Silica-Induced TNF-α and TGF-β1 Expression in RAW264.7 Cells are Dependent on Src-ERK/AP-1 Pathways

The cytokines secreted by lung macrophages have been shown to play a critical role in the pathogenesis of silicosis, tumor necrosis factor-α (TNF-α), and transforming growth factor-β1 (TGF-β1) are prominent cytokines in silicosis, but the underlying mechanism remains to be determined. The aim of the...

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Veröffentlicht in:	Toxicology mechanisms and methods 2009, Vol.19 (1), p.51-58
Hauptverfasser:	Li, Xiang, Hu, Yongbin, Jin, Zhongyuan, Jiang, Haiying, Wen, Jifang
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein-1 Mitogen-activated protein kinase Silica Src tyrosine kinases Transforming growth factor-β1 Tumor necrosis factor-α
Online-Zugang:	Volltext
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