Evaluation of depressive symptoms in acne patients treated with isotretinoin
Background: There have been concerns about the association between isotretinoin therapy and depressive symptoms. Objective: The objective of this study is to evaluate whether there is an association between isotretinoin therapy and the onset of depression. Methods: A total of 50 patients with modera...
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| Veröffentlicht in: | The Journal of dermatological treatment 2009, Vol.20 (5), p.293-296 |
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| creator | Bozdağ, Kübra Eren Gülseren, Şeref Güven, Füsun Çam, Birmay |
| description | Background: There have been concerns about the association between isotretinoin therapy and depressive symptoms. Objective: The objective of this study is to evaluate whether there is an association between isotretinoin therapy and the onset of depression. Methods: A total of 50 patients with moderate to severe recalcitrant acne and 30 healthy volunteer people were enrolled in the study. Depressive symptoms and anxiety status were assessed at baseline and then 1 and 4 months after the initiation of isotretinoin treatment. Results: We detected improvement in Beck Depression Inventory (BDI) and State and Trait Anxiety Inventory (STAI) scores in acne patients after isotretinoin therapy. Statistically significant improvement in depressive symptoms began at the first month. Improvement in anxiety was detected later than the improvement in depressive symptoms and a statistically significant difference was detected between the first and the second follow-up. Conclusions: Our results provide no relationship between isotretinoin use and depression in acne patients. |
| doi_str_mv | 10.1080/09546630903164909 |
| format | Article |
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Objective: The objective of this study is to evaluate whether there is an association between isotretinoin therapy and the onset of depression. Methods: A total of 50 patients with moderate to severe recalcitrant acne and 30 healthy volunteer people were enrolled in the study. Depressive symptoms and anxiety status were assessed at baseline and then 1 and 4 months after the initiation of isotretinoin treatment. Results: We detected improvement in Beck Depression Inventory (BDI) and State and Trait Anxiety Inventory (STAI) scores in acne patients after isotretinoin therapy. Statistically significant improvement in depressive symptoms began at the first month. Improvement in anxiety was detected later than the improvement in depressive symptoms and a statistically significant difference was detected between the first and the second follow-up. Conclusions: Our results provide no relationship between isotretinoin use and depression in acne patients.</description><identifier>ISSN: 0954-6634</identifier><identifier>EISSN: 1471-1753</identifier><identifier>DOI: 10.1080/09546630903164909</identifier><identifier>PMID: 19701845</identifier><language>eng</language><publisher>Oslo: Informa UK Ltd</publisher><subject>acne ; Acne Vulgaris - drug therapy ; Acne Vulgaris - psychology ; Adolescent ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Depression ; Depressive Disorder - chemically induced ; Depressive Disorder - diagnosis ; Depressive Disorder - epidemiology ; Dermatologic Agents - therapeutic use ; Dermatology ; Drug toxicity and drugs side effects treatment ; Female ; Follow-Up Studies ; Humans ; isotretinoin ; Isotretinoin - therapeutic use ; Male ; Medical sciences ; Mood disorders ; Pharmacology. Drug treatments ; Psychological Tests ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Skin involvement in other diseases. Miscellaneous. General aspects ; Skin, nail, hair, dermoskeleton ; Toxicity: nervous system and muscle ; Young Adult</subject><ispartof>The Journal of dermatological treatment, 2009, Vol.20 (5), p.293-296</ispartof><rights>2009 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-35f659d61b5513d90cd2d5d05f1bbdb3bdeab30439be70299c579675bfac4b103</citedby><cites>FETCH-LOGICAL-c350t-35f659d61b5513d90cd2d5d05f1bbdb3bdeab30439be70299c579675bfac4b103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09546630903164909$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09546630903164909$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21991026$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19701845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bozdağ, Kübra Eren</creatorcontrib><creatorcontrib>Gülseren, Şeref</creatorcontrib><creatorcontrib>Güven, Füsun</creatorcontrib><creatorcontrib>Çam, Birmay</creatorcontrib><title>Evaluation of depressive symptoms in acne patients treated with isotretinoin</title><title>The Journal of dermatological treatment</title><addtitle>J Dermatolog Treat</addtitle><description>Background: There have been concerns about the association between isotretinoin therapy and depressive symptoms. Objective: The objective of this study is to evaluate whether there is an association between isotretinoin therapy and the onset of depression. Methods: A total of 50 patients with moderate to severe recalcitrant acne and 30 healthy volunteer people were enrolled in the study. Depressive symptoms and anxiety status were assessed at baseline and then 1 and 4 months after the initiation of isotretinoin treatment. Results: We detected improvement in Beck Depression Inventory (BDI) and State and Trait Anxiety Inventory (STAI) scores in acne patients after isotretinoin therapy. Statistically significant improvement in depressive symptoms began at the first month. Improvement in anxiety was detected later than the improvement in depressive symptoms and a statistically significant difference was detected between the first and the second follow-up. Conclusions: Our results provide no relationship between isotretinoin use and depression in acne patients.</description><subject>acne</subject><subject>Acne Vulgaris - drug therapy</subject><subject>Acne Vulgaris - psychology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Depressive Disorder - chemically induced</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - epidemiology</subject><subject>Dermatologic Agents - therapeutic use</subject><subject>Dermatology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>isotretinoin</subject><subject>Isotretinoin - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychological Tests</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>Toxicity: nervous system and muscle</subject><subject>Young Adult</subject><issn>0954-6634</issn><issn>1471-1753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo7uzoD_AiuYin1qpOp3uCXmTZVWHAi56bfFQzWbqTNknvMv_eXmZURNhTKPI8L1UvY68Q3iHs4D0o2bStAAUC20aBesI22HRYYSfFU7Z5-K9WoLlglznfAqBoYfecXaDqAHeN3LD99Z0eF118DDwO3NGcKGd_Rzwfp7nEKXMfuLaB-LxSFErmJZEu5Pi9Lwfuc1zn4kP04QV7Nugx08vzu2U_bq6_X32p9t8-f736tK-skFAqIYdWKteikRKFU2Bd7aQDOaAxzgjjSBsBjVCGOqiVsrJTbSfNoG1jEMSWvT3lzin-XCiXfvLZ0jjqQHHJfSeErNVuDd8yPJE2xZwTDf2c_KTTsUfoHzrs_-twdV6f0xczkftrnEtbgTdnQGerxyHpYH3-w9WoFELdrtzHE-fDENOk72MaXV_0cYzptyQe2-PDP_qB9FgOVifqb-OSwtrwI1f8Asdzn0k</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Bozdağ, Kübra Eren</creator><creator>Gülseren, Şeref</creator><creator>Güven, Füsun</creator><creator>Çam, Birmay</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2009</creationdate><title>Evaluation of depressive symptoms in acne patients treated with isotretinoin</title><author>Bozdağ, Kübra Eren ; Gülseren, Şeref ; Güven, Füsun ; Çam, Birmay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-35f659d61b5513d90cd2d5d05f1bbdb3bdeab30439be70299c579675bfac4b103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>acne</topic><topic>Acne Vulgaris - drug therapy</topic><topic>Acne Vulgaris - psychology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Depressive Disorder - chemically induced</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - epidemiology</topic><topic>Dermatologic Agents - therapeutic use</topic><topic>Dermatology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>isotretinoin</topic><topic>Isotretinoin - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychological Tests</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Toxicity: nervous system and muscle</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bozdağ, Kübra Eren</creatorcontrib><creatorcontrib>Gülseren, Şeref</creatorcontrib><creatorcontrib>Güven, Füsun</creatorcontrib><creatorcontrib>Çam, Birmay</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of dermatological treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bozdağ, Kübra Eren</au><au>Gülseren, Şeref</au><au>Güven, Füsun</au><au>Çam, Birmay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of depressive symptoms in acne patients treated with isotretinoin</atitle><jtitle>The Journal of dermatological treatment</jtitle><addtitle>J Dermatolog Treat</addtitle><date>2009</date><risdate>2009</risdate><volume>20</volume><issue>5</issue><spage>293</spage><epage>296</epage><pages>293-296</pages><issn>0954-6634</issn><eissn>1471-1753</eissn><abstract>Background: There have been concerns about the association between isotretinoin therapy and depressive symptoms. Objective: The objective of this study is to evaluate whether there is an association between isotretinoin therapy and the onset of depression. Methods: A total of 50 patients with moderate to severe recalcitrant acne and 30 healthy volunteer people were enrolled in the study. Depressive symptoms and anxiety status were assessed at baseline and then 1 and 4 months after the initiation of isotretinoin treatment. Results: We detected improvement in Beck Depression Inventory (BDI) and State and Trait Anxiety Inventory (STAI) scores in acne patients after isotretinoin therapy. Statistically significant improvement in depressive symptoms began at the first month. Improvement in anxiety was detected later than the improvement in depressive symptoms and a statistically significant difference was detected between the first and the second follow-up. Conclusions: Our results provide no relationship between isotretinoin use and depression in acne patients.</abstract><cop>Oslo</cop><pub>Informa UK Ltd</pub><pmid>19701845</pmid><doi>10.1080/09546630903164909</doi><tpages>4</tpages></addata></record> |
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| subjects | acne Acne Vulgaris - drug therapy Acne Vulgaris - psychology Adolescent Adult Adult and adolescent clinical studies Biological and medical sciences Depression Depressive Disorder - chemically induced Depressive Disorder - diagnosis Depressive Disorder - epidemiology Dermatologic Agents - therapeutic use Dermatology Drug toxicity and drugs side effects treatment Female Follow-Up Studies Humans isotretinoin Isotretinoin - therapeutic use Male Medical sciences Mood disorders Pharmacology. Drug treatments Psychological Tests Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Skin involvement in other diseases. Miscellaneous. General aspects Skin, nail, hair, dermoskeleton Toxicity: nervous system and muscle Young Adult |
| title | Evaluation of depressive symptoms in acne patients treated with isotretinoin |
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