Preparation of honokiol-loaded chitosan microparticles via spray-drying method intended for pulmonary delivery
It has been demonstrated that spray-drying is a powerful method to prepare dry powders for pulmonary delivery. This paper prepared dispersible dry powders based on chitosan and mannitol containing honokiol nanoparticles as model drug. The results showed that the prepared microparticles are almost sp...
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| Veröffentlicht in: | Drug delivery 2009-04, Vol.16 (3), p.160-166 |
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| container_title | Drug delivery |
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| creator | Li, XingYi Guo, QingFa Zheng, XiuLing Kong, XiangYe Shi, Shuai Chen, Lijuan Zhao, Xia Wei, YuQuan Qian, ZhiYong |
| description | It has been demonstrated that spray-drying is a powerful method to prepare dry powders for pulmonary delivery. This paper prepared dispersible dry powders based on chitosan and mannitol containing honokiol nanoparticles as model drug. The results showed that the prepared microparticles are almost spherical and have appropriate aerodynamic properties for pulmonary delivery (aerodynamic diameters was between 2.8-3.3 μm and tapped density ranging from 0.14-0. 18 g/cm3). Moreover, surface morphology and aerodynamic properties of the powders were strongly affected by the content of mannitol. Fourier transform infra-red (FTIR) spectrum of powders indicated that the honokiol nanoparticles were successfully incorporated into microparticles. In vitro drug release profile was also observed. The content of mannitol in powders significantly influenced the release rate of honokiol from matrices. |
| doi_str_mv | 10.1080/10717540902738341 |
| format | Article |
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This paper prepared dispersible dry powders based on chitosan and mannitol containing honokiol nanoparticles as model drug. The results showed that the prepared microparticles are almost spherical and have appropriate aerodynamic properties for pulmonary delivery (aerodynamic diameters was between 2.8-3.3 μm and tapped density ranging from 0.14-0. 18 g/cm3). Moreover, surface morphology and aerodynamic properties of the powders were strongly affected by the content of mannitol. Fourier transform infra-red (FTIR) spectrum of powders indicated that the honokiol nanoparticles were successfully incorporated into microparticles. In vitro drug release profile was also observed. The content of mannitol in powders significantly influenced the release rate of honokiol from matrices.</description><identifier>ISSN: 1071-7544</identifier><identifier>EISSN: 1521-0464</identifier><identifier>DOI: 10.1080/10717540902738341</identifier><identifier>PMID: 19514976</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Administration, Inhalation ; Administration, Intranasal ; Biphenyl Compounds - administration & dosage ; Chemistry, Pharmaceutical ; chitosan ; Chitosan - chemistry ; Drug Carriers - administration & dosage ; Drug Carriers - chemistry ; Drug Compounding ; Drug Delivery Systems ; Drug Stability ; Excipients - administration & dosage ; Honokiol nanoparticles ; in vitro release ; Lignans - administration & dosage ; Lung - metabolism ; Mannitol - chemistry ; Nanoparticles - chemistry ; Powders - chemistry ; Respiratory Mucosa - metabolism ; spray-drying ; Technology, Pharmaceutical</subject><ispartof>Drug delivery, 2009-04, Vol.16 (3), p.160-166</ispartof><rights>2009 Informa UK Ltd 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-fc199614d5660dc746f87197c804bfd01baf39c91110ea12bb619eab556155233</citedby><cites>FETCH-LOGICAL-c435t-fc199614d5660dc746f87197c804bfd01baf39c91110ea12bb619eab556155233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10717540902738341$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10717540902738341$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19514976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, XingYi</creatorcontrib><creatorcontrib>Guo, QingFa</creatorcontrib><creatorcontrib>Zheng, XiuLing</creatorcontrib><creatorcontrib>Kong, XiangYe</creatorcontrib><creatorcontrib>Shi, Shuai</creatorcontrib><creatorcontrib>Chen, Lijuan</creatorcontrib><creatorcontrib>Zhao, Xia</creatorcontrib><creatorcontrib>Wei, YuQuan</creatorcontrib><creatorcontrib>Qian, ZhiYong</creatorcontrib><title>Preparation of honokiol-loaded chitosan microparticles via spray-drying method intended for pulmonary delivery</title><title>Drug delivery</title><addtitle>Drug Deliv</addtitle><description>It has been demonstrated that spray-drying is a powerful method to prepare dry powders for pulmonary delivery. This paper prepared dispersible dry powders based on chitosan and mannitol containing honokiol nanoparticles as model drug. The results showed that the prepared microparticles are almost spherical and have appropriate aerodynamic properties for pulmonary delivery (aerodynamic diameters was between 2.8-3.3 μm and tapped density ranging from 0.14-0. 18 g/cm3). Moreover, surface morphology and aerodynamic properties of the powders were strongly affected by the content of mannitol. Fourier transform infra-red (FTIR) spectrum of powders indicated that the honokiol nanoparticles were successfully incorporated into microparticles. In vitro drug release profile was also observed. The content of mannitol in powders significantly influenced the release rate of honokiol from matrices.</description><subject>Administration, Inhalation</subject><subject>Administration, Intranasal</subject><subject>Biphenyl Compounds - administration & dosage</subject><subject>Chemistry, Pharmaceutical</subject><subject>chitosan</subject><subject>Chitosan - chemistry</subject><subject>Drug Carriers - administration & dosage</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Compounding</subject><subject>Drug Delivery Systems</subject><subject>Drug Stability</subject><subject>Excipients - administration & dosage</subject><subject>Honokiol nanoparticles</subject><subject>in vitro release</subject><subject>Lignans - administration & dosage</subject><subject>Lung - metabolism</subject><subject>Mannitol - chemistry</subject><subject>Nanoparticles - chemistry</subject><subject>Powders - chemistry</subject><subject>Respiratory Mucosa - metabolism</subject><subject>spray-drying</subject><subject>Technology, Pharmaceutical</subject><issn>1071-7544</issn><issn>1521-0464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFzEQxoMotlY_gBfJydvqzG6yL-hFim9QqId6XrJ5cVOzyZpkW_bbN-X_BxGhPc3A_J6HmWcIeY3wDqGH9wgddpzBAHXX9A3DJ-QUeY0VsJY9LX2ZVwVgJ-RFStcA0GPNn5MTHDiyoWtPif8R9SqiyDZ4Ggydgw-_bXCVC0JpReVsc0jC08XKGAqZrXQ60RsraFqj2CsVd-t_0UXnOShqfdb-XmhCpOvmluBF3KnSzt7ouL8kz4xwSb861jPy88vnq_Nv1cXl1-_nny4qyRqeKyNxGFpkirctKNmx1vQdDp3sgU1GAU7CNIMcEBG0wHqaWhy0mDhvkfO6ac7I24PvGsOfTac8LjZJ7ZzwOmxpbLuGNzXgo2ANUBbBroB4AEsMKUVtxjXapdw2Ioz33xj_-0bRvDmab9Oi1V_FMf4CfDwA1pe8FnEbolNjFrsL0UThpU1j85D_h3_ksxYuz1JEPV6HLfqS8APb3QEgcKun</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Li, XingYi</creator><creator>Guo, QingFa</creator><creator>Zheng, XiuLing</creator><creator>Kong, XiangYe</creator><creator>Shi, Shuai</creator><creator>Chen, Lijuan</creator><creator>Zhao, Xia</creator><creator>Wei, YuQuan</creator><creator>Qian, ZhiYong</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Preparation of honokiol-loaded chitosan microparticles via spray-drying method intended for pulmonary delivery</title><author>Li, XingYi ; Guo, QingFa ; Zheng, XiuLing ; Kong, XiangYe ; Shi, Shuai ; Chen, Lijuan ; Zhao, Xia ; Wei, YuQuan ; Qian, ZhiYong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-fc199614d5660dc746f87197c804bfd01baf39c91110ea12bb619eab556155233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Administration, Inhalation</topic><topic>Administration, Intranasal</topic><topic>Biphenyl Compounds - administration & dosage</topic><topic>Chemistry, Pharmaceutical</topic><topic>chitosan</topic><topic>Chitosan - chemistry</topic><topic>Drug Carriers - administration & dosage</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Compounding</topic><topic>Drug Delivery Systems</topic><topic>Drug Stability</topic><topic>Excipients - administration & dosage</topic><topic>Honokiol nanoparticles</topic><topic>in vitro release</topic><topic>Lignans - administration & dosage</topic><topic>Lung - metabolism</topic><topic>Mannitol - chemistry</topic><topic>Nanoparticles - chemistry</topic><topic>Powders - chemistry</topic><topic>Respiratory Mucosa - metabolism</topic><topic>spray-drying</topic><topic>Technology, Pharmaceutical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, XingYi</creatorcontrib><creatorcontrib>Guo, QingFa</creatorcontrib><creatorcontrib>Zheng, XiuLing</creatorcontrib><creatorcontrib>Kong, XiangYe</creatorcontrib><creatorcontrib>Shi, Shuai</creatorcontrib><creatorcontrib>Chen, Lijuan</creatorcontrib><creatorcontrib>Zhao, Xia</creatorcontrib><creatorcontrib>Wei, YuQuan</creatorcontrib><creatorcontrib>Qian, ZhiYong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Drug delivery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, XingYi</au><au>Guo, QingFa</au><au>Zheng, XiuLing</au><au>Kong, XiangYe</au><au>Shi, Shuai</au><au>Chen, Lijuan</au><au>Zhao, Xia</au><au>Wei, YuQuan</au><au>Qian, ZhiYong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of honokiol-loaded chitosan microparticles via spray-drying method intended for pulmonary delivery</atitle><jtitle>Drug delivery</jtitle><addtitle>Drug Deliv</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>16</volume><issue>3</issue><spage>160</spage><epage>166</epage><pages>160-166</pages><issn>1071-7544</issn><eissn>1521-0464</eissn><abstract>It has been demonstrated that spray-drying is a powerful method to prepare dry powders for pulmonary delivery. This paper prepared dispersible dry powders based on chitosan and mannitol containing honokiol nanoparticles as model drug. The results showed that the prepared microparticles are almost spherical and have appropriate aerodynamic properties for pulmonary delivery (aerodynamic diameters was between 2.8-3.3 μm and tapped density ranging from 0.14-0. 18 g/cm3). Moreover, surface morphology and aerodynamic properties of the powders were strongly affected by the content of mannitol. Fourier transform infra-red (FTIR) spectrum of powders indicated that the honokiol nanoparticles were successfully incorporated into microparticles. In vitro drug release profile was also observed. The content of mannitol in powders significantly influenced the release rate of honokiol from matrices.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>19514976</pmid><doi>10.1080/10717540902738341</doi><tpages>7</tpages></addata></record> |
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| ispartof | Drug delivery, 2009-04, Vol.16 (3), p.160-166 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Taylor & Francis Journals Complete |
| subjects | Administration, Inhalation Administration, Intranasal Biphenyl Compounds - administration & dosage Chemistry, Pharmaceutical chitosan Chitosan - chemistry Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Compounding Drug Delivery Systems Drug Stability Excipients - administration & dosage Honokiol nanoparticles in vitro release Lignans - administration & dosage Lung - metabolism Mannitol - chemistry Nanoparticles - chemistry Powders - chemistry Respiratory Mucosa - metabolism spray-drying Technology, Pharmaceutical |
| title | Preparation of honokiol-loaded chitosan microparticles via spray-drying method intended for pulmonary delivery |
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