Calpain inhibitory flavonoids isolated from Orostachys japonicus

The n-butanol (n-BuOH) fraction of Orostachys japonicus A. Berger (Crassulaceae) significantly inhibited calpain activity. Through the activity-guided isolation from the n-BuOH fraction, herbacetin 8-O-α-D-ribopyranoside (1), kaempferol (2), quercetin (3), afzelin (4), astragalin (5), isoquercetin (...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2009-06, Vol.24 (3), p.676-679
Hauptverfasser:	Je Ma, Choong, Jung, Won Joo, Lee, Ki Yong, Kim, Young Choong, Sung, Sang Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Butanol - chemistry calpain Calpain - antagonists & inhibitors Calpain - metabolism Crassulaceae Crassulaceae - chemistry Cysteine Proteinase Inhibitors - chemistry Cysteine Proteinase Inhibitors - isolation & purification Cysteine Proteinase Inhibitors - pharmacology flavonoid Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology inhibition Kaempferols - chemistry Kaempferols - isolation & purification Kaempferols - pharmacology Magnetic Resonance Spectroscopy Molecular Structure neuroprotection Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology Orostachys japonicus Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Quercetin - chemistry Quercetin - isolation & purification Quercetin - pharmacology
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