Detection of Chromosome 13q Deletions and IgH Translocations in Patients with Multiple Myeloma by FISH: Comparison with Karyotype Analysis

Multiple myeloma (MM) is a plasma cell dyscrasia characterized by frequent 13q deletions and IgH translocations that have clinical prognostic significance. We evaluated clonal plasma cells by interphase fluorescence in situ hybridization (FISH) and combined with immunofluorescence detection of cytop...

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Veröffentlicht in:	Leukemia & lymphoma 2004-05, Vol.45 (5), p.965-969
Hauptverfasser:	Chang, Hong, Li, Dan, Zhuang, Lihua, Nie, Eileen, Bouman, Derek, Stewart, A Keith, Chun, Kathy
Format:	Artikel
Sprache:	eng
Schlagworte:	13q deletion Adult Aged Chromosome Deletion Chromosomes, Human, Pair 13 Clone Cells - pathology Cytogenetic Analysis - methods Cytogenetic Analysis - standards Female Humans IgH translocation Immunoglobulin Heavy Chains - genetics In Situ Hybridization, Fluorescence - standards Interphase FISH Karyotype Karyotyping Male Middle Aged Multiple myeloma Multiple Myeloma - diagnosis Multiple Myeloma - genetics Prognosis Translocation, Genetic
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