Changes in morphogenesis and developmental enzyme levels in Dictyostelium discoideum after gamma irradiation
Summary Changes in the levels of specific activity of two enzymes believed to be involved in developmental regulation were observed after irradiating differentiating cells of Dictyostelium discoideum. Stimulation of the levels of specific activity of alkaline phosphatase occurred after irradiation a...
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| Veröffentlicht in: | International journal of radiation biology 1976-01, Vol.29 (5), p.463-473 |
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| container_end_page | 473 |
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| container_issue | 5 |
| container_start_page | 463 |
| container_title | International journal of radiation biology |
| container_volume | 29 |
| creator | Cleveland, R.F Deering, R.A |
| description | Summary
Changes in the levels of specific activity of two enzymes believed to be involved in developmental regulation were observed after irradiating differentiating cells of Dictyostelium discoideum. Stimulation of the levels of specific activity of alkaline phosphatase occurred after irradiation at the beginning of development and at the end of the aggregation period, but not after irradiation at the beginning of aggregation. A stimulation in UDP-glucose pyrophosphorylase specific activity was also observed, but to a lesser extent and only after irradiation at the end of aggregation. Dose-dependent delays in the appearance of peaks of specific activity were noted. The delay per unit dose was less when irradiation took place at the beginning of development as opposed to the beginning or end of the aggregation period. Radiation-induced delays in progression through visible developmental stages were almost identical to delays in enzyme appearance. Other radiation effects on morphogenesis included the induction of a migratory slug phase. |
| doi_str_mv | 10.1080/09553007614550561 |
| format | Article |
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Changes in the levels of specific activity of two enzymes believed to be involved in developmental regulation were observed after irradiating differentiating cells of Dictyostelium discoideum. Stimulation of the levels of specific activity of alkaline phosphatase occurred after irradiation at the beginning of development and at the end of the aggregation period, but not after irradiation at the beginning of aggregation. A stimulation in UDP-glucose pyrophosphorylase specific activity was also observed, but to a lesser extent and only after irradiation at the end of aggregation. Dose-dependent delays in the appearance of peaks of specific activity were noted. The delay per unit dose was less when irradiation took place at the beginning of development as opposed to the beginning or end of the aggregation period. Radiation-induced delays in progression through visible developmental stages were almost identical to delays in enzyme appearance. Other radiation effects on morphogenesis included the induction of a migratory slug phase.</description><identifier>ISSN: 0020-7616</identifier><identifier>ISSN: 0955-3002</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553007614550561</identifier><identifier>PMID: 1084874</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Alkaline Phosphatase - metabolism ; Cobalt Radioisotopes ; Dictyostelium - enzymology ; Dictyostelium - growth & development ; Dictyostelium - radiation effects ; Dose-Response Relationship, Radiation ; Gamma Rays ; Myxomycetes ; Myxomycetes - radiation effects ; Nucleotidyltransferases - metabolism ; Radiation Effects ; UTP-Glucose-1-Phosphate Uridylyltransferase - metabolism</subject><ispartof>International journal of radiation biology, 1976-01, Vol.29 (5), p.463-473</ispartof><rights>1976 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c377t-c58068eb13f1001d7d02b5dde300ea191397ef9ab7e5b708da9b5969cf72145f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553007614550561$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553007614550561$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,61202,61237,61383,61418</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1084874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cleveland, R.F</creatorcontrib><creatorcontrib>Deering, R.A</creatorcontrib><title>Changes in morphogenesis and developmental enzyme levels in Dictyostelium discoideum after gamma irradiation</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><description>Summary
Changes in the levels of specific activity of two enzymes believed to be involved in developmental regulation were observed after irradiating differentiating cells of Dictyostelium discoideum. Stimulation of the levels of specific activity of alkaline phosphatase occurred after irradiation at the beginning of development and at the end of the aggregation period, but not after irradiation at the beginning of aggregation. A stimulation in UDP-glucose pyrophosphorylase specific activity was also observed, but to a lesser extent and only after irradiation at the end of aggregation. Dose-dependent delays in the appearance of peaks of specific activity were noted. The delay per unit dose was less when irradiation took place at the beginning of development as opposed to the beginning or end of the aggregation period. Radiation-induced delays in progression through visible developmental stages were almost identical to delays in enzyme appearance. Other radiation effects on morphogenesis included the induction of a migratory slug phase.</description><subject>Alkaline Phosphatase - metabolism</subject><subject>Cobalt Radioisotopes</subject><subject>Dictyostelium - enzymology</subject><subject>Dictyostelium - growth & development</subject><subject>Dictyostelium - radiation effects</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Gamma Rays</subject><subject>Myxomycetes</subject><subject>Myxomycetes - radiation effects</subject><subject>Nucleotidyltransferases - metabolism</subject><subject>Radiation Effects</subject><subject>UTP-Glucose-1-Phosphate Uridylyltransferase - metabolism</subject><issn>0020-7616</issn><issn>0955-3002</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFr3DAQhUVJSTZpf0APpfoDTkfWyrLJKWzapLDQQ5uzGVujXQVLWiRvYPvro2R7CARymmEe32PeY-yLgEsBLXyHTikJoBuxVApUIz6whZBNXcminLAFQA1VUZszdp7zA4BadrU8ZaeFXrZ6uWDTaothQ5m7wH1Mu23cUKDsMsdguKFHmuLOU5hx4hT-HTzx6fn4Aty4cT7EPNPk9p4bl8foDJUV7UyJb9B75C4lNA5nF8Mn9tHilOnz_3nB7n_--Lu6q9a_b3-trtfVKLWeq1G10LQ0CGkFgDDaQD0oY6hEJRSdkJ0m2-GgSQ0aWoPdoLqmG62uSxFWXjBx9B1TzDmR7XfJeUyHXkD_XFz_prjCfD0yu_3gybwiXpoq-tVRd8HG5HFLOM3bERP1D3GfQsnzrvu3I20x9rhJLvf3f2oQEiSo8rSUTxHWhkg</recordid><startdate>19760101</startdate><enddate>19760101</enddate><creator>Cleveland, R.F</creator><creator>Deering, R.A</creator><general>Informa UK Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19760101</creationdate><title>Changes in morphogenesis and developmental enzyme levels in Dictyostelium discoideum after gamma irradiation</title><author>Cleveland, R.F ; Deering, R.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-c58068eb13f1001d7d02b5dde300ea191397ef9ab7e5b708da9b5969cf72145f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Alkaline Phosphatase - metabolism</topic><topic>Cobalt Radioisotopes</topic><topic>Dictyostelium - enzymology</topic><topic>Dictyostelium - growth & development</topic><topic>Dictyostelium - radiation effects</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Gamma Rays</topic><topic>Myxomycetes</topic><topic>Myxomycetes - radiation effects</topic><topic>Nucleotidyltransferases - metabolism</topic><topic>Radiation Effects</topic><topic>UTP-Glucose-1-Phosphate Uridylyltransferase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cleveland, R.F</creatorcontrib><creatorcontrib>Deering, R.A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cleveland, R.F</au><au>Deering, R.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in morphogenesis and developmental enzyme levels in Dictyostelium discoideum after gamma irradiation</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><date>1976-01-01</date><risdate>1976</risdate><volume>29</volume><issue>5</issue><spage>463</spage><epage>473</epage><pages>463-473</pages><issn>0020-7616</issn><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>Summary
Changes in the levels of specific activity of two enzymes believed to be involved in developmental regulation were observed after irradiating differentiating cells of Dictyostelium discoideum. Stimulation of the levels of specific activity of alkaline phosphatase occurred after irradiation at the beginning of development and at the end of the aggregation period, but not after irradiation at the beginning of aggregation. A stimulation in UDP-glucose pyrophosphorylase specific activity was also observed, but to a lesser extent and only after irradiation at the end of aggregation. Dose-dependent delays in the appearance of peaks of specific activity were noted. The delay per unit dose was less when irradiation took place at the beginning of development as opposed to the beginning or end of the aggregation period. Radiation-induced delays in progression through visible developmental stages were almost identical to delays in enzyme appearance. Other radiation effects on morphogenesis included the induction of a migratory slug phase.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>1084874</pmid><doi>10.1080/09553007614550561</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7616 |
| ispartof | International journal of radiation biology, 1976-01, Vol.29 (5), p.463-473 |
| issn | 0020-7616 0955-3002 1362-3095 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_1080_09553007614550561 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Alkaline Phosphatase - metabolism Cobalt Radioisotopes Dictyostelium - enzymology Dictyostelium - growth & development Dictyostelium - radiation effects Dose-Response Relationship, Radiation Gamma Rays Myxomycetes Myxomycetes - radiation effects Nucleotidyltransferases - metabolism Radiation Effects UTP-Glucose-1-Phosphate Uridylyltransferase - metabolism |
| title | Changes in morphogenesis and developmental enzyme levels in Dictyostelium discoideum after gamma irradiation |
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