KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS: Clinical, Diagnostic, and Epidemiological Aspects
Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few viruses proven to be associated with tumorigenesis in humans. Its causal association with all clinical and epidemiological variants of Kaposi's sarcoma (KS) is well established. KSHV is also involved in the pathogenesis of pr...
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| Veröffentlicht in: | Critical reviews in clinical laboratory sciences 2005-01, Vol.42 (2), p.101-153 |
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| description | Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few viruses proven to be associated with tumorigenesis in humans. Its causal association with all clinical and epidemiological variants of Kaposi's sarcoma (KS) is well established. KSHV is also involved in the pathogenesis of primary effusion lymphoma (PEL) and a subset of multicentric Castleman's disease (MCD). Possible associations of KSHV with other clinical settings have been extensively examined. The findings from several of these studies are contradictory and are yet to be resolved. Concentrated effort over the last decade, since the initial discovery of KSHV, led to the development of several experimental systems that resulted in a better comprehension of the biological characteristics of KSHV and set the stage for the understanding of mechanisms by which diseases are induced by the virus. The development of molecular, histological, and serological tools for KSHV diagnosis allowed researchers to track the transmission and to study the epidemiology of KSHV. These assays have been applied, in particular in ambiguous cases, in order to confirm clinically and pathologically based diagnoses. Here, we review the advances in the clinical, experimental, diagnostic, and epidemiological research of KSHV. |
| doi_str_mv | 10.1080/10408360590913524 |
| format | Article |
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Its causal association with all clinical and epidemiological variants of Kaposi's sarcoma (KS) is well established. KSHV is also involved in the pathogenesis of primary effusion lymphoma (PEL) and a subset of multicentric Castleman's disease (MCD). Possible associations of KSHV with other clinical settings have been extensively examined. The findings from several of these studies are contradictory and are yet to be resolved. Concentrated effort over the last decade, since the initial discovery of KSHV, led to the development of several experimental systems that resulted in a better comprehension of the biological characteristics of KSHV and set the stage for the understanding of mechanisms by which diseases are induced by the virus. The development of molecular, histological, and serological tools for KSHV diagnosis allowed researchers to track the transmission and to study the epidemiology of KSHV. These assays have been applied, in particular in ambiguous cases, in order to confirm clinically and pathologically based diagnoses. Here, we review the advances in the clinical, experimental, diagnostic, and epidemiological research of KSHV.</description><identifier>ISSN: 1040-8363</identifier><identifier>EISSN: 1549-781X</identifier><identifier>DOI: 10.1080/10408360590913524</identifier><identifier>PMID: 15941082</identifier><identifier>CODEN: CRCLBH</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Herpesvirus 8, Human - pathogenicity ; human herpesvirus 8 ; Humans ; Kaposi's sarcoma ; Kaposi's sarcoma-associated herpesvirus ; Mass Screening - methods ; multicentric Castleman's disease ; primary effusion lymphoma ; Sarcoma, Kaposi - diagnosis ; Sarcoma, Kaposi - epidemiology ; Sarcoma, Kaposi - physiopathology ; Sarcoma, Kaposi - virology ; Viral Proteins - metabolism</subject><ispartof>Critical reviews in clinical laboratory sciences, 2005-01, Vol.42 (2), p.101-153</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>Copyright CRC Press 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-79d243f2b8b5c993574e71e0bb06e3e2e147fe0b5e9d6da1367432f72e0dfda23</citedby><cites>FETCH-LOGICAL-c431t-79d243f2b8b5c993574e71e0bb06e3e2e147fe0b5e9d6da1367432f72e0dfda23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10408360590913524$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10408360590913524$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15941082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, Adina</creatorcontrib><creatorcontrib>Wolf, Dana G.</creatorcontrib><creatorcontrib>Guttman-Yassky, Emma</creatorcontrib><creatorcontrib>Sarid, Ronit</creatorcontrib><title>KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS: Clinical, Diagnostic, and Epidemiological Aspects</title><title>Critical reviews in clinical laboratory sciences</title><addtitle>Crit Rev Clin Lab Sci</addtitle><description>Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few viruses proven to be associated with tumorigenesis in humans. Its causal association with all clinical and epidemiological variants of Kaposi's sarcoma (KS) is well established. KSHV is also involved in the pathogenesis of primary effusion lymphoma (PEL) and a subset of multicentric Castleman's disease (MCD). Possible associations of KSHV with other clinical settings have been extensively examined. The findings from several of these studies are contradictory and are yet to be resolved. Concentrated effort over the last decade, since the initial discovery of KSHV, led to the development of several experimental systems that resulted in a better comprehension of the biological characteristics of KSHV and set the stage for the understanding of mechanisms by which diseases are induced by the virus. The development of molecular, histological, and serological tools for KSHV diagnosis allowed researchers to track the transmission and to study the epidemiology of KSHV. These assays have been applied, in particular in ambiguous cases, in order to confirm clinically and pathologically based diagnoses. Here, we review the advances in the clinical, experimental, diagnostic, and epidemiological research of KSHV.</description><subject>Herpesvirus 8, Human - pathogenicity</subject><subject>human herpesvirus 8</subject><subject>Humans</subject><subject>Kaposi's sarcoma</subject><subject>Kaposi's sarcoma-associated herpesvirus</subject><subject>Mass Screening - methods</subject><subject>multicentric Castleman's disease</subject><subject>primary effusion lymphoma</subject><subject>Sarcoma, Kaposi - diagnosis</subject><subject>Sarcoma, Kaposi - epidemiology</subject><subject>Sarcoma, Kaposi - physiopathology</subject><subject>Sarcoma, Kaposi - virology</subject><subject>Viral Proteins - metabolism</subject><issn>1040-8363</issn><issn>1549-781X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE9v1DAQxS1ERUvhA3BBEYdyacD_EsfQS5SGdkXRVpsWIS6WYzutKyde7KxQvz2udqUKEJxmRvN7TzMPgFcIvkOwgu8RpLAiJSw45IgUmD4BB6igPGcV-vY09WmfJ4Dsg-cx3kEIywQ9A_uo4DQ54APw_XN9uewWb7usq1fN8kud1123bBb1VXuanbery7b7ulhddx-yxtnJKumOs1MrbyYfZ6uOMznprF1bbUbrnb95ALI6ro2a4wuwN0gXzctdPQTXn9qr5jy_WJ4tmvoiV5SgOWdcY0oG3Fd9oTgnBaOGIQP7HpaGGGwQZUMaC8N1qSUiJaMEDwwbqActMTkER1vfdfA_NibOYrRRGefkZPwmipJxhMqqSOCbP8A7vwlTuk3glBTjWwhtIRV8jMEMYh3sKMO9QFA8pC7-Sj1pXu-MN_1o9KNiF3MCTraAnQYfRvnTB6fFLO-dD0OQk7JRkP_5f_xNfmukm2-VDObxg3-rfwF65p2R</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Cohen, Adina</creator><creator>Wolf, Dana G.</creator><creator>Guttman-Yassky, Emma</creator><creator>Sarid, Ronit</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS: Clinical, Diagnostic, and Epidemiological Aspects</title><author>Cohen, Adina ; Wolf, Dana G. ; Guttman-Yassky, Emma ; Sarid, Ronit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-79d243f2b8b5c993574e71e0bb06e3e2e147fe0b5e9d6da1367432f72e0dfda23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Herpesvirus 8, Human - pathogenicity</topic><topic>human herpesvirus 8</topic><topic>Humans</topic><topic>Kaposi's sarcoma</topic><topic>Kaposi's sarcoma-associated herpesvirus</topic><topic>Mass Screening - methods</topic><topic>multicentric Castleman's disease</topic><topic>primary effusion lymphoma</topic><topic>Sarcoma, Kaposi - diagnosis</topic><topic>Sarcoma, Kaposi - epidemiology</topic><topic>Sarcoma, Kaposi - physiopathology</topic><topic>Sarcoma, Kaposi - virology</topic><topic>Viral Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, Adina</creatorcontrib><creatorcontrib>Wolf, Dana G.</creatorcontrib><creatorcontrib>Guttman-Yassky, Emma</creatorcontrib><creatorcontrib>Sarid, Ronit</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Critical reviews in clinical laboratory sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, Adina</au><au>Wolf, Dana G.</au><au>Guttman-Yassky, Emma</au><au>Sarid, Ronit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS: Clinical, Diagnostic, and Epidemiological Aspects</atitle><jtitle>Critical reviews in clinical laboratory sciences</jtitle><addtitle>Crit Rev Clin Lab Sci</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>42</volume><issue>2</issue><spage>101</spage><epage>153</epage><pages>101-153</pages><issn>1040-8363</issn><eissn>1549-781X</eissn><coden>CRCLBH</coden><abstract>Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few viruses proven to be associated with tumorigenesis in humans. Its causal association with all clinical and epidemiological variants of Kaposi's sarcoma (KS) is well established. KSHV is also involved in the pathogenesis of primary effusion lymphoma (PEL) and a subset of multicentric Castleman's disease (MCD). Possible associations of KSHV with other clinical settings have been extensively examined. The findings from several of these studies are contradictory and are yet to be resolved. Concentrated effort over the last decade, since the initial discovery of KSHV, led to the development of several experimental systems that resulted in a better comprehension of the biological characteristics of KSHV and set the stage for the understanding of mechanisms by which diseases are induced by the virus. The development of molecular, histological, and serological tools for KSHV diagnosis allowed researchers to track the transmission and to study the epidemiology of KSHV. These assays have been applied, in particular in ambiguous cases, in order to confirm clinically and pathologically based diagnoses. Here, we review the advances in the clinical, experimental, diagnostic, and epidemiological research of KSHV.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>15941082</pmid><doi>10.1080/10408360590913524</doi><tpages>53</tpages></addata></record> |
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| ispartof | Critical reviews in clinical laboratory sciences, 2005-01, Vol.42 (2), p.101-153 |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals |
| subjects | Herpesvirus 8, Human - pathogenicity human herpesvirus 8 Humans Kaposi's sarcoma Kaposi's sarcoma-associated herpesvirus Mass Screening - methods multicentric Castleman's disease primary effusion lymphoma Sarcoma, Kaposi - diagnosis Sarcoma, Kaposi - epidemiology Sarcoma, Kaposi - physiopathology Sarcoma, Kaposi - virology Viral Proteins - metabolism |
| title | KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS: Clinical, Diagnostic, and Epidemiological Aspects |
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