caused a slight and transient increase of the contractile response to direct muscle stimulation of the vas deferens. Albumin at 4.5 g/l inhibited this effect. The basal tone of the ileum increased transiently when Cu2+ was added in the presence of albumin, 4.5 g/l. A stimulant action of Cu2+, 10−9-10−6M, was seen on both organs, when contractions were induced by nerve stimulation. All these effects were inhibited by albumin, 45 g/l. Higher concentrations of Cu2+, 10−5-10−4 M, increased the basal tone of the ileum and the vas deferens. In the presence of albumin, 45 g/l, this stimulating effect of Cu2+ appeared in higher concentrations. The results suggest that Cu2+ is more likely to influence the function of neuronal tissues when the concentration of protein is low.</description><identifier>ISSN: 0001-6357</identifier><identifier>EISSN: 1502-3850</identifier><identifier>DOI: 10.3109/00016359109005932</identifier><identifier>PMID: 1776403</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adrenergic Antagonists ; Albumins - pharmacology ; Amalgam ; Animals ; Autonomic Fibers, Postganglionic - drug effects ; Cholinergic Antagonists ; copper ; Copper - antagonists & inhibitors ; Copper - pharmacology ; Dentistry ; Guinea Pigs ; Ileum - drug effects ; Male ; Muscle, Smooth - drug effects ; neuro-muscular transmission ; Neuromuscular Blocking Agents ; smooth muscle ; Vas Deferens - drug effects</subject><ispartof>Acta odontologica Scandinavica, 1991-12, Vol.49 (6), p.361-366</ispartof><rights>1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00016359109005932$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00016359109005932$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,59645,59751,60434,60540,61219,61254,61400,61435</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1776403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moberg, Lars-Erik</creatorcontrib><creatorcontrib>Appelgren, Björn</creatorcontrib><creatorcontrib>Sjöstrand, Nils O.</creatorcontrib><title>Albumin inhibits effects of Cu2+ on autonomic postganglionic transmission of guinea-pig ileum and vas deferens</title><title>Acta odontologica Scandinavica</title><addtitle>Acta Odontol Scand</addtitle><description>The influence of albumin, 4.5 and 45g/l, on the effects of Cu2+, 10−9-10−3M, on the neuromuscular transmission of the isolated guinea-pig ileum and vas deferens was investigated. Low concentrations of Cu2+, 10−9-10−6M, caused a slight and transient increase of the contractile response to direct muscle stimulation of the vas deferens. Albumin at 4.5 g/l inhibited this effect. The basal tone of the ileum increased transiently when Cu2+ was added in the presence of albumin, 4.5 g/l. A stimulant action of Cu2+, 10−9-10−6M, was seen on both organs, when contractions were induced by nerve stimulation. All these effects were inhibited by albumin, 45 g/l. Higher concentrations of Cu2+, 10−5-10−4 M, increased the basal tone of the ileum and the vas deferens. In the presence of albumin, 45 g/l, this stimulating effect of Cu2+ appeared in higher concentrations. The results suggest that Cu2+ is more likely to influence the function of neuronal tissues when the concentration of protein is low.</description><subject>Adrenergic Antagonists</subject><subject>Albumins - pharmacology</subject><subject>Amalgam</subject><subject>Animals</subject><subject>Autonomic Fibers, Postganglionic - drug effects</subject><subject>Cholinergic Antagonists</subject><subject>copper</subject><subject>Copper - antagonists & inhibitors</subject><subject>Copper - pharmacology</subject><subject>Dentistry</subject><subject>Guinea Pigs</subject><subject>Ileum - drug effects</subject><subject>Male</subject><subject>Muscle, Smooth - drug effects</subject><subject>neuro-muscular transmission</subject><subject>Neuromuscular Blocking Agents</subject><subject>smooth muscle</subject><subject>Vas Deferens - drug effects</subject><issn>0001-6357</issn><issn>1502-3850</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UcFq3DAQFSUl3Wz7AT0UdMqluJUtybJpLmFp0sJCL7mLsT3aVZClrWQl5O-jJXsJIQcxerz3hnkzhHyt2Q9es_4nY6xuuezLnzHZ8-YDWdWSNRXvJDsjqyNfFYH6RC5Sui9Q9F1_Ts5rpVrB-Ir4azfk2Xpq_d4OdkkUjcGx1GDoJjffafAU8hJ8mO1IDyEtO_A7Z4MvcIng02xTKvBo2GXrEaqD3VHrMM8U_EQfINEJDUb06TP5aMAl_HKqa3J38_tu86fa_rv9u7neVrYRfKlQ4GS4MKpDGLoSlYuWCSWgBVaDnIBNbFB9Z6YSXqlx5I1qpex6DrKRDV-Ty5e2hxj-Z0yLLkOO6Bx4DDlp1bS1UFIV4beTMA8zTvoQ7QzxSZ_2U_irF956E-IMjyG6SS_w5EI0Jfxoky7jHV-v31yj2H-9su8R3LIfIaK-Dzn6sgL9vvsZ_q-NlQ</recordid><startdate>19911201</startdate><enddate>19911201</enddate><creator>Moberg, Lars-Erik</creator><creator>Appelgren, Björn</creator><creator>Sjöstrand, Nils O.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19911201</creationdate><title>Albumin inhibits effects of Cu2+ on autonomic postganglionic transmission of guinea-pig ileum and vas deferens</title><author>Moberg, Lars-Erik ; Appelgren, Björn ; Sjöstrand, Nils O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i243t-e4edf34f78eab83103460474a6a01a5da0d0b798fd35977cc327655893a52523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adrenergic Antagonists</topic><topic>Albumins - pharmacology</topic><topic>Amalgam</topic><topic>Animals</topic><topic>Autonomic Fibers, Postganglionic - drug effects</topic><topic>Cholinergic Antagonists</topic><topic>copper</topic><topic>Copper - antagonists & inhibitors</topic><topic>Copper - pharmacology</topic><topic>Dentistry</topic><topic>Guinea Pigs</topic><topic>Ileum - drug effects</topic><topic>Male</topic><topic>Muscle, Smooth - drug effects</topic><topic>neuro-muscular transmission</topic><topic>Neuromuscular Blocking Agents</topic><topic>smooth muscle</topic><topic>Vas Deferens - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moberg, Lars-Erik</creatorcontrib><creatorcontrib>Appelgren, Björn</creatorcontrib><creatorcontrib>Sjöstrand, Nils O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta odontologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moberg, Lars-Erik</au><au>Appelgren, Björn</au><au>Sjöstrand, Nils O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Albumin inhibits effects of Cu2+ on autonomic postganglionic transmission of guinea-pig ileum and vas deferens</atitle><jtitle>Acta odontologica Scandinavica</jtitle><addtitle>Acta Odontol Scand</addtitle><date>1991-12-01</date><risdate>1991</risdate><volume>49</volume><issue>6</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>0001-6357</issn><eissn>1502-3850</eissn><abstract>The influence of albumin, 4.5 and 45g/l, on the effects of Cu2+, 10−9-10−3M, on the neuromuscular transmission of the isolated guinea-pig ileum and vas deferens was investigated. Low concentrations of Cu2+, 10−9-10−6M, caused a slight and transient increase of the contractile response to direct muscle stimulation of the vas deferens. Albumin at 4.5 g/l inhibited this effect. The basal tone of the ileum increased transiently when Cu2+ was added in the presence of albumin, 4.5 g/l. A stimulant action of Cu2+, 10−9-10−6M, was seen on both organs, when contractions were induced by nerve stimulation. All these effects were inhibited by albumin, 45 g/l. Higher concentrations of Cu2+, 10−5-10−4 M, increased the basal tone of the ileum and the vas deferens. In the presence of albumin, 45 g/l, this stimulating effect of Cu2+ appeared in higher concentrations. The results suggest that Cu2+ is more likely to influence the function of neuronal tissues when the concentration of protein is low.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>1776403</pmid><doi>10.3109/00016359109005932</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6357 |
| ispartof | Acta odontologica Scandinavica, 1991-12, Vol.49 (6), p.361-366 |
| issn | 0001-6357 1502-3850 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_00016359109005932 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN; Alma/SFX Local Collection |
| subjects | Adrenergic Antagonists Albumins - pharmacology Amalgam Animals Autonomic Fibers, Postganglionic - drug effects Cholinergic Antagonists copper Copper - antagonists & inhibitors Copper - pharmacology Dentistry Guinea Pigs Ileum - drug effects Male Muscle, Smooth - drug effects neuro-muscular transmission Neuromuscular Blocking Agents smooth muscle Vas Deferens - drug effects |
| title | Albumin inhibits effects of Cu2+ on autonomic postganglionic transmission of guinea-pig ileum and vas deferens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T23%3A11%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Albumin%20inhibits%20effects%20of%20Cu2+%20on%20autonomic%20postganglionic%20transmission%20of%20guinea-pig%20ileum%20and%20vas%20deferens&rft.jtitle=Acta%20odontologica%20Scandinavica&rft.au=Moberg,%20Lars-Erik&rft.date=1991-12-01&rft.volume=49&rft.issue=6&rft.spage=361&rft.epage=366&rft.pages=361-366&rft.issn=0001-6357&rft.eissn=1502-3850&rft_id=info:doi/10.3109/00016359109005932&rft_dat=%3Cproquest_infor%3E72614757%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72614757&rft_id=info:pmid/1776403&rfr_iscdi=true |