Plasma 8-iso-prostaglandin F2α, a marker of oxidative stress, is increased in patients with acute myocardial infarction
Background: Oxidative stress has been implicated in the pathogenesis of atherogenesis. The aim of our study is to examine whether the plasma 8-iso-prostaglandin F2α level, a marker of oxidative stress, is elevated in patients with acute myocardial infarction. Methods: Three groups of patients were e...
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| Veröffentlicht in: | Free radical research 2006-01, Vol.40 (4), p.385-391 |
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| creator | Elesber, Ahmad A. Best, Patricia J. Lennon, Ryan J. Mathew, Verghese Rihal, Charanjit S. Lerman, Lilach O. Lerman, Amir |
| description | Background: Oxidative stress has been implicated in the pathogenesis of atherogenesis. The aim of our study is to examine whether the plasma 8-iso-prostaglandin F2α level, a marker of oxidative stress, is elevated in patients with acute myocardial infarction.
Methods: Three groups of patients were enrolled: (1) patients with no or minimal coronary artery disease (CAD) (n = 15); (2) patients with stable CAD (n = 31); (3) patients with acute myocardial infarction (n = 13).
Results: Plasma 8-iso-prostaglandin F2α levels were significantly elevated (p < 0.001) in patients with acute myocardial infarction (290.7 ± 73.9 pg/ml) as compared to patients with stable CAD (182.0+75.7 pg/ml) and patients with no significant CAD (118.9 ± 85.5 pg/ml). This remained significant after correcting for coronary atherosclerosis risk factors, age, extent of atherosclerosis, and C-reactive protein (CRP) level.
Conclusion: Plasma 8-iso-prostaglandin F2α levels are elevated in patients with acute myocardial infarction. Endogenous oxidative stress may contribute to the pathogenesis of atherosclerosis and its complications, namely myocardial infarction. |
| doi_str_mv | 10.1080/10715760500539154 |
| format | Article |
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Methods: Three groups of patients were enrolled: (1) patients with no or minimal coronary artery disease (CAD) (n = 15); (2) patients with stable CAD (n = 31); (3) patients with acute myocardial infarction (n = 13).
Results: Plasma 8-iso-prostaglandin F2α levels were significantly elevated (p < 0.001) in patients with acute myocardial infarction (290.7 ± 73.9 pg/ml) as compared to patients with stable CAD (182.0+75.7 pg/ml) and patients with no significant CAD (118.9 ± 85.5 pg/ml). This remained significant after correcting for coronary atherosclerosis risk factors, age, extent of atherosclerosis, and C-reactive protein (CRP) level.
Conclusion: Plasma 8-iso-prostaglandin F2α levels are elevated in patients with acute myocardial infarction. Endogenous oxidative stress may contribute to the pathogenesis of atherosclerosis and its complications, namely myocardial infarction.</description><identifier>ISSN: 1071-5762</identifier><identifier>EISSN: 1029-2470</identifier><identifier>DOI: 10.1080/10715760500539154</identifier><language>eng</language><publisher>Informa UK Ltd</publisher><subject>artherosclerosis ; isoprostanes ; myocardial infarction ; Oxidative stress</subject><ispartof>Free radical research, 2006-01, Vol.40 (4), p.385-391</ispartof><rights>2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10715760500539154$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10715760500539154$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409,61194,61375</link.rule.ids></links><search><creatorcontrib>Elesber, Ahmad A.</creatorcontrib><creatorcontrib>Best, Patricia J.</creatorcontrib><creatorcontrib>Lennon, Ryan J.</creatorcontrib><creatorcontrib>Mathew, Verghese</creatorcontrib><creatorcontrib>Rihal, Charanjit S.</creatorcontrib><creatorcontrib>Lerman, Lilach O.</creatorcontrib><creatorcontrib>Lerman, Amir</creatorcontrib><title>Plasma 8-iso-prostaglandin F2α, a marker of oxidative stress, is increased in patients with acute myocardial infarction</title><title>Free radical research</title><description>Background: Oxidative stress has been implicated in the pathogenesis of atherogenesis. The aim of our study is to examine whether the plasma 8-iso-prostaglandin F2α level, a marker of oxidative stress, is elevated in patients with acute myocardial infarction.
Methods: Three groups of patients were enrolled: (1) patients with no or minimal coronary artery disease (CAD) (n = 15); (2) patients with stable CAD (n = 31); (3) patients with acute myocardial infarction (n = 13).
Results: Plasma 8-iso-prostaglandin F2α levels were significantly elevated (p < 0.001) in patients with acute myocardial infarction (290.7 ± 73.9 pg/ml) as compared to patients with stable CAD (182.0+75.7 pg/ml) and patients with no significant CAD (118.9 ± 85.5 pg/ml). This remained significant after correcting for coronary atherosclerosis risk factors, age, extent of atherosclerosis, and C-reactive protein (CRP) level.
Conclusion: Plasma 8-iso-prostaglandin F2α levels are elevated in patients with acute myocardial infarction. Endogenous oxidative stress may contribute to the pathogenesis of atherosclerosis and its complications, namely myocardial infarction.</description><subject>artherosclerosis</subject><subject>isoprostanes</subject><subject>myocardial infarction</subject><subject>Oxidative stress</subject><issn>1071-5762</issn><issn>1029-2470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNp1UEFOwzAQtBBIlMIDuPkBDayTOHYEF1RRQKoEBzhHS2xTlySubJe2z-IjvAkjuCDEaUeamd3ZIeSUwRkDCecMBOOiAg7Ai5rxco-MGOR1lpcC9r-wYFkS5IfkKIQlACtKLkZk-9Bh6JHKzAaXrbwLEV86HJQd6Cz_eJ9QpD36V-2pM9RtrcJo3zQN0esQJtQGaofWawxaJURXidZDDHRj44Jiu46a9jvXolcWu6Qw6Nto3XBMDgx2QZ_8zDF5ml0_Tm-z-f3N3fRqnlkmeMzkM8vRqJqXdWE4A8MKLXhVMqmUEnULvKq5LjSHVjBdSSmQy7ISCgqQJjFjcvm9N512vseN851qIu46543HobWhKRg0Xy02f1pM9otf9oXGLi7SO7pZurUfUvTmf_cn0S15Sg</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Elesber, Ahmad A.</creator><creator>Best, Patricia J.</creator><creator>Lennon, Ryan J.</creator><creator>Mathew, Verghese</creator><creator>Rihal, Charanjit S.</creator><creator>Lerman, Lilach O.</creator><creator>Lerman, Amir</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope/></search><sort><creationdate>20060101</creationdate><title>Plasma 8-iso-prostaglandin F2α, a marker of oxidative stress, is increased in patients with acute myocardial infarction</title><author>Elesber, Ahmad A. ; Best, Patricia J. ; Lennon, Ryan J. ; Mathew, Verghese ; Rihal, Charanjit S. ; Lerman, Lilach O. ; Lerman, Amir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i175t-8b12afd95493f510f13e756418ddd79c05695e3e50c71e6887a58467d0308f5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>artherosclerosis</topic><topic>isoprostanes</topic><topic>myocardial infarction</topic><topic>Oxidative stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elesber, Ahmad A.</creatorcontrib><creatorcontrib>Best, Patricia J.</creatorcontrib><creatorcontrib>Lennon, Ryan J.</creatorcontrib><creatorcontrib>Mathew, Verghese</creatorcontrib><creatorcontrib>Rihal, Charanjit S.</creatorcontrib><creatorcontrib>Lerman, Lilach O.</creatorcontrib><creatorcontrib>Lerman, Amir</creatorcontrib><jtitle>Free radical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elesber, Ahmad A.</au><au>Best, Patricia J.</au><au>Lennon, Ryan J.</au><au>Mathew, Verghese</au><au>Rihal, Charanjit S.</au><au>Lerman, Lilach O.</au><au>Lerman, Amir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma 8-iso-prostaglandin F2α, a marker of oxidative stress, is increased in patients with acute myocardial infarction</atitle><jtitle>Free radical research</jtitle><date>2006-01-01</date><risdate>2006</risdate><volume>40</volume><issue>4</issue><spage>385</spage><epage>391</epage><pages>385-391</pages><issn>1071-5762</issn><eissn>1029-2470</eissn><abstract>Background: Oxidative stress has been implicated in the pathogenesis of atherogenesis. The aim of our study is to examine whether the plasma 8-iso-prostaglandin F2α level, a marker of oxidative stress, is elevated in patients with acute myocardial infarction.
Methods: Three groups of patients were enrolled: (1) patients with no or minimal coronary artery disease (CAD) (n = 15); (2) patients with stable CAD (n = 31); (3) patients with acute myocardial infarction (n = 13).
Results: Plasma 8-iso-prostaglandin F2α levels were significantly elevated (p < 0.001) in patients with acute myocardial infarction (290.7 ± 73.9 pg/ml) as compared to patients with stable CAD (182.0+75.7 pg/ml) and patients with no significant CAD (118.9 ± 85.5 pg/ml). This remained significant after correcting for coronary atherosclerosis risk factors, age, extent of atherosclerosis, and C-reactive protein (CRP) level.
Conclusion: Plasma 8-iso-prostaglandin F2α levels are elevated in patients with acute myocardial infarction. Endogenous oxidative stress may contribute to the pathogenesis of atherosclerosis and its complications, namely myocardial infarction.</abstract><pub>Informa UK Ltd</pub><doi>10.1080/10715760500539154</doi><tpages>7</tpages></addata></record> |
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| source | Taylor & Francis Journals Complete |
| subjects | artherosclerosis isoprostanes myocardial infarction Oxidative stress |
| title | Plasma 8-iso-prostaglandin F2α, a marker of oxidative stress, is increased in patients with acute myocardial infarction |
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