A Cell-Based Drug Delivery System for Lung Targeting: I. Preparation and Pharmacokinetics

A drug-loaded tumor cell (DLTC) system has been developed for lung metastasis-targeting drug delivery. Doxorubicin was loaded into B16-F10 murine melanoma cells (96 microg/10(6) cells). The loading process led to the death of all the carrier cells. The diameter of DLTC was 15.03+/-2.36 microm (mean...

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Veröffentlicht in:	Drug delivery 2001-04, Vol.8 (2), p.61-69
1. Verfasser:	Jun Shao, Jean DeHaven, Donald Lamm, David N. Weissman, Kenneth Runyan, Carl J. Malanga, Yongyut Rojanasakul, Joseph K. H. Ma
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - therapeutic use Cell Adhesion Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Doxorubicin - therapeutic use Doxorubicin Lung-TARGETING Novel Drug Delivery System Pharmacokinetics Drug Delivery Systems Drug Stability Female Flow Cytometry Lung Neoplasms - drug therapy Melanoma, Experimental - drug therapy Mice Mice, Inbred C57BL Particle Size Tissue Distribution Trypsin - chemistry Tumor Cells, Cultured
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