Man-Made Mineral Fiber Hazardous Properties Assessment Using Transgenic Rodents: Example of Glass Fiber Testing
Transgenic BigBlue rats were exposed to CM 44 glass fibers (6.3 mg/m 3) by nose only, 6 h/day for 5 days. Two endpoints were examined 1, 3, 14, 28, and 90 days following exposure: fiber biopersistence and mutations in lung DNA. The half-time of the fibers >20 µm was 12.8 days, and mutant frequenc...
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| Veröffentlicht in: | Inhalation toxicology 2003-09, Vol.15 (10), p.1017-1027 |
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| creator | Bottin, M. C. Vigneron, J. C. Rousseau, R. Micillino, J. C. Eypert-Blaison, C. Kauffer, E. Martin, P. Binet, S. Rihn, B. H. |
| description | Transgenic BigBlue rats were exposed to CM 44 glass fibers (6.3 mg/m 3) by nose only, 6 h/day for 5 days. Two endpoints were examined 1, 3, 14, 28, and 90 days following exposure: fiber biopersistence and mutations in lung DNA. The half-time of the fibers >20 µm was 12.8 days, and mutant frequencies of control and exposed rats were similar across all time points. The mutation spectra of both series were similar after 28 days of fixation time. These results showed that a glass fiber with a high clearance in the lung seems to not present any significant effect on mutagenesis on lung DNA and are in marked contrast to results for asbestos, which caused a twofold mutant frequency increase as described in a previous study (Rihn et al., 2000b). |
| doi_str_mv | 10.1080/08958370390226404 |
| format | Article |
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C. ; Vigneron, J. C. ; Rousseau, R. ; Micillino, J. C. ; Eypert-Blaison, C. ; Kauffer, E. ; Martin, P. ; Binet, S. ; Rihn, B. H.</creator><creatorcontrib>Bottin, M. C. ; Vigneron, J. C. ; Rousseau, R. ; Micillino, J. C. ; Eypert-Blaison, C. ; Kauffer, E. ; Martin, P. ; Binet, S. ; Rihn, B. H.</creatorcontrib><description>Transgenic BigBlue rats were exposed to CM 44 glass fibers (6.3 mg/m 3) by nose only, 6 h/day for 5 days. Two endpoints were examined 1, 3, 14, 28, and 90 days following exposure: fiber biopersistence and mutations in lung DNA. The half-time of the fibers >20 µm was 12.8 days, and mutant frequencies of control and exposed rats were similar across all time points. The mutation spectra of both series were similar after 28 days of fixation time. These results showed that a glass fiber with a high clearance in the lung seems to not present any significant effect on mutagenesis on lung DNA and are in marked contrast to results for asbestos, which caused a twofold mutant frequency increase as described in a previous study (Rihn et al., 2000b).</description><identifier>ISSN: 0895-8378</identifier><identifier>EISSN: 1091-7691</identifier><identifier>DOI: 10.1080/08958370390226404</identifier><identifier>PMID: 12928977</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Animals, Genetically Modified ; Bronchoalveolar Lavage ; DNA Damage ; Glass ; glass fibers ; Half-Life ; Inhalation Exposure ; Male ; Mutagenicity Tests ; Rats - genetics ; Rats, Inbred F344 ; Risk Assessment</subject><ispartof>Inhalation toxicology, 2003-09, Vol.15 (10), p.1017-1027</ispartof><rights>2003 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-993ccaaec66755e466847bbe384a428902bcf61caf20470b728acd1e0d5ca5d23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/08958370390226404$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/08958370390226404$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12928977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bottin, M. C.</creatorcontrib><creatorcontrib>Vigneron, J. C.</creatorcontrib><creatorcontrib>Rousseau, R.</creatorcontrib><creatorcontrib>Micillino, J. C.</creatorcontrib><creatorcontrib>Eypert-Blaison, C.</creatorcontrib><creatorcontrib>Kauffer, E.</creatorcontrib><creatorcontrib>Martin, P.</creatorcontrib><creatorcontrib>Binet, S.</creatorcontrib><creatorcontrib>Rihn, B. H.</creatorcontrib><title>Man-Made Mineral Fiber Hazardous Properties Assessment Using Transgenic Rodents: Example of Glass Fiber Testing</title><title>Inhalation toxicology</title><addtitle>Inhal Toxicol</addtitle><description>Transgenic BigBlue rats were exposed to CM 44 glass fibers (6.3 mg/m 3) by nose only, 6 h/day for 5 days. Two endpoints were examined 1, 3, 14, 28, and 90 days following exposure: fiber biopersistence and mutations in lung DNA. The half-time of the fibers >20 µm was 12.8 days, and mutant frequencies of control and exposed rats were similar across all time points. The mutation spectra of both series were similar after 28 days of fixation time. These results showed that a glass fiber with a high clearance in the lung seems to not present any significant effect on mutagenesis on lung DNA and are in marked contrast to results for asbestos, which caused a twofold mutant frequency increase as described in a previous study (Rihn et al., 2000b).</description><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Bronchoalveolar Lavage</subject><subject>DNA Damage</subject><subject>Glass</subject><subject>glass fibers</subject><subject>Half-Life</subject><subject>Inhalation Exposure</subject><subject>Male</subject><subject>Mutagenicity Tests</subject><subject>Rats - genetics</subject><subject>Rats, Inbred F344</subject><subject>Risk Assessment</subject><issn>0895-8378</issn><issn>1091-7691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EokvhA3BBPnEL2I7j2MClqvoHqSsQ2p6tiTNpXSXx4skKyqfH1a6EEFI5jeT5vTfjN4y9luKdFFa8F9Y1tm5F7YRSRgv9hK2kcLJqjZNP2eqhXxXAHrEXRHdCCCPq9jk7ksop69p2xdIa5moNPfJ1nDHDyM9jh5lfwi_IfdoR_5rTFvMSkfgJERJNOC_8muJ8wzcZZrrBOQb-LfXlnT7ws58wbUfkaeAXIxAdDDdIS5G8ZM8GGAlfHeoxuz4_25xeVldfLj6fnlxVQRu9VM7VIQBgMKZtGtTGWN12HdZWgy6rC9WFwcgAgxK6FV2rLIReouibAE2v6mP2du-7zen7rsz2U6SA4wgzll956VTTSCv_D-oy2mpXQLkHQ05EGQe_zXGCfO-l8A_n8P-co2jeHMx33YT9H8Uh_wJ82gNxHlKe4EfKY-8XuB9THkq4IZKvH_P_-Jf8FmFcbgNk9Hdpl-eS8CPb_Qauc6si</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Bottin, M. 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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Animals, Genetically Modified Bronchoalveolar Lavage DNA Damage Glass glass fibers Half-Life Inhalation Exposure Male Mutagenicity Tests Rats - genetics Rats, Inbred F344 Risk Assessment |
| title | Man-Made Mineral Fiber Hazardous Properties Assessment Using Transgenic Rodents: Example of Glass Fiber Testing |
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