The Influence of β-Glucan on Immune Responses in Broiler Chicks
Abstract Beta-1,3 1,6-glucan (β-glucan) was tested as a possible immunomodulator. Chicken macrophages from a macrophage cell line MQ-NCSU and from abdominal exudate of broiler chickens were exposed to various concentrations of β-glucan in vitro. In addition, day-old broiler chicks were fed a diet co...
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| Veröffentlicht in: | Immunopharmacology and immunotoxicology 2003-01, Vol.25 (3), p.461-472 |
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| creator | Guo, Yuming Ali, R. A. Qureshi, M. A. |
| description | Abstract
Beta-1,3 1,6-glucan (β-glucan) was tested as a possible immunomodulator. Chicken macrophages from a macrophage cell line MQ-NCSU and from abdominal exudate of broiler chickens were exposed to various concentrations of β-glucan in vitro. In addition, day-old broiler chicks were fed a diet containing 0, 20, and 40 mg kg β-glucan in the starter and 0, 20, and 20 mg kg in the grower diet. Several baseline immune parameters were examined following such exposures. The results showed that β-glucan exposure increased nitrite and interleukin-1 (IL-1) production as well as induced macrophage to proliferate in culture. However, IL-6 production was not affected. Dietary β-glucan supplementation increased the macrophage phagocytic activity, anti-sheep red blood cells antibody response post-boost, as well as the PHA-P-mediated lymphoproliferative response measured as a toe-web swelling. The percentage of CD4+, CD8+, and CD4+ CD8+ double positive lymphocytes in the intestinal intraepithelial leukocytes was increased in β-glucan supplemented chicks. Furthermore, the primary and secondary lymphoid organs such as bursa of Fabricius, thymus and spleen were larger in β-glucan-supplemented chicks as compared to the chicks on basal diet. The findings of these studies which showed that β-glucan improves several base-line immune responses in the chicken imply that β-glucan can be used as a possible immunomodulator in food animals such as the chicken. |
| doi_str_mv | 10.1081/IPH-120024513 |
| format | Article |
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Beta-1,3 1,6-glucan (β-glucan) was tested as a possible immunomodulator. Chicken macrophages from a macrophage cell line MQ-NCSU and from abdominal exudate of broiler chickens were exposed to various concentrations of β-glucan in vitro. In addition, day-old broiler chicks were fed a diet containing 0, 20, and 40 mg kg β-glucan in the starter and 0, 20, and 20 mg kg in the grower diet. Several baseline immune parameters were examined following such exposures. The results showed that β-glucan exposure increased nitrite and interleukin-1 (IL-1) production as well as induced macrophage to proliferate in culture. However, IL-6 production was not affected. Dietary β-glucan supplementation increased the macrophage phagocytic activity, anti-sheep red blood cells antibody response post-boost, as well as the PHA-P-mediated lymphoproliferative response measured as a toe-web swelling. The percentage of CD4+, CD8+, and CD4+ CD8+ double positive lymphocytes in the intestinal intraepithelial leukocytes was increased in β-glucan supplemented chicks. Furthermore, the primary and secondary lymphoid organs such as bursa of Fabricius, thymus and spleen were larger in β-glucan-supplemented chicks as compared to the chicks on basal diet. The findings of these studies which showed that β-glucan improves several base-line immune responses in the chicken imply that β-glucan can be used as a possible immunomodulator in food animals such as the chicken.</description><identifier>ISSN: 0892-3973</identifier><identifier>EISSN: 1532-2513</identifier><identifier>DOI: 10.1081/IPH-120024513</identifier><identifier>PMID: 19180808</identifier><identifier>CODEN: IITOEF</identifier><language>eng</language><publisher>Monticello, NY: Informa UK Ltd</publisher><subject>Animal Feed ; Animal Nutritional Physiological Phenomena ; Animals ; Animals, Newborn ; Antibodies - blood ; Antibody Formation - drug effects ; beta-Glucans - isolation & purification ; beta-Glucans - pharmacology ; Biological and medical sciences ; Cell Line ; Cell Proliferation - drug effects ; Chicken ; Chickens ; Dietary Supplements ; Dose-Response Relationship, Drug ; Immune functions ; Immunity, Cellular - drug effects ; Immunologic Factors - isolation & purification ; Immunologic Factors - pharmacology ; Immunomodulators ; Interleukin-1 - metabolism ; Intestines - drug effects ; Intestines - immunology ; Leukocytes - drug effects ; Leukocytes - immunology ; Lymphoid Tissue - drug effects ; Lymphoid Tissue - immunology ; Macrophages - drug effects ; Macrophages - immunology ; Medical sciences ; Nitrites - metabolism ; Phagocytosis - drug effects ; Pharmacology. Drug treatments ; Saccharomyces cerevisiae - chemistry ; β-glucan</subject><ispartof>Immunopharmacology and immunotoxicology, 2003-01, Vol.25 (3), p.461-472</ispartof><rights>2003 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-72e3ecaf2c6f40b453bb6547bf54fa396c33a788548af6944547c6a626a908683</citedby><cites>FETCH-LOGICAL-c491t-72e3ecaf2c6f40b453bb6547bf54fa396c33a788548af6944547c6a626a908683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1081/IPH-120024513$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1081/IPH-120024513$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15128435$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19180808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Yuming</creatorcontrib><creatorcontrib>Ali, R. A.</creatorcontrib><creatorcontrib>Qureshi, M. A.</creatorcontrib><title>The Influence of β-Glucan on Immune Responses in Broiler Chicks</title><title>Immunopharmacology and immunotoxicology</title><addtitle>Immunopharmacol Immunotoxicol</addtitle><description>Abstract
Beta-1,3 1,6-glucan (β-glucan) was tested as a possible immunomodulator. Chicken macrophages from a macrophage cell line MQ-NCSU and from abdominal exudate of broiler chickens were exposed to various concentrations of β-glucan in vitro. In addition, day-old broiler chicks were fed a diet containing 0, 20, and 40 mg kg β-glucan in the starter and 0, 20, and 20 mg kg in the grower diet. Several baseline immune parameters were examined following such exposures. The results showed that β-glucan exposure increased nitrite and interleukin-1 (IL-1) production as well as induced macrophage to proliferate in culture. However, IL-6 production was not affected. Dietary β-glucan supplementation increased the macrophage phagocytic activity, anti-sheep red blood cells antibody response post-boost, as well as the PHA-P-mediated lymphoproliferative response measured as a toe-web swelling. The percentage of CD4+, CD8+, and CD4+ CD8+ double positive lymphocytes in the intestinal intraepithelial leukocytes was increased in β-glucan supplemented chicks. Furthermore, the primary and secondary lymphoid organs such as bursa of Fabricius, thymus and spleen were larger in β-glucan-supplemented chicks as compared to the chicks on basal diet. The findings of these studies which showed that β-glucan improves several base-line immune responses in the chicken imply that β-glucan can be used as a possible immunomodulator in food animals such as the chicken.</description><subject>Animal Feed</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antibodies - blood</subject><subject>Antibody Formation - drug effects</subject><subject>beta-Glucans - isolation & purification</subject><subject>beta-Glucans - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell Proliferation - drug effects</subject><subject>Chicken</subject><subject>Chickens</subject><subject>Dietary Supplements</subject><subject>Dose-Response Relationship, Drug</subject><subject>Immune functions</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunologic Factors - isolation & purification</subject><subject>Immunologic Factors - pharmacology</subject><subject>Immunomodulators</subject><subject>Interleukin-1 - metabolism</subject><subject>Intestines - drug effects</subject><subject>Intestines - immunology</subject><subject>Leukocytes - drug effects</subject><subject>Leukocytes - immunology</subject><subject>Lymphoid Tissue - drug effects</subject><subject>Lymphoid Tissue - immunology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - immunology</subject><subject>Medical sciences</subject><subject>Nitrites - metabolism</subject><subject>Phagocytosis - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Saccharomyces cerevisiae - chemistry</subject><subject>β-glucan</subject><issn>0892-3973</issn><issn>1532-2513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9qVDEUh4Modtq6dCvZ6O5q_t9k1zrYdqCglLoOuekJc2tuMiZzkb5WH8RnaspMLS7KWZwD5zuHHx9C7yn5TImmX1Y_LjrKCGFCUv4KLajkrGNtfo0WRBvWcdPzA3RY6y0h1PREvkUH1FBNWi3QyfUa8CqFOEPygHPAf--78zh7l3BOeDVNcwJ8BXWTU4WKx4S_ljxGKHi5Hv2veozeBBcrvNv3I_Tz7Nv18qK7_H6-Wp5edl4Yuu16Bhy8C8yrIMggJB8GJUU_BCmC40Z5zl2vtRTaBWWEaDuvnGLKGaKV5kfo0-7vpuTfM9StncbqIUaXIM_VUsM4V5o1sNuBvuRaCwS7KePkyp2lxD4qs02Z_aes8R_2j-dhgptneu-oAR_3gKvexVBc8mN95iRlWnDZOL3jxhRymdyfXOKN3bq7mMvTEX8pQ__f6Rpc3K69K2Bv81xSE_tC-ge5dZZn</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Guo, Yuming</creator><creator>Ali, R. A.</creator><creator>Qureshi, M. A.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20030101</creationdate><title>The Influence of β-Glucan on Immune Responses in Broiler Chicks</title><author>Guo, Yuming ; Ali, R. A. ; Qureshi, M. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-72e3ecaf2c6f40b453bb6547bf54fa396c33a788548af6944547c6a626a908683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animal Feed</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antibodies - blood</topic><topic>Antibody Formation - drug effects</topic><topic>beta-Glucans - isolation & purification</topic><topic>beta-Glucans - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cell Proliferation - drug effects</topic><topic>Chicken</topic><topic>Chickens</topic><topic>Dietary Supplements</topic><topic>Dose-Response Relationship, Drug</topic><topic>Immune functions</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunologic Factors - isolation & purification</topic><topic>Immunologic Factors - pharmacology</topic><topic>Immunomodulators</topic><topic>Interleukin-1 - metabolism</topic><topic>Intestines - drug effects</topic><topic>Intestines - immunology</topic><topic>Leukocytes - drug effects</topic><topic>Leukocytes - immunology</topic><topic>Lymphoid Tissue - drug effects</topic><topic>Lymphoid Tissue - immunology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - immunology</topic><topic>Medical sciences</topic><topic>Nitrites - metabolism</topic><topic>Phagocytosis - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Saccharomyces cerevisiae - chemistry</topic><topic>β-glucan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Yuming</creatorcontrib><creatorcontrib>Ali, R. A.</creatorcontrib><creatorcontrib>Qureshi, M. A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Immunopharmacology and immunotoxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Yuming</au><au>Ali, R. A.</au><au>Qureshi, M. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Influence of β-Glucan on Immune Responses in Broiler Chicks</atitle><jtitle>Immunopharmacology and immunotoxicology</jtitle><addtitle>Immunopharmacol Immunotoxicol</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>25</volume><issue>3</issue><spage>461</spage><epage>472</epage><pages>461-472</pages><issn>0892-3973</issn><eissn>1532-2513</eissn><coden>IITOEF</coden><abstract>Abstract
Beta-1,3 1,6-glucan (β-glucan) was tested as a possible immunomodulator. Chicken macrophages from a macrophage cell line MQ-NCSU and from abdominal exudate of broiler chickens were exposed to various concentrations of β-glucan in vitro. In addition, day-old broiler chicks were fed a diet containing 0, 20, and 40 mg kg β-glucan in the starter and 0, 20, and 20 mg kg in the grower diet. Several baseline immune parameters were examined following such exposures. The results showed that β-glucan exposure increased nitrite and interleukin-1 (IL-1) production as well as induced macrophage to proliferate in culture. However, IL-6 production was not affected. Dietary β-glucan supplementation increased the macrophage phagocytic activity, anti-sheep red blood cells antibody response post-boost, as well as the PHA-P-mediated lymphoproliferative response measured as a toe-web swelling. The percentage of CD4+, CD8+, and CD4+ CD8+ double positive lymphocytes in the intestinal intraepithelial leukocytes was increased in β-glucan supplemented chicks. Furthermore, the primary and secondary lymphoid organs such as bursa of Fabricius, thymus and spleen were larger in β-glucan-supplemented chicks as compared to the chicks on basal diet. The findings of these studies which showed that β-glucan improves several base-line immune responses in the chicken imply that β-glucan can be used as a possible immunomodulator in food animals such as the chicken.</abstract><cop>Monticello, NY</cop><pub>Informa UK Ltd</pub><pmid>19180808</pmid><doi>10.1081/IPH-120024513</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0892-3973 |
| ispartof | Immunopharmacology and immunotoxicology, 2003-01, Vol.25 (3), p.461-472 |
| issn | 0892-3973 1532-2513 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animal Feed Animal Nutritional Physiological Phenomena Animals Animals, Newborn Antibodies - blood Antibody Formation - drug effects beta-Glucans - isolation & purification beta-Glucans - pharmacology Biological and medical sciences Cell Line Cell Proliferation - drug effects Chicken Chickens Dietary Supplements Dose-Response Relationship, Drug Immune functions Immunity, Cellular - drug effects Immunologic Factors - isolation & purification Immunologic Factors - pharmacology Immunomodulators Interleukin-1 - metabolism Intestines - drug effects Intestines - immunology Leukocytes - drug effects Leukocytes - immunology Lymphoid Tissue - drug effects Lymphoid Tissue - immunology Macrophages - drug effects Macrophages - immunology Medical sciences Nitrites - metabolism Phagocytosis - drug effects Pharmacology. Drug treatments Saccharomyces cerevisiae - chemistry β-glucan |
| title | The Influence of β-Glucan on Immune Responses in Broiler Chicks |
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