Cardiovascular reflexes during treatment of social phobia with moclobemide
INTRODUCTION: Cardiovascular side-effects are less frequent with moclobemide than with tricyclic or monoamine oxidase inhibitor antidepressants. We performed a detailed assessment of cardiovascular reflexes in 15 patients meeting DSM-III-R criteria for social phobia, before treatment and whilst taki...
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| Veröffentlicht in: | International journal of psychiatry in clinical practice 2001, Vol.5 (1), p.27-31 |
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| container_title | International journal of psychiatry in clinical practice |
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| creator | J Coupland, Caroline Bell, John P Potokar, Jayne E Bailey, David J Nutt, Nick |
| description | INTRODUCTION: Cardiovascular side-effects are less frequent with moclobemide than with tricyclic or monoamine oxidase inhibitor antidepressants. We performed a detailed assessment of cardiovascular reflexes in 15 patients meeting DSM-III-R criteria for social phobia, before treatment and whilst taking a stable dose of moclobemide for a median of 7 weeks. METHOD: Cardiovascular reflex responses to standing, deep breathing and the Valsalva manoeuvre were assessed using beat-by-beat blood pressure and heart rate recording. RESULTS: Moclobemide produced a statistically significant, but clinically modest, degree of improvement in social phobia symptoms. Only the maximum change in heart rate from supine to standing showed a change from before to after treatment, which was not statistically significant after Bonferroni correction, and there was no consistent pattern of altered sympathetic or parasympathetic function. CONCLUSION: Moclobemide is relatively devoid of cardiovascular autonomic effects in physically healthy subjects with social phobia. ( Int J Psych Clin Pract 2001; 5:27-31) |
| doi_str_mv | 10.1080/136515001300225169 |
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We performed a detailed assessment of cardiovascular reflexes in 15 patients meeting DSM-III-R criteria for social phobia, before treatment and whilst taking a stable dose of moclobemide for a median of 7 weeks. METHOD: Cardiovascular reflex responses to standing, deep breathing and the Valsalva manoeuvre were assessed using beat-by-beat blood pressure and heart rate recording. RESULTS: Moclobemide produced a statistically significant, but clinically modest, degree of improvement in social phobia symptoms. Only the maximum change in heart rate from supine to standing showed a change from before to after treatment, which was not statistically significant after Bonferroni correction, and there was no consistent pattern of altered sympathetic or parasympathetic function. CONCLUSION: Moclobemide is relatively devoid of cardiovascular autonomic effects in physically healthy subjects with social phobia. 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We performed a detailed assessment of cardiovascular reflexes in 15 patients meeting DSM-III-R criteria for social phobia, before treatment and whilst taking a stable dose of moclobemide for a median of 7 weeks. METHOD: Cardiovascular reflex responses to standing, deep breathing and the Valsalva manoeuvre were assessed using beat-by-beat blood pressure and heart rate recording. RESULTS: Moclobemide produced a statistically significant, but clinically modest, degree of improvement in social phobia symptoms. Only the maximum change in heart rate from supine to standing showed a change from before to after treatment, which was not statistically significant after Bonferroni correction, and there was no consistent pattern of altered sympathetic or parasympathetic function. CONCLUSION: Moclobemide is relatively devoid of cardiovascular autonomic effects in physically healthy subjects with social phobia. 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| ispartof | International journal of psychiatry in clinical practice, 2001, Vol.5 (1), p.27-31 |
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| source | Taylor & Francis; Taylor & Francis Medical Library - CRKN |
| subjects | Social Phobia Autonomic Nervous System Antidepressant Monoamine Oxidase Inhibitor Blood Pressure Monitoring |
| title | Cardiovascular reflexes during treatment of social phobia with moclobemide |
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