Monitoring the Retention of a Protein Antigen in Complete Freund's Adjuvant, Alum, and Pluronic F-127 Gel Formulations by X-ray Fluorescence

Adjuvants function by protecting antigens from rapid degradation or dispersal. The effectiveness of experimental adjuvants can be assessed by measuring antibody titers to the antigen of interest or, less frequently, by evaluating the retention and distribution of antigen at the application site. In...

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Veröffentlicht in:	Pharmaceutical development and technology 2001, Vol.6 (2), p.241-246
Hauptverfasser:	MacLean, Donald S., Robertson, J. David, Jay, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Alum Compounds - administration & dosage Analysis Animals Antigens - administration & dosage Antigens - metabolism Biological and medical sciences Chemistry, Pharmaceutical Female Freund's Adjuvant - administration & dosage General pharmacology Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poloxamer - administration & dosage Protein Rats Rats, Sprague-Dawley Retention Spectrometry, X-Ray Emission X-ray Fluorescence (XRF)
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