Biodistribution of polysorbate 80-coated doxorubicin-loaded [14C]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats

It was recently shown that doxorubicin (DOX) bound to polysorbate-coated nanoparticles (NP) crossed the intact blood-brain barrier (BBB), and thus reached therapeutic concentrations in the brain. Here, we investigated the biodistribution in the brain and in the body of poly(butyl-2-cyano[3-14C]acryl...

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Veröffentlicht in:	Journal of drug targeting 2006-01, Vol.14 (2), p.97-105
Hauptverfasser:	Ambruosi, Alessandra, Khalansky, Alexander S., Yamamoto, Hiromitsu, Gelperina, Svetlana E., Begley, David J., Kreuter, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Blood-Brain Barrier Brain - metabolism Brain Neoplasms - drug therapy Brain Neoplasms - pathology doxorubicin Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Enbucrilate - chemistry Excipients glioblastoma Glioblastoma - drug therapy Glioblastoma - pathology Injections, Intravenous Male nanoparticles Nanostructures Neoplasm Transplantation Particle Size polysorbate 80 Polysorbates - chemistry Rats Rats, Wistar Suspensions Tissue Distribution
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