Bacterial Radiosensitization by 8-methoxypsoralen
Summary 8-Methoxypsoralen has been shown to act as a radiosensitizer of hypoxic bacterial cells with uvrA recA and uvrB and/or lexA mutations. No effect of the drug on the radiosensitivity of oxic bacteria with these mutations was observed. This drug differs from O2 and electron-affinic radiosensiti...
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| Veröffentlicht in: | International journal of radiation biology 1977-01, Vol.32 (5), p.465-469 |
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| container_end_page | 469 |
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| container_issue | 5 |
| container_start_page | 465 |
| container_title | International journal of radiation biology |
| container_volume | 32 |
| creator | Redpath, J.L. Tortorello, M.L. |
| description | Summary
8-Methoxypsoralen has been shown to act as a radiosensitizer of hypoxic bacterial cells with uvrA recA and uvrB and/or lexA mutations. No effect of the drug on the radiosensitivity of oxic bacteria with these mutations was observed. This drug differs from O2 and electron-affinic radiosensitizers in that its effect is not purely dose-modifying and can exceed the oxygen effect in certain mutants. |
| doi_str_mv | 10.1080/09553007714551221 |
| format | Article |
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8-Methoxypsoralen has been shown to act as a radiosensitizer of hypoxic bacterial cells with uvrA recA and uvrB and/or lexA mutations. No effect of the drug on the radiosensitivity of oxic bacteria with these mutations was observed. This drug differs from O2 and electron-affinic radiosensitizers in that its effect is not purely dose-modifying and can exceed the oxygen effect in certain mutants.</description><identifier>ISSN: 0955-3002</identifier><identifier>ISSN: 0020-7616</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553007714551221</identifier><identifier>PMID: 336567</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Dose-Response Relationship, Radiation ; Electrons ; Escherichia coli - radiation effects ; Methoxsalen - pharmacology ; Mutation ; Oxygen ; Radiation Tolerance ; Radiation-Sensitizing Agents</subject><ispartof>International journal of radiation biology, 1977-01, Vol.32 (5), p.465-469</ispartof><rights>1977 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1977</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c352t-4401bbb95e1e2ef068d1703fc4e8c9b346035598f579980c6898ebc7222cd6dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553007714551221$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553007714551221$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/336567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Redpath, J.L.</creatorcontrib><creatorcontrib>Tortorello, M.L.</creatorcontrib><title>Bacterial Radiosensitization by 8-methoxypsoralen</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><description>Summary
8-Methoxypsoralen has been shown to act as a radiosensitizer of hypoxic bacterial cells with uvrA recA and uvrB and/or lexA mutations. No effect of the drug on the radiosensitivity of oxic bacteria with these mutations was observed. This drug differs from O2 and electron-affinic radiosensitizers in that its effect is not purely dose-modifying and can exceed the oxygen effect in certain mutants.</description><subject>Dose-Response Relationship, Radiation</subject><subject>Electrons</subject><subject>Escherichia coli - radiation effects</subject><subject>Methoxsalen - pharmacology</subject><subject>Mutation</subject><subject>Oxygen</subject><subject>Radiation Tolerance</subject><subject>Radiation-Sensitizing Agents</subject><issn>0955-3002</issn><issn>0020-7616</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9j8tKxDAYhYN4G0cfQHDRF6j-SZo0wZUO3mBAEF2XJP3LZGibIemA49PboeJGcHUOfJwDHyGXFK4pKLgBLQQHKEtaCEEZowdkRrlkOR_JIZnt-diBnZKzlNYwNuDqhBxzLoUsZ4TeGzdg9KbN3kztQ8I--cF_mcGHPrO7TOUdDqvwudukEE2L_Tk5akyb8OIn5-Tj8eF98ZwvX59eFnfL3HHBhrwogFprtUCKDBuQqqYl8MYVqJy2vJDAhdCqEaXWCpxUWqF1JWPM1bJ2fE7o9OtiSCliU22i70zcVRSqvXz1R37cXE2bzdZ2WP8uJtsR307Y902InVmhaYeVMxGrddjGftT55_wbu9dl8A</recordid><startdate>19770101</startdate><enddate>19770101</enddate><creator>Redpath, J.L.</creator><creator>Tortorello, M.L.</creator><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19770101</creationdate><title>Bacterial Radiosensitization by 8-methoxypsoralen</title><author>Redpath, J.L. ; Tortorello, M.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-4401bbb95e1e2ef068d1703fc4e8c9b346035598f579980c6898ebc7222cd6dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Dose-Response Relationship, Radiation</topic><topic>Electrons</topic><topic>Escherichia coli - radiation effects</topic><topic>Methoxsalen - pharmacology</topic><topic>Mutation</topic><topic>Oxygen</topic><topic>Radiation Tolerance</topic><topic>Radiation-Sensitizing Agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Redpath, J.L.</creatorcontrib><creatorcontrib>Tortorello, M.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Redpath, J.L.</au><au>Tortorello, M.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacterial Radiosensitization by 8-methoxypsoralen</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><date>1977-01-01</date><risdate>1977</risdate><volume>32</volume><issue>5</issue><spage>465</spage><epage>469</epage><pages>465-469</pages><issn>0955-3002</issn><issn>0020-7616</issn><eissn>1362-3095</eissn><abstract>Summary
8-Methoxypsoralen has been shown to act as a radiosensitizer of hypoxic bacterial cells with uvrA recA and uvrB and/or lexA mutations. No effect of the drug on the radiosensitivity of oxic bacteria with these mutations was observed. This drug differs from O2 and electron-affinic radiosensitizers in that its effect is not purely dose-modifying and can exceed the oxygen effect in certain mutants.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>336567</pmid><doi>10.1080/09553007714551221</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-3002 |
| ispartof | International journal of radiation biology, 1977-01, Vol.32 (5), p.465-469 |
| issn | 0955-3002 0020-7616 1362-3095 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_1080_09553007714551221 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis |
| subjects | Dose-Response Relationship, Radiation Electrons Escherichia coli - radiation effects Methoxsalen - pharmacology Mutation Oxygen Radiation Tolerance Radiation-Sensitizing Agents |
| title | Bacterial Radiosensitization by 8-methoxypsoralen |
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