Study of the Therapeutic Effect on Irradiated Mice of Substances Contained in RNA Preparations
Summary Preparations of various types of RNAs injected i.p. (2-5 mg/0·5 ml.) before or after irradiation of mice with lethal or sub-lethal doses produce a significant increase in the survival rate. No difference in the therapeutic effect was observed between homologous RNA (from sucklings) and heter...
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| Veröffentlicht in: | Int. J. Radiat. Biol. 16: 201-9(1969) 1969, Vol.16 (3), p.201-209 |
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| container_title | Int. J. Radiat. Biol. 16: 201-9(1969) |
| container_volume | 16 |
| creator | Ebel, J.P. Beck, G. Keith, G. Langendorff, H. Langendorff, M. |
| description | Summary
Preparations of various types of RNAs injected i.p. (2-5 mg/0·5 ml.) before or after irradiation of mice with lethal or sub-lethal doses produce a significant increase in the survival rate. No difference in the therapeutic effect was observed between homologous RNA (from sucklings) and heterologous RNA (from rat liver or yeast). Extraction methods which favour the molecular integrity of the RNA give active preparations. However, the active substance seems not to be a polyribonucleotide nature although bound to substances in the RNA preparations since it is liberated during dialysis against water. The therapeutic effect does not seem to be related to the presence either of contaminating polypeptides or oligonucleotides. The activity of lipopolysaccharides is discussed. |
| doi_str_mv | 10.1080/09553006914551221 |
| format | Article |
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Preparations of various types of RNAs injected i.p. (2-5 mg/0·5 ml.) before or after irradiation of mice with lethal or sub-lethal doses produce a significant increase in the survival rate. No difference in the therapeutic effect was observed between homologous RNA (from sucklings) and heterologous RNA (from rat liver or yeast). Extraction methods which favour the molecular integrity of the RNA give active preparations. However, the active substance seems not to be a polyribonucleotide nature although bound to substances in the RNA preparations since it is liberated during dialysis against water. The therapeutic effect does not seem to be related to the presence either of contaminating polypeptides or oligonucleotides. The activity of lipopolysaccharides is discussed.</description><identifier>ISSN: 0955-3002</identifier><identifier>ISSN: 0020-7616</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553006914551221</identifier><identifier>PMID: 5307805</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>AMINO ACIDS ; Animals ; Dialysis ; DRUGS ; EUMYCOTA/yeasts, radioprotective effects of RNA from, in mice, x ; LETHAL DOSE ; LIPOPOLYSACCHARIDES ; LIPOPOLYSACCHARIDES/effects on in x-radioprotective effects of RNA preparations in mice ; LIVER ; MICE ; MICE/radiation effects on survival of, protective effects of RNA against x ; N28510 --Life Sciences--Medicine--Protective Substances ; N28620 --Life Sciences--Radiation Effects on Animals--Vertebrates ; NUCLEIC ACID, RIBO-/radioprotective effects of, on survival of mice, x ; NUCLEOTIDES ; NUCLEOTIDES/composition of, effects on x-radioprotective effects of RNA preparations in mice ; PEPTIDES ; POLYMERS ; POLYPEPTIDES ; PROTEINS ; RADIATION EFFECTS ; Radiation Injuries, Experimental - drug therapy ; RADIATION PROTECTION ; Radiation-Protective Agents ; RADIOPROTECTIVE SUBSTANCES ; RATS ; RIBONUCLEIC ACID ; RNA - therapeutic use ; Saccharomyces ; SURVIVAL TIME ; X RADIATION ; X RADIATION/effects on survival of mice, protective effects of RNA against ; YEASTS PEPTIDES/effects on x-radioprotective effects of RNA preparations in mice</subject><ispartof>Int. J. Radiat. Biol. 16: 201-9(1969), 1969, Vol.16 (3), p.201-209</ispartof><rights>1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1969</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-98a45835c8f8af8ff8ea917e1d28d8a90f606a91f954070701525850ca7e1d283</citedby><cites>FETCH-LOGICAL-c428t-98a45835c8f8af8ff8ea917e1d28d8a90f606a91f954070701525850ca7e1d283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553006914551221$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553006914551221$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,881,4010,27900,27901,27902,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5307805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4188606$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Ebel, J.P.</creatorcontrib><creatorcontrib>Beck, G.</creatorcontrib><creatorcontrib>Keith, G.</creatorcontrib><creatorcontrib>Langendorff, H.</creatorcontrib><creatorcontrib>Langendorff, M.</creatorcontrib><creatorcontrib>Laboratoire de Chimie Biologique, Strasbourg</creatorcontrib><title>Study of the Therapeutic Effect on Irradiated Mice of Substances Contained in RNA Preparations</title><title>Int. J. Radiat. Biol. 16: 201-9(1969)</title><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><description>Summary
Preparations of various types of RNAs injected i.p. (2-5 mg/0·5 ml.) before or after irradiation of mice with lethal or sub-lethal doses produce a significant increase in the survival rate. No difference in the therapeutic effect was observed between homologous RNA (from sucklings) and heterologous RNA (from rat liver or yeast). Extraction methods which favour the molecular integrity of the RNA give active preparations. However, the active substance seems not to be a polyribonucleotide nature although bound to substances in the RNA preparations since it is liberated during dialysis against water. The therapeutic effect does not seem to be related to the presence either of contaminating polypeptides or oligonucleotides. The activity of lipopolysaccharides is discussed.</description><subject>AMINO ACIDS</subject><subject>Animals</subject><subject>Dialysis</subject><subject>DRUGS</subject><subject>EUMYCOTA/yeasts, radioprotective effects of RNA from, in mice, x</subject><subject>LETHAL DOSE</subject><subject>LIPOPOLYSACCHARIDES</subject><subject>LIPOPOLYSACCHARIDES/effects on in x-radioprotective effects of RNA preparations in mice</subject><subject>LIVER</subject><subject>MICE</subject><subject>MICE/radiation effects on survival of, protective effects of RNA against x</subject><subject>N28510 --Life Sciences--Medicine--Protective Substances</subject><subject>N28620 --Life Sciences--Radiation Effects on Animals--Vertebrates</subject><subject>NUCLEIC ACID, RIBO-/radioprotective effects of, on survival of mice, x</subject><subject>NUCLEOTIDES</subject><subject>NUCLEOTIDES/composition of, effects on x-radioprotective effects of RNA preparations in mice</subject><subject>PEPTIDES</subject><subject>POLYMERS</subject><subject>POLYPEPTIDES</subject><subject>PROTEINS</subject><subject>RADIATION EFFECTS</subject><subject>Radiation Injuries, Experimental - drug therapy</subject><subject>RADIATION PROTECTION</subject><subject>Radiation-Protective Agents</subject><subject>RADIOPROTECTIVE SUBSTANCES</subject><subject>RATS</subject><subject>RIBONUCLEIC ACID</subject><subject>RNA - therapeutic use</subject><subject>Saccharomyces</subject><subject>SURVIVAL TIME</subject><subject>X RADIATION</subject><subject>X RADIATION/effects on survival of mice, protective effects of RNA against</subject><subject>YEASTS PEPTIDES/effects on x-radioprotective effects of RNA preparations in mice</subject><issn>0955-3002</issn><issn>0020-7616</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMotVY_gAcheK8mu5s2i6dSqhb8h61Xl2l2wqa0SUmyh357U7Z4EWQOM8x7v4F5hFxzdseZZPesFCJnbFTyQgieZfyE9Hk-yoZ5Uk5J_6CnmWXn5CKENUsTy2WP9BI1lkz0yfcitvWeOk1jg3TZoIcdttEoOtMaVaTO0rn3UBuIWNNXo_BgXrSrEMEqDHTqbARjk2gs_Xyb0A-PO_AQjbPhkpxp2AS8OvYB-XqcLafPw5f3p_l08jJURSbjsJRQCJkLJbUELbWWCCUfI68zWUsomR6xUdroUhRsnIqLTEjBFHSefEBuu7suRFMFZSKqRjlr0wtVwaVMfDLxzqS8C8GjrnbebMHvK86qQ57VnzwTc9Mxu3a1xfqXOAaY9IdON1Y7v4UGYRMbBR6rtWu9TU__c_0HOSaA4Q</recordid><startdate>1969</startdate><enddate>1969</enddate><creator>Ebel, J.P.</creator><creator>Beck, G.</creator><creator>Keith, G.</creator><creator>Langendorff, H.</creator><creator>Langendorff, M.</creator><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>1969</creationdate><title>Study of the Therapeutic Effect on Irradiated Mice of Substances Contained in RNA Preparations</title><author>Ebel, J.P. ; Beck, G. ; Keith, G. ; Langendorff, H. ; Langendorff, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-98a45835c8f8af8ff8ea917e1d28d8a90f606a91f954070701525850ca7e1d283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>AMINO ACIDS</topic><topic>Animals</topic><topic>Dialysis</topic><topic>DRUGS</topic><topic>EUMYCOTA/yeasts, radioprotective effects of RNA from, in mice, x</topic><topic>LETHAL DOSE</topic><topic>LIPOPOLYSACCHARIDES</topic><topic>LIPOPOLYSACCHARIDES/effects on in x-radioprotective effects of RNA preparations in mice</topic><topic>LIVER</topic><topic>MICE</topic><topic>MICE/radiation effects on survival of, protective effects of RNA against x</topic><topic>N28510 --Life Sciences--Medicine--Protective Substances</topic><topic>N28620 --Life Sciences--Radiation Effects on Animals--Vertebrates</topic><topic>NUCLEIC ACID, RIBO-/radioprotective effects of, on survival of mice, x</topic><topic>NUCLEOTIDES</topic><topic>NUCLEOTIDES/composition of, effects on x-radioprotective effects of RNA preparations in mice</topic><topic>PEPTIDES</topic><topic>POLYMERS</topic><topic>POLYPEPTIDES</topic><topic>PROTEINS</topic><topic>RADIATION EFFECTS</topic><topic>Radiation Injuries, Experimental - drug therapy</topic><topic>RADIATION PROTECTION</topic><topic>Radiation-Protective Agents</topic><topic>RADIOPROTECTIVE SUBSTANCES</topic><topic>RATS</topic><topic>RIBONUCLEIC ACID</topic><topic>RNA - therapeutic use</topic><topic>Saccharomyces</topic><topic>SURVIVAL TIME</topic><topic>X RADIATION</topic><topic>X RADIATION/effects on survival of mice, protective effects of RNA against</topic><topic>YEASTS PEPTIDES/effects on x-radioprotective effects of RNA preparations in mice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ebel, J.P.</creatorcontrib><creatorcontrib>Beck, G.</creatorcontrib><creatorcontrib>Keith, G.</creatorcontrib><creatorcontrib>Langendorff, H.</creatorcontrib><creatorcontrib>Langendorff, M.</creatorcontrib><creatorcontrib>Laboratoire de Chimie Biologique, Strasbourg</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Int. J. Radiat. Biol. 16: 201-9(1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ebel, J.P.</au><au>Beck, G.</au><au>Keith, G.</au><au>Langendorff, H.</au><au>Langendorff, M.</au><aucorp>Laboratoire de Chimie Biologique, Strasbourg</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of the Therapeutic Effect on Irradiated Mice of Substances Contained in RNA Preparations</atitle><jtitle>Int. J. Radiat. Biol. 16: 201-9(1969)</jtitle><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><date>1969</date><risdate>1969</risdate><volume>16</volume><issue>3</issue><spage>201</spage><epage>209</epage><pages>201-209</pages><issn>0955-3002</issn><issn>0020-7616</issn><eissn>1362-3095</eissn><abstract>Summary
Preparations of various types of RNAs injected i.p. (2-5 mg/0·5 ml.) before or after irradiation of mice with lethal or sub-lethal doses produce a significant increase in the survival rate. No difference in the therapeutic effect was observed between homologous RNA (from sucklings) and heterologous RNA (from rat liver or yeast). Extraction methods which favour the molecular integrity of the RNA give active preparations. However, the active substance seems not to be a polyribonucleotide nature although bound to substances in the RNA preparations since it is liberated during dialysis against water. The therapeutic effect does not seem to be related to the presence either of contaminating polypeptides or oligonucleotides. The activity of lipopolysaccharides is discussed.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>5307805</pmid><doi>10.1080/09553006914551221</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-3002 |
| ispartof | Int. J. Radiat. Biol. 16: 201-9(1969), 1969, Vol.16 (3), p.201-209 |
| issn | 0955-3002 0020-7616 1362-3095 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_1080_09553006914551221 |
| source | Taylor & Francis; MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | AMINO ACIDS Animals Dialysis DRUGS EUMYCOTA/yeasts, radioprotective effects of RNA from, in mice, x LETHAL DOSE LIPOPOLYSACCHARIDES LIPOPOLYSACCHARIDES/effects on in x-radioprotective effects of RNA preparations in mice LIVER MICE MICE/radiation effects on survival of, protective effects of RNA against x N28510 --Life Sciences--Medicine--Protective Substances N28620 --Life Sciences--Radiation Effects on Animals--Vertebrates NUCLEIC ACID, RIBO-/radioprotective effects of, on survival of mice, x NUCLEOTIDES NUCLEOTIDES/composition of, effects on x-radioprotective effects of RNA preparations in mice PEPTIDES POLYMERS POLYPEPTIDES PROTEINS RADIATION EFFECTS Radiation Injuries, Experimental - drug therapy RADIATION PROTECTION Radiation-Protective Agents RADIOPROTECTIVE SUBSTANCES RATS RIBONUCLEIC ACID RNA - therapeutic use Saccharomyces SURVIVAL TIME X RADIATION X RADIATION/effects on survival of mice, protective effects of RNA against YEASTS PEPTIDES/effects on x-radioprotective effects of RNA preparations in mice |
| title | Study of the Therapeutic Effect on Irradiated Mice of Substances Contained in RNA Preparations |
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