The Bowman-Birk protease inhibitor enhances clonogenic cell survival of ionizing radiation-treated nucleotide excision repair-competent cells but not of xeroderma pigmentosum cells

Purpose : The radioprotective effect of the Bowman-Birk protease inhibitor (BBI) was previously shown to result from a TP53 dependent mechanism. Whether this effect involves specific DNA repair mechansims is now tested. Material and methods : Normal human fibroblasts were pre-treated with BBI before...

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Veröffentlicht in:	International journal of radiation biology 2000, Vol.76 (2), p.223-229
Hauptverfasser:	DITTMANN, K. H, DIKOMEY, E, MAYER, C, RODEMANN, H. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bleomycin - pharmacology Cell Survival - drug effects Cell Survival - radiation effects Cells, Cultured Cisplatin - pharmacology DNA Repair - drug effects Fundamental and applied biological sciences. Psychology Humans Methylnitronitrosoguanidine - pharmacology Molecular and cellular biology Molecular genetics Mutagenesis. Repair Protease Inhibitors - pharmacology Radiation-Protective Agents - pharmacology Space life sciences Ultraviolet Rays X-Rays Xeroderma Pigmentosum - genetics
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