Inhibition of Naja Nigricolis Venom Acidic Phospholipase A 2 Catalysed Hydrolysis of Ghost Red Blood Cells by Columbin

The inhibitory effects of a naturally occurring diterpenoid furanolactone, columbin, on partially purified acidic phospholipase A 2 (PLA 2) from Naja nigricolis was investigated. Columbin inhibited the N. nigricolis PLA 2 in a dose related pattern with an IC 50 value of 2.5 μM. Double reciprocal plo...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2002, Vol.17 (1), p.55-60
Hauptverfasser:	Nok, A.J., Balogun, E., Lori, J.A., Abubakar, M.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Columbin Inhibition Naja Nigricolis Pla 2
Online-Zugang:	Volltext
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