The comparison of bleeding patterns with high-dose and low-dose hormone replacement therapy in postmenopausal women
Our objective was to compare vaginal bleeding patterns with lower doses of conjugated equine estrogen (CEE) and medroxyprogesterone acetate (MPA), in a randomized, double- blind, placebo-controlled trial. A total of 112 healthy, postmenopausal women were divided into three groups. Group A received C...
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| Veröffentlicht in: | Gynecological endocrinology 2004-08, Vol.19 (2), p.64-68 |
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| creator | Kazerooni, T Zolghadri, J |
| description | Our objective was to compare vaginal bleeding patterns with lower doses of conjugated equine estrogen (CEE) and medroxyprogesterone acetate (MPA), in a randomized, double- blind, placebo-controlled trial. A total of 112 healthy, postmenopausal women were divided into three groups. Group A received CEE 0.625 mg/day plus MPA 2.5 mg/day; group B received CEE 0.3 mg/day, plus MPA 1.25 mg/day; and another group received placebo. All medications were continued for 13 months and bleeding data were analyzed in each group. The percentage of patients who experienced no bleeding in cycle one was 45.2% in group B. These values were significantly greater than the figure for group A (18.2%) and lower than in the placebo group (66.7%). A linear trend between time since menopause and cumulative amenorrhea was observed in cases in group B and the placebo group in all cycles (p < 0.05). This finding was significant in only cycle 13 in group A. In conclusion, a higher rate of amenorrhea was observed with a lower-dose regimen of CEE/MPA, which may be the appropriate regimen. |
| doi_str_mv | 10.1080/09513590400002318 |
| format | Article |
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A total of 112 healthy, postmenopausal women were divided into three groups. Group A received CEE 0.625 mg/day plus MPA 2.5 mg/day; group B received CEE 0.3 mg/day, plus MPA 1.25 mg/day; and another group received placebo. All medications were continued for 13 months and bleeding data were analyzed in each group. The percentage of patients who experienced no bleeding in cycle one was 45.2% in group B. These values were significantly greater than the figure for group A (18.2%) and lower than in the placebo group (66.7%). A linear trend between time since menopause and cumulative amenorrhea was observed in cases in group B and the placebo group in all cycles (p < 0.05). This finding was significant in only cycle 13 in group A. 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A total of 112 healthy, postmenopausal women were divided into three groups. Group A received CEE 0.625 mg/day plus MPA 2.5 mg/day; group B received CEE 0.3 mg/day, plus MPA 1.25 mg/day; and another group received placebo. All medications were continued for 13 months and bleeding data were analyzed in each group. The percentage of patients who experienced no bleeding in cycle one was 45.2% in group B. These values were significantly greater than the figure for group A (18.2%) and lower than in the placebo group (66.7%). A linear trend between time since menopause and cumulative amenorrhea was observed in cases in group B and the placebo group in all cycles (p < 0.05). This finding was significant in only cycle 13 in group A. In conclusion, a higher rate of amenorrhea was observed with a lower-dose regimen of CEE/MPA, which may be the appropriate regimen.</description><subject>Amenorrhea</subject><subject>Bleeding Pattern</subject><subject>CEE</subject><subject>Conjugated Equine Estrogens</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Estrogen Replacement Therapy - methods</subject><subject>Estrogens, Conjugated (USP) - administration & dosage</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Humans</subject><subject>Medroxyprogesterone Acetate</subject><subject>Medroxyprogesterone Acetate - administration & dosage</subject><subject>Middle Aged</subject><subject>MPA</subject><subject>Placebos</subject><subject>Postmenopause</subject><subject>Time Factors</subject><subject>Uterine Hemorrhage</subject><issn>0951-3590</issn><issn>1473-0766</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcuKFDEUhoMoTjv6AG4kuHBXmlslVehmGLzBgJtxHVKpU1MZUkmZpGj67U3bDd7Qszmc5Pt_zgWh55S8pqQjb0jfUt72RJAajNPuAdpRoXhDlJQP0e743xyBC_Qk53tCKBeKPUYXtJVMMKl2KN_OgG1cVpNcjgHHCQ8eYHThDq-mFEgh470rM57d3dyMMQM2YcQ-7k_FHNMSA-AEqzcWFggFlxmSWQ_YBbzGXOpbXM2Wjcf7WIun6NFkfIZn53yJvn54f3v9qbn58vHz9dVNYwXrS9PZblRssAOxbUs4oYZZ23fCDlLwkUxTncFI6O3YKiY7oKo3suOqpTBJywW_RK9OvmuK3zbIRS8uW_DeBIhb1lIxokjLK_jyD_A-binU3jTtlSCy_wHRE2RTzDnBpNfkFpMOmhJ9PIf-6xxV8-JsvA0LjD8V5_1X4N0JcGGqizT7mPyoizn4mKZkgnVZ8__5v_1NPoPxZbYmwS8T_FP9HScnq1o</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Kazerooni, T</creator><creator>Zolghadri, J</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>200408</creationdate><title>The comparison of bleeding patterns with high-dose and low-dose hormone replacement therapy in postmenopausal women</title><author>Kazerooni, T ; Zolghadri, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-8c8d72bcb0c550301a2cc984cb643d0ff624a6e9cd57268e179a683751ef6c343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amenorrhea</topic><topic>Bleeding Pattern</topic><topic>CEE</topic><topic>Conjugated Equine Estrogens</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Estrogen Replacement Therapy - methods</topic><topic>Estrogens, Conjugated (USP) - administration & dosage</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Humans</topic><topic>Medroxyprogesterone Acetate</topic><topic>Medroxyprogesterone Acetate - administration & dosage</topic><topic>Middle Aged</topic><topic>MPA</topic><topic>Placebos</topic><topic>Postmenopause</topic><topic>Time Factors</topic><topic>Uterine Hemorrhage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kazerooni, T</creatorcontrib><creatorcontrib>Zolghadri, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecological endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kazerooni, T</au><au>Zolghadri, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The comparison of bleeding patterns with high-dose and low-dose hormone replacement therapy in postmenopausal women</atitle><jtitle>Gynecological endocrinology</jtitle><addtitle>Gynecol Endocrinol</addtitle><date>2004-08</date><risdate>2004</risdate><volume>19</volume><issue>2</issue><spage>64</spage><epage>68</epage><pages>64-68</pages><issn>0951-3590</issn><eissn>1473-0766</eissn><coden>GYENER</coden><abstract>Our objective was to compare vaginal bleeding patterns with lower doses of conjugated equine estrogen (CEE) and medroxyprogesterone acetate (MPA), in a randomized, double- blind, placebo-controlled trial. A total of 112 healthy, postmenopausal women were divided into three groups. Group A received CEE 0.625 mg/day plus MPA 2.5 mg/day; group B received CEE 0.3 mg/day, plus MPA 1.25 mg/day; and another group received placebo. All medications were continued for 13 months and bleeding data were analyzed in each group. The percentage of patients who experienced no bleeding in cycle one was 45.2% in group B. These values were significantly greater than the figure for group A (18.2%) and lower than in the placebo group (66.7%). A linear trend between time since menopause and cumulative amenorrhea was observed in cases in group B and the placebo group in all cycles (p < 0.05). This finding was significant in only cycle 13 in group A. 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| ispartof | Gynecological endocrinology, 2004-08, Vol.19 (2), p.64-68 |
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| source | Taylor & Francis:Master (3349 titles); MEDLINE |
| subjects | Amenorrhea Bleeding Pattern CEE Conjugated Equine Estrogens Dose-Response Relationship, Drug Double-Blind Method Estrogen Replacement Therapy - methods Estrogens, Conjugated (USP) - administration & dosage Female Follicle Stimulating Hormone - blood Humans Medroxyprogesterone Acetate Medroxyprogesterone Acetate - administration & dosage Middle Aged MPA Placebos Postmenopause Time Factors Uterine Hemorrhage |
| title | The comparison of bleeding patterns with high-dose and low-dose hormone replacement therapy in postmenopausal women |
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