Background and Radiation-induced 8-hydroxy-2′-deoxyguanosine in γ-irradiated Escherichia Coli

The DNA base damage product, 8-hydroxy-2′-deoxyguanosine (7-hydro-8-oxo-2′-deoxyguanosine, or 8-OHdG) was measured in 2′-deoxyribonucleoside digests of DNA from irradiated E. coli or model DNA using HPLC separation and electrochemical detection (LCED). The LCED technique enabled the specific quantit...

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