The Growth of Murine Lymphomatous Tumour-cells as Determined by Host Survival-time
Summary (1) A cell-dose-survival-time method of study has been developed for the LSA ascites lymphoma of C57Bl/Ka mice for the intraperitoneal and intravenous inoculation of tumour-cells. (2) A growth-model using survival-time as end-point has been experimentally studied. The generation time, as det...
Gespeichert in:
| Veröffentlicht in: | Intern. J. Radiation Biol 1964, Vol.8 (1), p.59-73 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 73 |
|---|---|
| container_issue | 1 |
| container_start_page | 59 |
| container_title | Intern. J. Radiation Biol |
| container_volume | 8 |
| creator | Maruyama, Yosh Brown, Jr, Byron Wm |
| description | Summary
(1) A cell-dose-survival-time method of study has been developed for the LSA ascites lymphoma of C57Bl/Ka mice for the intraperitoneal and intravenous inoculation of tumour-cells.
(2) A growth-model using survival-time as end-point has been experimentally studied. The generation time, as determined indirectly by survival-time, conforms with estimates of this parameter by direct means and suggests that murine lymphomatous tumour-cells grow exponentially during much of their growth in vivo under a given set of conditions. The mean rate of tumour-cell growth may differ according to site of growth. Death apparently occurs at a critical tumour-cell number in the range of inocula studied.
(3) Methods are described for the handling of the experimental data, for the estimation of the generation time, for the threshold number of tumour-cells which, when present in the host, may result in its death.
(4) Whole-body x-irradiation given after the inoculation of the tumour-cells will prolong the survival-time by predictable periods of time. |
| doi_str_mv | 10.1080/09553006414550061 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_osti_</sourceid><recordid>TN_cdi_informahealthcare_journals_10_1080_09553006414550061</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14190708</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-448f078a67d3d99e87df7a98abe6053e40e5d99832a27a8be2bf45ebce883f9e3</originalsourceid><addsrcrecordid>eNp9kNFLwzAQxoMobk7_AF8k-F5NmrRN8UmmbsJE0Plc0vRCO9pmJOlk_70ZHfgg-HQfd7_vuPsQuqbkjhJB7kmeJIyQlFOeJKHSEzSlLI0jFianaHqYB03iCbpwbkOCIkycownlNCcZEVP0sa4BL6z59jU2Gr8NtukBr_bdtjad9GZweD10ZrCRgrZ1WDr8BB5sF7AKl3u8NM7jz8Hump1sI990cInOtGwdXB3rDH29PK_ny2j1vnidP64ixRn1EedCk0zINKtYlecgskpnMheyhJQkDDiBJPQFi2WcSVFCXGqeQKlACKZzYDN0O-4NFzSFU40HVSvT96B8wdMsEZwEiI6QssY5C7rY2qaTdl9QUhxCLP6EGDw3o2c7lB1Uv45jagF4GIGm18Z2sgbZ-lpJC8UmRNWHr_9Z_wO2jH6-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The Growth of Murine Lymphomatous Tumour-cells as Determined by Host Survival-time</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Taylor & Francis Journals Complete</source><creator>Maruyama, Yosh ; Brown, Jr, Byron Wm</creator><creatorcontrib>Maruyama, Yosh ; Brown, Jr, Byron Wm ; Stanford Univ., Calif</creatorcontrib><description>Summary
(1) A cell-dose-survival-time method of study has been developed for the LSA ascites lymphoma of C57Bl/Ka mice for the intraperitoneal and intravenous inoculation of tumour-cells.
(2) A growth-model using survival-time as end-point has been experimentally studied. The generation time, as determined indirectly by survival-time, conforms with estimates of this parameter by direct means and suggests that murine lymphomatous tumour-cells grow exponentially during much of their growth in vivo under a given set of conditions. The mean rate of tumour-cell growth may differ according to site of growth. Death apparently occurs at a critical tumour-cell number in the range of inocula studied.
(3) Methods are described for the handling of the experimental data, for the estimation of the generation time, for the threshold number of tumour-cells which, when present in the host, may result in its death.
(4) Whole-body x-irradiation given after the inoculation of the tumour-cells will prolong the survival-time by predictable periods of time.</description><identifier>ISSN: 0955-3002</identifier><identifier>ISSN: 0020-7616</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553006414550061</identifier><identifier>PMID: 14190708</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>ANIMAL CELLS ; Animals ; BIOLOGY AND MEDICINE ; BODY ; CATTLE ; Cell Division ; DEATH ; ENVIRONMENT ; EXPANSION ; GROWTH ; IN VIVO ; INJECTION ; Injections ; Injections, Intraperitoneal ; Injections, Intravenous ; IRRADIATION ; LYMPH SYSTEM ; Lymphoma ; MICE ; MOCKUP ; Neoplasms - radiotherapy ; Neoplasms, Experimental ; PARASITES ; QUANTITATIVE ANALYSIS ; QUANTITY RATIO ; Radiation Effects ; REPRODUCTION ; Statistics as Topic ; SURVIVAL ; SURVIVAL TIME ; Transplantation ; TUMORS ; X RADIATION</subject><ispartof>Intern. J. Radiation Biol, 1964, Vol.8 (1), p.59-73</ispartof><rights>1964 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1964</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-448f078a67d3d99e87df7a98abe6053e40e5d99832a27a8be2bf45ebce883f9e3</citedby><cites>FETCH-LOGICAL-c431t-448f078a67d3d99e87df7a98abe6053e40e5d99832a27a8be2bf45ebce883f9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553006414550061$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553006414550061$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,885,4022,27921,27922,27923,61219,61254,61400,61435</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14190708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4675840$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Maruyama, Yosh</creatorcontrib><creatorcontrib>Brown, Jr, Byron Wm</creatorcontrib><creatorcontrib>Stanford Univ., Calif</creatorcontrib><title>The Growth of Murine Lymphomatous Tumour-cells as Determined by Host Survival-time</title><title>Intern. J. Radiation Biol</title><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><description>Summary
(1) A cell-dose-survival-time method of study has been developed for the LSA ascites lymphoma of C57Bl/Ka mice for the intraperitoneal and intravenous inoculation of tumour-cells.
(2) A growth-model using survival-time as end-point has been experimentally studied. The generation time, as determined indirectly by survival-time, conforms with estimates of this parameter by direct means and suggests that murine lymphomatous tumour-cells grow exponentially during much of their growth in vivo under a given set of conditions. The mean rate of tumour-cell growth may differ according to site of growth. Death apparently occurs at a critical tumour-cell number in the range of inocula studied.
(3) Methods are described for the handling of the experimental data, for the estimation of the generation time, for the threshold number of tumour-cells which, when present in the host, may result in its death.
(4) Whole-body x-irradiation given after the inoculation of the tumour-cells will prolong the survival-time by predictable periods of time.</description><subject>ANIMAL CELLS</subject><subject>Animals</subject><subject>BIOLOGY AND MEDICINE</subject><subject>BODY</subject><subject>CATTLE</subject><subject>Cell Division</subject><subject>DEATH</subject><subject>ENVIRONMENT</subject><subject>EXPANSION</subject><subject>GROWTH</subject><subject>IN VIVO</subject><subject>INJECTION</subject><subject>Injections</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Intravenous</subject><subject>IRRADIATION</subject><subject>LYMPH SYSTEM</subject><subject>Lymphoma</subject><subject>MICE</subject><subject>MOCKUP</subject><subject>Neoplasms - radiotherapy</subject><subject>Neoplasms, Experimental</subject><subject>PARASITES</subject><subject>QUANTITATIVE ANALYSIS</subject><subject>QUANTITY RATIO</subject><subject>Radiation Effects</subject><subject>REPRODUCTION</subject><subject>Statistics as Topic</subject><subject>SURVIVAL</subject><subject>SURVIVAL TIME</subject><subject>Transplantation</subject><subject>TUMORS</subject><subject>X RADIATION</subject><issn>0955-3002</issn><issn>0020-7616</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1964</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNFLwzAQxoMobk7_AF8k-F5NmrRN8UmmbsJE0Plc0vRCO9pmJOlk_70ZHfgg-HQfd7_vuPsQuqbkjhJB7kmeJIyQlFOeJKHSEzSlLI0jFianaHqYB03iCbpwbkOCIkycownlNCcZEVP0sa4BL6z59jU2Gr8NtukBr_bdtjad9GZweD10ZrCRgrZ1WDr8BB5sF7AKl3u8NM7jz8Hump1sI990cInOtGwdXB3rDH29PK_ny2j1vnidP64ixRn1EedCk0zINKtYlecgskpnMheyhJQkDDiBJPQFi2WcSVFCXGqeQKlACKZzYDN0O-4NFzSFU40HVSvT96B8wdMsEZwEiI6QssY5C7rY2qaTdl9QUhxCLP6EGDw3o2c7lB1Uv45jagF4GIGm18Z2sgbZ-lpJC8UmRNWHr_9Z_wO2jH6-</recordid><startdate>1964</startdate><enddate>1964</enddate><creator>Maruyama, Yosh</creator><creator>Brown, Jr, Byron Wm</creator><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>1964</creationdate><title>The Growth of Murine Lymphomatous Tumour-cells as Determined by Host Survival-time</title><author>Maruyama, Yosh ; Brown, Jr, Byron Wm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-448f078a67d3d99e87df7a98abe6053e40e5d99832a27a8be2bf45ebce883f9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1964</creationdate><topic>ANIMAL CELLS</topic><topic>Animals</topic><topic>BIOLOGY AND MEDICINE</topic><topic>BODY</topic><topic>CATTLE</topic><topic>Cell Division</topic><topic>DEATH</topic><topic>ENVIRONMENT</topic><topic>EXPANSION</topic><topic>GROWTH</topic><topic>IN VIVO</topic><topic>INJECTION</topic><topic>Injections</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Intravenous</topic><topic>IRRADIATION</topic><topic>LYMPH SYSTEM</topic><topic>Lymphoma</topic><topic>MICE</topic><topic>MOCKUP</topic><topic>Neoplasms - radiotherapy</topic><topic>Neoplasms, Experimental</topic><topic>PARASITES</topic><topic>QUANTITATIVE ANALYSIS</topic><topic>QUANTITY RATIO</topic><topic>Radiation Effects</topic><topic>REPRODUCTION</topic><topic>Statistics as Topic</topic><topic>SURVIVAL</topic><topic>SURVIVAL TIME</topic><topic>Transplantation</topic><topic>TUMORS</topic><topic>X RADIATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maruyama, Yosh</creatorcontrib><creatorcontrib>Brown, Jr, Byron Wm</creatorcontrib><creatorcontrib>Stanford Univ., Calif</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Intern. J. Radiation Biol</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maruyama, Yosh</au><au>Brown, Jr, Byron Wm</au><aucorp>Stanford Univ., Calif</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Growth of Murine Lymphomatous Tumour-cells as Determined by Host Survival-time</atitle><jtitle>Intern. J. Radiation Biol</jtitle><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><date>1964</date><risdate>1964</risdate><volume>8</volume><issue>1</issue><spage>59</spage><epage>73</epage><pages>59-73</pages><issn>0955-3002</issn><issn>0020-7616</issn><eissn>1362-3095</eissn><abstract>Summary
(1) A cell-dose-survival-time method of study has been developed for the LSA ascites lymphoma of C57Bl/Ka mice for the intraperitoneal and intravenous inoculation of tumour-cells.
(2) A growth-model using survival-time as end-point has been experimentally studied. The generation time, as determined indirectly by survival-time, conforms with estimates of this parameter by direct means and suggests that murine lymphomatous tumour-cells grow exponentially during much of their growth in vivo under a given set of conditions. The mean rate of tumour-cell growth may differ according to site of growth. Death apparently occurs at a critical tumour-cell number in the range of inocula studied.
(3) Methods are described for the handling of the experimental data, for the estimation of the generation time, for the threshold number of tumour-cells which, when present in the host, may result in its death.
(4) Whole-body x-irradiation given after the inoculation of the tumour-cells will prolong the survival-time by predictable periods of time.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>14190708</pmid><doi>10.1080/09553006414550061</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-3002 |
| ispartof | Intern. J. Radiation Biol, 1964, Vol.8 (1), p.59-73 |
| issn | 0955-3002 0020-7616 1362-3095 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_1080_09553006414550061 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | ANIMAL CELLS Animals BIOLOGY AND MEDICINE BODY CATTLE Cell Division DEATH ENVIRONMENT EXPANSION GROWTH IN VIVO INJECTION Injections Injections, Intraperitoneal Injections, Intravenous IRRADIATION LYMPH SYSTEM Lymphoma MICE MOCKUP Neoplasms - radiotherapy Neoplasms, Experimental PARASITES QUANTITATIVE ANALYSIS QUANTITY RATIO Radiation Effects REPRODUCTION Statistics as Topic SURVIVAL SURVIVAL TIME Transplantation TUMORS X RADIATION |
| title | The Growth of Murine Lymphomatous Tumour-cells as Determined by Host Survival-time |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T20%3A40%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Growth%20of%20Murine%20Lymphomatous%20Tumour-cells%20as%20Determined%20by%20Host%20Survival-time&rft.jtitle=Intern.%20J.%20Radiation%20Biol&rft.au=Maruyama,%20Yosh&rft.aucorp=Stanford%20Univ.,%20Calif&rft.date=1964&rft.volume=8&rft.issue=1&rft.spage=59&rft.epage=73&rft.pages=59-73&rft.issn=0955-3002&rft.eissn=1362-3095&rft_id=info:doi/10.1080/09553006414550061&rft_dat=%3Cpubmed_osti_%3E14190708%3C/pubmed_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/14190708&rfr_iscdi=true |