Effect of the Inducers of Cellular Differentiation and of Ionizing Radiation of Thymus Lymphocytes: Chromatin Degradation and Programmed Cell Death
Summary The cytotoxic response of thymocytes to chemical inducers of differentiation does not represent a non-specific toxic action of these drugs. The death of thymocytes treated with the inducers or with γ-rays is associated with internucleosomal chromatin fragmentation. All treatments are more ef...
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| Veröffentlicht in: | International journal of radiation biology 1988, Vol.53 (4), p.617-628 |
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| container_end_page | 628 |
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| container_issue | 4 |
| container_start_page | 617 |
| container_title | International journal of radiation biology |
| container_volume | 53 |
| creator | Filippovich, I.V. Sorokina, N.I. Soldatenkov, V.A. Alfyerova, T.M. Trebenok, Z.A. |
| description | Summary
The cytotoxic response of thymocytes to chemical inducers of differentiation does not represent a non-specific toxic action of these drugs. The death of thymocytes treated with the inducers or with γ-rays is associated with internucleosomal chromatin fragmentation. All treatments are more effective on the most radiosensitive sub-population of these cells. This subpopulation is characterized by the maximal level of spontaneous DNA lesions. Incubation of thymocytes with the inducers of differentiation raises the level of these lesions. It is suggested that the processes of thymocyte death after the inducer treatment or irradiation and of cellular differentiation have features in common, and the capacity of thymocytes to limit or reverse the potentially lethal effects of these treatments is determined by the level of pre-existing spontaneous DNA lesions. |
| doi_str_mv | 10.1080/09553008814550941 |
| format | Article |
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The cytotoxic response of thymocytes to chemical inducers of differentiation does not represent a non-specific toxic action of these drugs. The death of thymocytes treated with the inducers or with γ-rays is associated with internucleosomal chromatin fragmentation. All treatments are more effective on the most radiosensitive sub-population of these cells. This subpopulation is characterized by the maximal level of spontaneous DNA lesions. Incubation of thymocytes with the inducers of differentiation raises the level of these lesions. It is suggested that the processes of thymocyte death after the inducer treatment or irradiation and of cellular differentiation have features in common, and the capacity of thymocytes to limit or reverse the potentially lethal effects of these treatments is determined by the level of pre-existing spontaneous DNA lesions.</description><identifier>ISSN: 0955-3002</identifier><identifier>ISSN: 0020-7616</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553008814550941</identifier><identifier>PMID: 3258296</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Butyrates - pharmacology ; Butyric Acid ; Cell Differentiation - drug effects ; Cell Survival - drug effects ; Cell Survival - radiation effects ; Chromatin - drug effects ; Chromatin - radiation effects ; Cobalt Radioisotopes ; Dimethyl Sulfoxide - pharmacology ; Ethionine - pharmacology ; Gamma Rays ; Hypoxanthine ; Hypoxanthines - pharmacology ; Mice ; Radiation Genetics ; T-Lymphocytes - drug effects ; T-Lymphocytes - radiation effects</subject><ispartof>International journal of radiation biology, 1988, Vol.53 (4), p.617-628</ispartof><rights>1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-2b707c8385ee9894d3438e4417b873af7262d4b6fa0191f3ebdbf217a8dc6c0d3</citedby><cites>FETCH-LOGICAL-c430t-2b707c8385ee9894d3438e4417b873af7262d4b6fa0191f3ebdbf217a8dc6c0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553008814550941$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553008814550941$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3258296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Filippovich, I.V.</creatorcontrib><creatorcontrib>Sorokina, N.I.</creatorcontrib><creatorcontrib>Soldatenkov, V.A.</creatorcontrib><creatorcontrib>Alfyerova, T.M.</creatorcontrib><creatorcontrib>Trebenok, Z.A.</creatorcontrib><title>Effect of the Inducers of Cellular Differentiation and of Ionizing Radiation of Thymus Lymphocytes: Chromatin Degradation and Programmed Cell Death</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><description>Summary
The cytotoxic response of thymocytes to chemical inducers of differentiation does not represent a non-specific toxic action of these drugs. The death of thymocytes treated with the inducers or with γ-rays is associated with internucleosomal chromatin fragmentation. All treatments are more effective on the most radiosensitive sub-population of these cells. This subpopulation is characterized by the maximal level of spontaneous DNA lesions. Incubation of thymocytes with the inducers of differentiation raises the level of these lesions. It is suggested that the processes of thymocyte death after the inducer treatment or irradiation and of cellular differentiation have features in common, and the capacity of thymocytes to limit or reverse the potentially lethal effects of these treatments is determined by the level of pre-existing spontaneous DNA lesions.</description><subject>Animals</subject><subject>Butyrates - pharmacology</subject><subject>Butyric Acid</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - radiation effects</subject><subject>Chromatin - drug effects</subject><subject>Chromatin - radiation effects</subject><subject>Cobalt Radioisotopes</subject><subject>Dimethyl Sulfoxide - pharmacology</subject><subject>Ethionine - pharmacology</subject><subject>Gamma Rays</subject><subject>Hypoxanthine</subject><subject>Hypoxanthines - pharmacology</subject><subject>Mice</subject><subject>Radiation Genetics</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - radiation effects</subject><issn>0955-3002</issn><issn>0020-7616</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNtKAzEQhoMotR4ewAshL1BNNnvIqjfSVi0UFKnXSzaH7pbdpCRZZH0NX9jUFkWEXmUy3_z_DD8AFxhdYUTRNcqThCBEKY6TBOUxPgBDTNJoRAI5BMMNDzWKjsGJcysUKkToAAxIlNAoT4fgc6qU5B4aBX0l4UyLjkvrNv-xbJquYRZO6jBjpfY187XRkGmx4TOj649aL-ErEzsSuouqbzsH5327rgzvvXQ3cFxZ04YJDSdyaZn4tXmxJjTaVorvdYEzX52BI8UaJ8937yl4e5guxk-j-fPjbHw_H_GYID-KygxlnBKaSJnTPBYkJlTGMc5KmhGmsiiNRFymiiGcY0VkKUoV4YxRwVOOBDkFeOvLrXHOSlWsbd0y2xcYFZt8i3_5Bs3lVrPuynD1j2IXaOB3W15rZWzL3o1tROFZ3xirLNO8dgXZZ3_7R15J1viKMyuLlemsDnHsOe4LlD-c-A</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Filippovich, I.V.</creator><creator>Sorokina, N.I.</creator><creator>Soldatenkov, V.A.</creator><creator>Alfyerova, T.M.</creator><creator>Trebenok, Z.A.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1988</creationdate><title>Effect of the Inducers of Cellular Differentiation and of Ionizing Radiation of Thymus Lymphocytes: Chromatin Degradation and Programmed Cell Death</title><author>Filippovich, I.V. ; Sorokina, N.I. ; Soldatenkov, V.A. ; Alfyerova, T.M. ; Trebenok, Z.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-2b707c8385ee9894d3438e4417b873af7262d4b6fa0191f3ebdbf217a8dc6c0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Butyrates - pharmacology</topic><topic>Butyric Acid</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - radiation effects</topic><topic>Chromatin - drug effects</topic><topic>Chromatin - radiation effects</topic><topic>Cobalt Radioisotopes</topic><topic>Dimethyl Sulfoxide - pharmacology</topic><topic>Ethionine - pharmacology</topic><topic>Gamma Rays</topic><topic>Hypoxanthine</topic><topic>Hypoxanthines - pharmacology</topic><topic>Mice</topic><topic>Radiation Genetics</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Filippovich, I.V.</creatorcontrib><creatorcontrib>Sorokina, N.I.</creatorcontrib><creatorcontrib>Soldatenkov, V.A.</creatorcontrib><creatorcontrib>Alfyerova, T.M.</creatorcontrib><creatorcontrib>Trebenok, Z.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Filippovich, I.V.</au><au>Sorokina, N.I.</au><au>Soldatenkov, V.A.</au><au>Alfyerova, T.M.</au><au>Trebenok, Z.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the Inducers of Cellular Differentiation and of Ionizing Radiation of Thymus Lymphocytes: Chromatin Degradation and Programmed Cell Death</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><date>1988</date><risdate>1988</risdate><volume>53</volume><issue>4</issue><spage>617</spage><epage>628</epage><pages>617-628</pages><issn>0955-3002</issn><issn>0020-7616</issn><eissn>1362-3095</eissn><abstract>Summary
The cytotoxic response of thymocytes to chemical inducers of differentiation does not represent a non-specific toxic action of these drugs. The death of thymocytes treated with the inducers or with γ-rays is associated with internucleosomal chromatin fragmentation. All treatments are more effective on the most radiosensitive sub-population of these cells. This subpopulation is characterized by the maximal level of spontaneous DNA lesions. Incubation of thymocytes with the inducers of differentiation raises the level of these lesions. It is suggested that the processes of thymocyte death after the inducer treatment or irradiation and of cellular differentiation have features in common, and the capacity of thymocytes to limit or reverse the potentially lethal effects of these treatments is determined by the level of pre-existing spontaneous DNA lesions.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>3258296</pmid><doi>10.1080/09553008814550941</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-3002 |
| ispartof | International journal of radiation biology, 1988, Vol.53 (4), p.617-628 |
| issn | 0955-3002 0020-7616 1362-3095 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_1080_09553008814550941 |
| source | Taylor & Francis:Master (3349 titles); MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | Animals Butyrates - pharmacology Butyric Acid Cell Differentiation - drug effects Cell Survival - drug effects Cell Survival - radiation effects Chromatin - drug effects Chromatin - radiation effects Cobalt Radioisotopes Dimethyl Sulfoxide - pharmacology Ethionine - pharmacology Gamma Rays Hypoxanthine Hypoxanthines - pharmacology Mice Radiation Genetics T-Lymphocytes - drug effects T-Lymphocytes - radiation effects |
| title | Effect of the Inducers of Cellular Differentiation and of Ionizing Radiation of Thymus Lymphocytes: Chromatin Degradation and Programmed Cell Death |
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