Evaluation of tolmetin in the treatment of active chronic rheumatoid arthritis open and controlled double-blind studies
Summary In a 6-week open study in 24 patients with rheumatoid arthritis, tolmetin was shown to have analgesic and anti-inflammatory activity at daily doses in excess of 1200 mg per day and produced statistically significant reductions in overall joint pain, walking time and articular index. The drug...
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| Veröffentlicht in: | Current medical research and opinion 1976, Vol.4 (2), p.158-169 |
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| container_end_page | 169 |
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| container_issue | 2 |
| container_start_page | 158 |
| container_title | Current medical research and opinion |
| container_volume | 4 |
| creator | Aylward, Mansel Maddock, Jeffrey Parker, R. J. Thomas, Sandra R. Holly, F. |
| description | Summary
In a 6-week open study in 24 patients with rheumatoid arthritis, tolmetin was shown to have analgesic and anti-inflammatory activity at daily doses in excess of 1200 mg per day and produced statistically significant reductions in overall joint pain, walking time and articular index. The drug was well tolerated, but 2 patients were withdrawn because of persistent indigestion and 1 because of an urticarial type rash.
In a double-blind crossover comparison against indomethacin and placebo in 22 patients, 1400 mg tolmetin daily showed efficacy comparable with that of 150 mg indomethacin daily. Few side-effects were reported and did not necessitate any patients being withdrawn. |
| doi_str_mv | 10.1185/03007997609109297 |
| format | Article |
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In a 6-week open study in 24 patients with rheumatoid arthritis, tolmetin was shown to have analgesic and anti-inflammatory activity at daily doses in excess of 1200 mg per day and produced statistically significant reductions in overall joint pain, walking time and articular index. The drug was well tolerated, but 2 patients were withdrawn because of persistent indigestion and 1 because of an urticarial type rash.
In a double-blind crossover comparison against indomethacin and placebo in 22 patients, 1400 mg tolmetin daily showed efficacy comparable with that of 150 mg indomethacin daily. Few side-effects were reported and did not necessitate any patients being withdrawn.</description><identifier>ISSN: 0300-7995</identifier><identifier>EISSN: 1473-4877</identifier><identifier>DOI: 10.1185/03007997609109297</identifier><language>eng</language><publisher>Informa UK Ltd</publisher><subject>anti-inflammatory agents ; Arthritis ; indomethacin ; rheumatoid ; tolmetin</subject><ispartof>Current medical research and opinion, 1976, Vol.4 (2), p.158-169</ispartof><rights>1976 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c263t-238c831c08e51dcbab694f056960c2a03f91193adac35b1f8ef6986c6e3bfff03</citedby><cites>FETCH-LOGICAL-c263t-238c831c08e51dcbab694f056960c2a03f91193adac35b1f8ef6986c6e3bfff03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1185/03007997609109297$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1185/03007997609109297$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids></links><search><creatorcontrib>Aylward, Mansel</creatorcontrib><creatorcontrib>Maddock, Jeffrey</creatorcontrib><creatorcontrib>Parker, R. J.</creatorcontrib><creatorcontrib>Thomas, Sandra R.</creatorcontrib><creatorcontrib>Holly, F.</creatorcontrib><title>Evaluation of tolmetin in the treatment of active chronic rheumatoid arthritis open and controlled double-blind studies</title><title>Current medical research and opinion</title><description>Summary
In a 6-week open study in 24 patients with rheumatoid arthritis, tolmetin was shown to have analgesic and anti-inflammatory activity at daily doses in excess of 1200 mg per day and produced statistically significant reductions in overall joint pain, walking time and articular index. The drug was well tolerated, but 2 patients were withdrawn because of persistent indigestion and 1 because of an urticarial type rash.
In a double-blind crossover comparison against indomethacin and placebo in 22 patients, 1400 mg tolmetin daily showed efficacy comparable with that of 150 mg indomethacin daily. Few side-effects were reported and did not necessitate any patients being withdrawn.</description><subject>anti-inflammatory agents</subject><subject>Arthritis</subject><subject>indomethacin</subject><subject>rheumatoid</subject><subject>tolmetin</subject><issn>0300-7995</issn><issn>1473-4877</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><recordid>eNp9kN1KAzEQhYMoWKsP4F1eYDXZdH-C3kipP1DwRq-X2eyETckmJcm29O3dUm9EKAwMzJlvDnMIuefsgfO6eGSCsUrKqmSSM5nL6oLM-KIS2aKuqksyO-rZtFBck5sYN4zxvJZyRvarHdgRkvGOek2TtwMm4-hUqUeaAkIa0KWjCCqZHVLVB--MoqHHcYDkTUchpD6YZCL1W3QUXEeVdyl4a7GjnR9bi1lrzTSPaewMxltypcFGvPvtc_L9uvpavmfrz7eP5cs6U3kpUpaLWtWCK1ZjwTvVQlvKhWZFKUumcmBCS86lgA6UKFqua9SlrEtVomi11kzMCT_dVcHHGFA322AGCIeGs-aYXPMvuYl5PjHGaR8G2PtguybBwfqgAzhlYiPO4U9_8B7Bpl5BwGbjx-Cmd8-Y_wAjqom4</recordid><startdate>1976</startdate><enddate>1976</enddate><creator>Aylward, Mansel</creator><creator>Maddock, Jeffrey</creator><creator>Parker, R. J.</creator><creator>Thomas, Sandra R.</creator><creator>Holly, F.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1976</creationdate><title>Evaluation of tolmetin in the treatment of active chronic rheumatoid arthritis open and controlled double-blind studies</title><author>Aylward, Mansel ; Maddock, Jeffrey ; Parker, R. J. ; Thomas, Sandra R. ; Holly, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c263t-238c831c08e51dcbab694f056960c2a03f91193adac35b1f8ef6986c6e3bfff03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>anti-inflammatory agents</topic><topic>Arthritis</topic><topic>indomethacin</topic><topic>rheumatoid</topic><topic>tolmetin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aylward, Mansel</creatorcontrib><creatorcontrib>Maddock, Jeffrey</creatorcontrib><creatorcontrib>Parker, R. J.</creatorcontrib><creatorcontrib>Thomas, Sandra R.</creatorcontrib><creatorcontrib>Holly, F.</creatorcontrib><collection>CrossRef</collection><jtitle>Current medical research and opinion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aylward, Mansel</au><au>Maddock, Jeffrey</au><au>Parker, R. J.</au><au>Thomas, Sandra R.</au><au>Holly, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of tolmetin in the treatment of active chronic rheumatoid arthritis open and controlled double-blind studies</atitle><jtitle>Current medical research and opinion</jtitle><date>1976</date><risdate>1976</risdate><volume>4</volume><issue>2</issue><spage>158</spage><epage>169</epage><pages>158-169</pages><issn>0300-7995</issn><eissn>1473-4877</eissn><abstract>Summary
In a 6-week open study in 24 patients with rheumatoid arthritis, tolmetin was shown to have analgesic and anti-inflammatory activity at daily doses in excess of 1200 mg per day and produced statistically significant reductions in overall joint pain, walking time and articular index. The drug was well tolerated, but 2 patients were withdrawn because of persistent indigestion and 1 because of an urticarial type rash.
In a double-blind crossover comparison against indomethacin and placebo in 22 patients, 1400 mg tolmetin daily showed efficacy comparable with that of 150 mg indomethacin daily. Few side-effects were reported and did not necessitate any patients being withdrawn.</abstract><pub>Informa UK Ltd</pub><doi>10.1185/03007997609109297</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-7995 |
| ispartof | Current medical research and opinion, 1976, Vol.4 (2), p.158-169 |
| issn | 0300-7995 1473-4877 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_1185_03007997609109297 |
| source | Taylor & Francis; Taylor & Francis Medical Library - CRKN |
| subjects | anti-inflammatory agents Arthritis indomethacin rheumatoid tolmetin |
| title | Evaluation of tolmetin in the treatment of active chronic rheumatoid arthritis open and controlled double-blind studies |
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