Experiments on the Radioprotective Action of Dimethyl Sulphoxide
Summary The radioprotective action of dimethyl sulphoxide against a lethal dose of x-rays was investigated in two strains of mice. The protection is somewhat better in CBA/Rij than in C57BL/Rij mice. At protective doses a marked fall in the oxygen tension in the spleen is found. This effect is great...
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| Veröffentlicht in: | International journal of radiation biology 1963-01, Vol.6 (2), p.151-155 |
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| container_title | International journal of radiation biology |
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| creator | van der Meer, C. Valkenburg, P.W. Remmelts, M. |
| description | Summary
The radioprotective action of dimethyl sulphoxide against a lethal dose of x-rays was investigated in two strains of mice. The protection is somewhat better in CBA/Rij than in C57BL/Rij mice. At protective doses a marked fall in the oxygen tension in the spleen is found. This effect is greater in the CBA/Rij than in the C57BL/Rij mice.
The intraperitoneal injection of dimethyl sulphoxide causes an abrupt rise in blood pressure lasting only a few minutes.
The mechanism of action of dimethyl sulphoxide in the mouse is discussed. |
| doi_str_mv | 10.1080/09553006314550151 |
| format | Article |
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The radioprotective action of dimethyl sulphoxide against a lethal dose of x-rays was investigated in two strains of mice. The protection is somewhat better in CBA/Rij than in C57BL/Rij mice. At protective doses a marked fall in the oxygen tension in the spleen is found. This effect is greater in the CBA/Rij than in the C57BL/Rij mice.
The intraperitoneal injection of dimethyl sulphoxide causes an abrupt rise in blood pressure lasting only a few minutes.
The mechanism of action of dimethyl sulphoxide in the mouse is discussed.</description><identifier>ISSN: 0955-3002</identifier><identifier>ISSN: 0020-7616</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553006314550151</identifier><identifier>PMID: 13934424</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>BIOLOGY AND MEDICINE ; Dimethyl Sulfoxide ; LETHAL DOSE ; MICE ; ORGANIC SULFUR COMPOUNDS ; OXYGEN ; QUANTITY RATIO ; RADIATION PROTECTION ; Radiation-Protective Agents ; SPLEEN ; X RADIATION</subject><ispartof>International journal of radiation biology, 1963-01, Vol.6 (2), p.151-155</ispartof><rights>1963 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1963</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-32978d42897ea74dc9614587b299f8bf1d48283b5caf6be5ede77e6f8bf632f43</citedby><cites>FETCH-LOGICAL-c431t-32978d42897ea74dc9614587b299f8bf1d48283b5caf6be5ede77e6f8bf632f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553006314550151$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553006314550151$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,777,781,882,27905,27906,61200,61235,61381,61416</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13934424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4699666$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Meer, C.</creatorcontrib><creatorcontrib>Valkenburg, P.W.</creatorcontrib><creatorcontrib>Remmelts, M.</creatorcontrib><creatorcontrib>National Defence Research Organization TNO, Rijswijk (Z.H.), Netherlands</creatorcontrib><title>Experiments on the Radioprotective Action of Dimethyl Sulphoxide</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><description>Summary
The radioprotective action of dimethyl sulphoxide against a lethal dose of x-rays was investigated in two strains of mice. The protection is somewhat better in CBA/Rij than in C57BL/Rij mice. At protective doses a marked fall in the oxygen tension in the spleen is found. This effect is greater in the CBA/Rij than in the C57BL/Rij mice.
The intraperitoneal injection of dimethyl sulphoxide causes an abrupt rise in blood pressure lasting only a few minutes.
The mechanism of action of dimethyl sulphoxide in the mouse is discussed.</description><subject>BIOLOGY AND MEDICINE</subject><subject>Dimethyl Sulfoxide</subject><subject>LETHAL DOSE</subject><subject>MICE</subject><subject>ORGANIC SULFUR COMPOUNDS</subject><subject>OXYGEN</subject><subject>QUANTITY RATIO</subject><subject>RADIATION PROTECTION</subject><subject>Radiation-Protective Agents</subject><subject>SPLEEN</subject><subject>X RADIATION</subject><issn>0955-3002</issn><issn>0020-7616</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AUhQdRbK3-ADcS3EfnlckMbpRaH1AQfKzDJLlDUtJMmJlK---dkoILwdW9cL5zOfcgdEnwDcES32KVZQxjwQjPMkwycoSmhAmasqgco-lejzumE3Tm_QrHDTN5iiaEKcY55VN0v9gO4No19MEntk9CA8m7rls7OBugCu03JA9xRMma5DGCodl1ycemGxq7bWs4RydGdx4uDnOGvp4Wn_OXdPn2_Dp_WKYVZySkjKpc1pxKlYPOeV0pEUPLvKRKGVkaUnNJJSuzShtRQgY15DmIvSQYNZzN0PV41_rQFr5qY7qmsn0fQxZcKCWEiBAZocpZ7x2YYoi_abcrCC72lRV_Koueq9EzbMo11L-OQ0cRuBuBtjfWrXUDugtNpR0UK7txffz6n_M_npR4Ng</recordid><startdate>19630101</startdate><enddate>19630101</enddate><creator>van der Meer, C.</creator><creator>Valkenburg, P.W.</creator><creator>Remmelts, M.</creator><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19630101</creationdate><title>Experiments on the Radioprotective Action of Dimethyl Sulphoxide</title><author>van der Meer, C. ; Valkenburg, P.W. ; Remmelts, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-32978d42897ea74dc9614587b299f8bf1d48283b5caf6be5ede77e6f8bf632f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1963</creationdate><topic>BIOLOGY AND MEDICINE</topic><topic>Dimethyl Sulfoxide</topic><topic>LETHAL DOSE</topic><topic>MICE</topic><topic>ORGANIC SULFUR COMPOUNDS</topic><topic>OXYGEN</topic><topic>QUANTITY RATIO</topic><topic>RADIATION PROTECTION</topic><topic>Radiation-Protective Agents</topic><topic>SPLEEN</topic><topic>X RADIATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Meer, C.</creatorcontrib><creatorcontrib>Valkenburg, P.W.</creatorcontrib><creatorcontrib>Remmelts, M.</creatorcontrib><creatorcontrib>National Defence Research Organization TNO, Rijswijk (Z.H.), Netherlands</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Meer, C.</au><au>Valkenburg, P.W.</au><au>Remmelts, M.</au><aucorp>National Defence Research Organization TNO, Rijswijk (Z.H.), Netherlands</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experiments on the Radioprotective Action of Dimethyl Sulphoxide</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol Relat Stud Phys Chem Med</addtitle><date>1963-01-01</date><risdate>1963</risdate><volume>6</volume><issue>2</issue><spage>151</spage><epage>155</epage><pages>151-155</pages><issn>0955-3002</issn><issn>0020-7616</issn><eissn>1362-3095</eissn><abstract>Summary
The radioprotective action of dimethyl sulphoxide against a lethal dose of x-rays was investigated in two strains of mice. The protection is somewhat better in CBA/Rij than in C57BL/Rij mice. At protective doses a marked fall in the oxygen tension in the spleen is found. This effect is greater in the CBA/Rij than in the C57BL/Rij mice.
The intraperitoneal injection of dimethyl sulphoxide causes an abrupt rise in blood pressure lasting only a few minutes.
The mechanism of action of dimethyl sulphoxide in the mouse is discussed.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>13934424</pmid><doi>10.1080/09553006314550151</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-3002 |
| ispartof | International journal of radiation biology, 1963-01, Vol.6 (2), p.151-155 |
| issn | 0955-3002 0020-7616 1362-3095 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_1080_09553006314550151 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | BIOLOGY AND MEDICINE Dimethyl Sulfoxide LETHAL DOSE MICE ORGANIC SULFUR COMPOUNDS OXYGEN QUANTITY RATIO RADIATION PROTECTION Radiation-Protective Agents SPLEEN X RADIATION |
| title | Experiments on the Radioprotective Action of Dimethyl Sulphoxide |
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