Radiosensitivity and Postirradiation Changes of Bone Marrow Clonogenic Stromal Mechanocytes
Summary The in vitro colony assay was used to determine radiosensitivity and post-irradiation changes of guinea pig clonogenic bone marrow stromal fibroblasts (CFU-F). D0 of the CFU-F survival curve proved to be about 200 rad, while n is 1·4. Immediately after total-body exposure to 400 rad and to l...
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| Veröffentlicht in: | International journal of radiation biology 1981, Vol.39 (5), p.537-546 |
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| container_end_page | 546 |
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| container_issue | 5 |
| container_start_page | 537 |
| container_title | International journal of radiation biology |
| container_volume | 39 |
| creator | Friedenstein, A.J. Latzinik, N.V. Gorskaya, U.F. Sidorovich, S.Y. |
| description | Summary
The in vitro colony assay was used to determine radiosensitivity and post-irradiation changes of guinea pig clonogenic bone marrow stromal fibroblasts (CFU-F). D0 of the CFU-F survival curve proved to be about 200 rad, while n is 1·4. Immediately after total-body exposure to 400 rad and to local exposure of tibias to 400 rad, the number of CFU-F diminishes in accordance with D0; it sharply increases after 6 hours and then decreases again. In the period between the eighth and twelfth day following local irradiation, the number of CFU-F doubled in the course of 30-35 hours but later the rate of recovery slowed down. Practically no CFU-F were traced during 3 months after local exposure to 2 krad. |
| doi_str_mv | 10.1080/09553008114550641 |
| format | Article |
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The in vitro colony assay was used to determine radiosensitivity and post-irradiation changes of guinea pig clonogenic bone marrow stromal fibroblasts (CFU-F). D0 of the CFU-F survival curve proved to be about 200 rad, while n is 1·4. Immediately after total-body exposure to 400 rad and to local exposure of tibias to 400 rad, the number of CFU-F diminishes in accordance with D0; it sharply increases after 6 hours and then decreases again. In the period between the eighth and twelfth day following local irradiation, the number of CFU-F doubled in the course of 30-35 hours but later the rate of recovery slowed down. Practically no CFU-F were traced during 3 months after local exposure to 2 krad.</description><identifier>ISSN: 0955-3002</identifier><identifier>ISSN: 0020-7616</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553008114550641</identifier><identifier>PMID: 6972364</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Bone Marrow - radiation effects ; Cell Survival - radiation effects ; Cobalt Radioisotopes ; Colony-Forming Units Assay ; Fibroblasts - radiation effects ; Gamma Rays ; Guinea Pigs ; In Vitro Techniques ; Radiation Tolerance ; X-Rays</subject><ispartof>International journal of radiation biology, 1981, Vol.39 (5), p.537-546</ispartof><rights>1981 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-fd3eff1b63c409e6999d0cfe44f31aa84f8b3b5862b8f307bb6ba6ad3351fff03</citedby><cites>FETCH-LOGICAL-c316t-fd3eff1b63c409e6999d0cfe44f31aa84f8b3b5862b8f307bb6ba6ad3351fff03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553008114550641$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553008114550641$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,777,781,4010,27904,27905,27906,61200,61235,61381,61416</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6972364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Friedenstein, A.J.</creatorcontrib><creatorcontrib>Latzinik, N.V.</creatorcontrib><creatorcontrib>Gorskaya, U.F.</creatorcontrib><creatorcontrib>Sidorovich, S.Y.</creatorcontrib><title>Radiosensitivity and Postirradiation Changes of Bone Marrow Clonogenic Stromal Mechanocytes</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><description>Summary
The in vitro colony assay was used to determine radiosensitivity and post-irradiation changes of guinea pig clonogenic bone marrow stromal fibroblasts (CFU-F). D0 of the CFU-F survival curve proved to be about 200 rad, while n is 1·4. Immediately after total-body exposure to 400 rad and to local exposure of tibias to 400 rad, the number of CFU-F diminishes in accordance with D0; it sharply increases after 6 hours and then decreases again. In the period between the eighth and twelfth day following local irradiation, the number of CFU-F doubled in the course of 30-35 hours but later the rate of recovery slowed down. Practically no CFU-F were traced during 3 months after local exposure to 2 krad.</description><subject>Animals</subject><subject>Bone Marrow - radiation effects</subject><subject>Cell Survival - radiation effects</subject><subject>Cobalt Radioisotopes</subject><subject>Colony-Forming Units Assay</subject><subject>Fibroblasts - radiation effects</subject><subject>Gamma Rays</subject><subject>Guinea Pigs</subject><subject>In Vitro Techniques</subject><subject>Radiation Tolerance</subject><subject>X-Rays</subject><issn>0955-3002</issn><issn>0020-7616</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KAzEUhYMotVYfwIWQFxhNJjPpDK60-Actij8rF8NNJmlTZpKSpErf3pQWN4Kre-A758A9CJ1TcklJRa5IXZaMkIrSoiwJL-gBGlLG84wlcoiGW540yY_RSQhLkhRh1QANeD3OGS-G6PMVWuOCssFE82XiBoNt8YsL0XifEETjLJ4swM5VwE7jW2cVnoH37htPOmfdXFkj8Vv0rocOz5RMXic3UYVTdKShC-psf0fo4_7uffKYTZ8fniY300wyymOmW6a0poIzWZBa8bquWyK1KgrNKEBV6EowUVY8F5VmZCwEF8ChZaykWmvCRojueqV3IXilm5U3PfhNQ0mz3an5s1PKXOwyq7XoVfub2A-T-PWOG6ud72GhoIsLCV41S7f2Nv3zT_sPQI53RQ</recordid><startdate>1981</startdate><enddate>1981</enddate><creator>Friedenstein, A.J.</creator><creator>Latzinik, N.V.</creator><creator>Gorskaya, U.F.</creator><creator>Sidorovich, S.Y.</creator><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1981</creationdate><title>Radiosensitivity and Postirradiation Changes of Bone Marrow Clonogenic Stromal Mechanocytes</title><author>Friedenstein, A.J. ; Latzinik, N.V. ; Gorskaya, U.F. ; Sidorovich, S.Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-fd3eff1b63c409e6999d0cfe44f31aa84f8b3b5862b8f307bb6ba6ad3351fff03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Bone Marrow - radiation effects</topic><topic>Cell Survival - radiation effects</topic><topic>Cobalt Radioisotopes</topic><topic>Colony-Forming Units Assay</topic><topic>Fibroblasts - radiation effects</topic><topic>Gamma Rays</topic><topic>Guinea Pigs</topic><topic>In Vitro Techniques</topic><topic>Radiation Tolerance</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Friedenstein, A.J.</creatorcontrib><creatorcontrib>Latzinik, N.V.</creatorcontrib><creatorcontrib>Gorskaya, U.F.</creatorcontrib><creatorcontrib>Sidorovich, S.Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Friedenstein, A.J.</au><au>Latzinik, N.V.</au><au>Gorskaya, U.F.</au><au>Sidorovich, S.Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiosensitivity and Postirradiation Changes of Bone Marrow Clonogenic Stromal Mechanocytes</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><date>1981</date><risdate>1981</risdate><volume>39</volume><issue>5</issue><spage>537</spage><epage>546</epage><pages>537-546</pages><issn>0955-3002</issn><issn>0020-7616</issn><eissn>1362-3095</eissn><abstract>Summary
The in vitro colony assay was used to determine radiosensitivity and post-irradiation changes of guinea pig clonogenic bone marrow stromal fibroblasts (CFU-F). D0 of the CFU-F survival curve proved to be about 200 rad, while n is 1·4. Immediately after total-body exposure to 400 rad and to local exposure of tibias to 400 rad, the number of CFU-F diminishes in accordance with D0; it sharply increases after 6 hours and then decreases again. In the period between the eighth and twelfth day following local irradiation, the number of CFU-F doubled in the course of 30-35 hours but later the rate of recovery slowed down. Practically no CFU-F were traced during 3 months after local exposure to 2 krad.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>6972364</pmid><doi>10.1080/09553008114550641</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0955-3002 |
| ispartof | International journal of radiation biology, 1981, Vol.39 (5), p.537-546 |
| issn | 0955-3002 0020-7616 1362-3095 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_1080_09553008114550641 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Animals Bone Marrow - radiation effects Cell Survival - radiation effects Cobalt Radioisotopes Colony-Forming Units Assay Fibroblasts - radiation effects Gamma Rays Guinea Pigs In Vitro Techniques Radiation Tolerance X-Rays |
| title | Radiosensitivity and Postirradiation Changes of Bone Marrow Clonogenic Stromal Mechanocytes |
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