A METHOD FOR OPTIMIZATION OF PHARMACOKINETIC MODELS

The authors have developed a method for optimizing nonlinear physiologically based pharmacokinetic (PBPK) models using Lagrangian-based or genetic algorithms. The optimization method is demonstrated using PBPK models for pharmacokinetics of nicotine, in which parameters that are not well established...

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Veröffentlicht in:	Toxicology mechanisms and methods 2000, Vol.10 (1), p.41-53
Hauptverfasser:	Holmes, S.L, Ward, R.C, Galam bos, J.D, Strickler, D.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic Algorithm Nicotine Optimization Pharmacokinetic Modeling
Online-Zugang:	Volltext
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