A Study of the Impact of Freezing on the Lyophilization of a Concentrated Formulation with a High Fill Depth

The objective of this study was to evaluate the impact of freezing on the lyophilization of a concentrated formulation with a high fill depth. A model system consisting of a 15-mL fill of 15% (w/w) sulfobutylether 7-beta-cyclodextrin (SBECD) solution in a 30-mL vial was selected for this study. Vari...

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Veröffentlicht in:	Pharmaceutical development and technology 2005-01, Vol.10 (2), p.261-272
Hauptverfasser:	Liu, Jinsong, Viverette, Todd, Virgin, Marlin, Anderson, Mitch, Dalal, Paresh
Format:	Artikel
Sprache:	eng
Schlagworte:	Cycle optimization Freeze-drying Freezing process Lyophilization Product quality
Online-Zugang:	Volltext
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