Evaluation of Eudragit® RS-PO and Ethocel® 100 Matrices for the Controlled Release of Lobenzarit Disodium
Lobenzarit disodium is a drug for the treatment of rheumatoid arthritis. In this work, inert matrix tablets of lobenzarit disodium were prepared by direct compression using Ethocel® 100 and Eudragit® RS-PO as polymeric materials in different ratios. The obtained powder mixtures and tablets were eval...
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| Veröffentlicht in: | Drug development and industrial pharmacy 1999-01, Vol.25 (2), p.229-233 |
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| container_title | Drug development and industrial pharmacy |
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| creator | Boza, A. Caraballo, I. Alvarez-Fuentes, J. Rabasco, A. M. |
| description | Lobenzarit disodium is a drug for the treatment of rheumatoid arthritis. In this work, inert matrix tablets of lobenzarit disodium were prepared by direct compression using Ethocel® 100 and Eudragit® RS-PO as polymeric materials in different ratios. The obtained powder mixtures and tablets were evaluated from the rheological and technological points of view. The dissolution test was performed to evaluate the in vitro release kinetic of the matrices. The obtained dissolution profiles demonstrated that the matrices containing Eudragit RS-PO showed a slower release rate and therefore were more suitable for controlling the release of drug. The fit to the Higuchi model indicates that the drug release mechanism from these matrices was controlled by the diffusion step. |
| doi_str_mv | 10.1081/DDC-100102164 |
| format | Article |
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M.</creator><creatorcontrib>Boza, A. ; Caraballo, I. ; Alvarez-Fuentes, J. ; Rabasco, A. M.</creatorcontrib><description>Lobenzarit disodium is a drug for the treatment of rheumatoid arthritis. In this work, inert matrix tablets of lobenzarit disodium were prepared by direct compression using Ethocel® 100 and Eudragit® RS-PO as polymeric materials in different ratios. The obtained powder mixtures and tablets were evaluated from the rheological and technological points of view. The dissolution test was performed to evaluate the in vitro release kinetic of the matrices. The obtained dissolution profiles demonstrated that the matrices containing Eudragit RS-PO showed a slower release rate and therefore were more suitable for controlling the release of drug. The fit to the Higuchi model indicates that the drug release mechanism from these matrices was controlled by the diffusion step.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.1081/DDC-100102164</identifier><identifier>PMID: 10065357</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Acrylic Resins ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Cellulose - analogs & derivatives ; Chemistry, Pharmaceutical ; Delayed-Action Preparations ; Drug Delivery Systems ; Excipients ; General pharmacology ; Medical sciences ; ortho-Aminobenzoates - administration & dosage ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polymers ; Polymethacrylic Acids ; Powders ; Rheology ; Tablets</subject><ispartof>Drug development and industrial pharmacy, 1999-01, Vol.25 (2), p.229-233</ispartof><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-9130281bb23c31a84ff915cf656acd7efaa07005b6fc2ffcad6e65d7412f24b63</citedby><cites>FETCH-LOGICAL-c415t-9130281bb23c31a84ff915cf656acd7efaa07005b6fc2ffcad6e65d7412f24b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1081/DDC-100102164$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1081/DDC-100102164$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1685563$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10065357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boza, A.</creatorcontrib><creatorcontrib>Caraballo, I.</creatorcontrib><creatorcontrib>Alvarez-Fuentes, J.</creatorcontrib><creatorcontrib>Rabasco, A. M.</creatorcontrib><title>Evaluation of Eudragit® RS-PO and Ethocel® 100 Matrices for the Controlled Release of Lobenzarit Disodium</title><title>Drug development and industrial pharmacy</title><addtitle>Drug Dev Ind Pharm</addtitle><description>Lobenzarit disodium is a drug for the treatment of rheumatoid arthritis. In this work, inert matrix tablets of lobenzarit disodium were prepared by direct compression using Ethocel® 100 and Eudragit® RS-PO as polymeric materials in different ratios. The obtained powder mixtures and tablets were evaluated from the rheological and technological points of view. The dissolution test was performed to evaluate the in vitro release kinetic of the matrices. The obtained dissolution profiles demonstrated that the matrices containing Eudragit RS-PO showed a slower release rate and therefore were more suitable for controlling the release of drug. The fit to the Higuchi model indicates that the drug release mechanism from these matrices was controlled by the diffusion step.</description><subject>Acrylic Resins</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Cellulose - analogs & derivatives</subject><subject>Chemistry, Pharmaceutical</subject><subject>Delayed-Action Preparations</subject><subject>Drug Delivery Systems</subject><subject>Excipients</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>ortho-Aminobenzoates - administration & dosage</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymers</subject><subject>Polymethacrylic Acids</subject><subject>Powders</subject><subject>Rheology</subject><subject>Tablets</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtu1DAUhi0EokNhyRZ5gboL9SV2kiWamVKkQUUF1tGJL4yLExfbAbUP1Yfok-HRDLdFV0c6-v5f53wIvaTkDSUtPV2tlhUlhBJGZf0ILahgpBKNZI_RgnDJq47U4gg9S-mqUKwT4ik6KgEpuGgW6Nv6B_gZsgsTDhavZx3hq8v3d_jyU_XxAsOk8TpvgzK-7EoOf4AcnTIJ2xBx3hq8DFOOwXuj8aXxBpLZNW3CYKZbiC7jlUtBu3l8jp5Y8Mm8OMxj9OVs_Xl5Xm0u3r1fvt1UqqYiVx3lhLV0GBhXnEJbW9tRoawUEpRujAUgDSFikFYxaxVoaaTQTU2ZZfUg-TE62fdex_B9Nin3o0vlAQ-TCXPqZSeJlGwHVntQxZBSNLa_jm6EeNNT0u_s9sVu_8du4V8diudhNPofeq-zAK8PACQF3kaYlEt_OdkKIXnB2j3mpiJxhJ8het1nuPEh_s7wh05o_otuDfi8VRBNfxXmOBWvDxz_Cx1hpqo</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Boza, A.</creator><creator>Caraballo, I.</creator><creator>Alvarez-Fuentes, J.</creator><creator>Rabasco, A. 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Antiinflammatory agents</topic><topic>Cellulose - analogs & derivatives</topic><topic>Chemistry, Pharmaceutical</topic><topic>Delayed-Action Preparations</topic><topic>Drug Delivery Systems</topic><topic>Excipients</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>ortho-Aminobenzoates - administration & dosage</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymers</topic><topic>Polymethacrylic Acids</topic><topic>Powders</topic><topic>Rheology</topic><topic>Tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boza, A.</creatorcontrib><creatorcontrib>Caraballo, I.</creatorcontrib><creatorcontrib>Alvarez-Fuentes, J.</creatorcontrib><creatorcontrib>Rabasco, A. M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug development and industrial pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boza, A.</au><au>Caraballo, I.</au><au>Alvarez-Fuentes, J.</au><au>Rabasco, A. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Eudragit® RS-PO and Ethocel® 100 Matrices for the Controlled Release of Lobenzarit Disodium</atitle><jtitle>Drug development and industrial pharmacy</jtitle><addtitle>Drug Dev Ind Pharm</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>25</volume><issue>2</issue><spage>229</spage><epage>233</epage><pages>229-233</pages><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>Lobenzarit disodium is a drug for the treatment of rheumatoid arthritis. In this work, inert matrix tablets of lobenzarit disodium were prepared by direct compression using Ethocel® 100 and Eudragit® RS-PO as polymeric materials in different ratios. The obtained powder mixtures and tablets were evaluated from the rheological and technological points of view. The dissolution test was performed to evaluate the in vitro release kinetic of the matrices. The obtained dissolution profiles demonstrated that the matrices containing Eudragit RS-PO showed a slower release rate and therefore were more suitable for controlling the release of drug. The fit to the Higuchi model indicates that the drug release mechanism from these matrices was controlled by the diffusion step.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>10065357</pmid><doi>10.1081/DDC-100102164</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-9045 |
| ispartof | Drug development and industrial pharmacy, 1999-01, Vol.25 (2), p.229-233 |
| issn | 0363-9045 1520-5762 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_1081_DDC_100102164 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete; EBSCOhost Business Source Complete |
| subjects | Acrylic Resins Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cellulose - analogs & derivatives Chemistry, Pharmaceutical Delayed-Action Preparations Drug Delivery Systems Excipients General pharmacology Medical sciences ortho-Aminobenzoates - administration & dosage Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymers Polymethacrylic Acids Powders Rheology Tablets |
| title | Evaluation of Eudragit® RS-PO and Ethocel® 100 Matrices for the Controlled Release of Lobenzarit Disodium |
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