Melatonin modifies prolactin release induced by opiate antagonists in male rats
The effect of melatonin on the prolactin (PRL) release induced by treatment with naloxone, naloxone methyliodide, naltrexone and nalmefene were studied in adult male rats. Subcutaneous melatonin injection (1.4 mg/Kg) had no significant effect on serum PRL levels, but decreased by 29% and 26% respect...
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| Veröffentlicht in: | Endocrine research 1995-01, Vol.21 (3), p.545-553 |
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| creator | Shacoori, V. Saiag, B. Rault, B. |
| description | The effect of melatonin on the prolactin (PRL) release induced by treatment with naloxone, naloxone methyliodide, naltrexone and nalmefene were studied in adult male rats. Subcutaneous melatonin injection (1.4 mg/Kg) had no significant effect on serum PRL levels, but decreased by 29% and 26% respectively the inhibitory effect potency of naltrexone (2.5 mg/Kg) and nalmefene (2 mg/Kg) on PRL secretion after simultaneous injections. The inhibitory effect potency of naloxone on PRL release increased (16%) when it was administered with melatonin. Simultaneous injection of melatonin with naloxone methyliodide (2.8 mg/Kg) inhibited PRL release (77.5%) while naloxone methyliodide alone did not modify this secretion. The results obtained with a quaternary opioid antagonist indicate that the opioid receptor type which mediates PRL response is located inside the blood-brain barrier. Our findings show that opiate antagonists and their quaternary ammonium salts affect secretion of PRL through mechanism susceptible to the influence of melatonin. |
| doi_str_mv | 10.1080/07435809509030472 |
| format | Article |
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Subcutaneous melatonin injection (1.4 mg/Kg) had no significant effect on serum PRL levels, but decreased by 29% and 26% respectively the inhibitory effect potency of naltrexone (2.5 mg/Kg) and nalmefene (2 mg/Kg) on PRL secretion after simultaneous injections. The inhibitory effect potency of naloxone on PRL release increased (16%) when it was administered with melatonin. Simultaneous injection of melatonin with naloxone methyliodide (2.8 mg/Kg) inhibited PRL release (77.5%) while naloxone methyliodide alone did not modify this secretion. The results obtained with a quaternary opioid antagonist indicate that the opioid receptor type which mediates PRL response is located inside the blood-brain barrier. Our findings show that opiate antagonists and their quaternary ammonium salts affect secretion of PRL through mechanism susceptible to the influence of melatonin.</description><identifier>ISSN: 0743-5800</identifier><identifier>EISSN: 1532-4206</identifier><identifier>DOI: 10.1080/07435809509030472</identifier><identifier>PMID: 7588425</identifier><language>eng</language><publisher>England: Informa Healthcare USA, Inc</publisher><subject>Animals ; Injections, Subcutaneous ; Male ; Melatonin - administration & dosage ; Melatonin - pharmacology ; Naloxone - analogs & derivatives ; Naloxone - pharmacology ; Naltrexone - analogs & derivatives ; Naltrexone - pharmacology ; Narcotic Antagonists - pharmacology ; Prolactin - secretion ; Quaternary Ammonium Compounds ; Rats ; Rats, Wistar</subject><ispartof>Endocrine research, 1995-01, Vol.21 (3), p.545-553</ispartof><rights>1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-4577cb1f57a2a8eb58f54febf02799c5b99cf408d1d5514f0a5449f2f0f9aa973</citedby><cites>FETCH-LOGICAL-c401t-4577cb1f57a2a8eb58f54febf02799c5b99cf408d1d5514f0a5449f2f0f9aa973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/07435809509030472$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/07435809509030472$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7588425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shacoori, V.</creatorcontrib><creatorcontrib>Saiag, B.</creatorcontrib><creatorcontrib>Rault, B.</creatorcontrib><title>Melatonin modifies prolactin release induced by opiate antagonists in male rats</title><title>Endocrine research</title><addtitle>Endocr Res</addtitle><description>The effect of melatonin on the prolactin (PRL) release induced by treatment with naloxone, naloxone methyliodide, naltrexone and nalmefene were studied in adult male rats. Subcutaneous melatonin injection (1.4 mg/Kg) had no significant effect on serum PRL levels, but decreased by 29% and 26% respectively the inhibitory effect potency of naltrexone (2.5 mg/Kg) and nalmefene (2 mg/Kg) on PRL secretion after simultaneous injections. The inhibitory effect potency of naloxone on PRL release increased (16%) when it was administered with melatonin. Simultaneous injection of melatonin with naloxone methyliodide (2.8 mg/Kg) inhibited PRL release (77.5%) while naloxone methyliodide alone did not modify this secretion. The results obtained with a quaternary opioid antagonist indicate that the opioid receptor type which mediates PRL response is located inside the blood-brain barrier. Our findings show that opiate antagonists and their quaternary ammonium salts affect secretion of PRL through mechanism susceptible to the influence of melatonin.</description><subject>Animals</subject><subject>Injections, Subcutaneous</subject><subject>Male</subject><subject>Melatonin - administration & dosage</subject><subject>Melatonin - pharmacology</subject><subject>Naloxone - analogs & derivatives</subject><subject>Naloxone - pharmacology</subject><subject>Naltrexone - analogs & derivatives</subject><subject>Naltrexone - pharmacology</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Prolactin - secretion</subject><subject>Quaternary Ammonium Compounds</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0743-5800</issn><issn>1532-4206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE-LFDEQxYMo67j6ATwIffLWWukkmw56kcV_sLIXPYfqdMXNku6MSRqZb2-GGQQR9lIF9d7vUTzGXnJ4w2GEt6ClUCMYBQYESD08YjuuxNDLAa4es91R75sBnrJnpdwDcAEgLtiFVuMoB7Vjt98oYk1rWLslzcEHKt0-p4iutlOmSFioC-u8OZq76dClfcBKHa4Vfzas1NIdWYzUZazlOXviMRZ6cd6X7Menj9-vv_Q3t5-_Xn-46Z0EXnuptHYT90rjgCNNavRKepo8DNoYp6Y2vIRx5rNSXHpAJaXxgwdvEI0Wl-z1Kbc9-2ujUu0SiqMYcaW0Fav1lRDcmGbkJ6PLqZRM3u5zWDAfLAd7LNH-V2JjXp3Dt2mh-S9xbq3p7096WH3KC_5OOc624iGm7DOuLhQrHop_9w9-RxjrncNM9j5teW29PfDcHxmMkkw</recordid><startdate>19950101</startdate><enddate>19950101</enddate><creator>Shacoori, V.</creator><creator>Saiag, B.</creator><creator>Rault, B.</creator><general>Informa Healthcare USA, Inc</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950101</creationdate><title>Melatonin modifies prolactin release induced by opiate antagonists in male rats</title><author>Shacoori, V. ; Saiag, B. ; Rault, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-4577cb1f57a2a8eb58f54febf02799c5b99cf408d1d5514f0a5449f2f0f9aa973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Injections, Subcutaneous</topic><topic>Male</topic><topic>Melatonin - administration & dosage</topic><topic>Melatonin - pharmacology</topic><topic>Naloxone - analogs & derivatives</topic><topic>Naloxone - pharmacology</topic><topic>Naltrexone - analogs & derivatives</topic><topic>Naltrexone - pharmacology</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Prolactin - secretion</topic><topic>Quaternary Ammonium Compounds</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shacoori, V.</creatorcontrib><creatorcontrib>Saiag, B.</creatorcontrib><creatorcontrib>Rault, B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shacoori, V.</au><au>Saiag, B.</au><au>Rault, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melatonin modifies prolactin release induced by opiate antagonists in male rats</atitle><jtitle>Endocrine research</jtitle><addtitle>Endocr Res</addtitle><date>1995-01-01</date><risdate>1995</risdate><volume>21</volume><issue>3</issue><spage>545</spage><epage>553</epage><pages>545-553</pages><issn>0743-5800</issn><eissn>1532-4206</eissn><abstract>The effect of melatonin on the prolactin (PRL) release induced by treatment with naloxone, naloxone methyliodide, naltrexone and nalmefene were studied in adult male rats. Subcutaneous melatonin injection (1.4 mg/Kg) had no significant effect on serum PRL levels, but decreased by 29% and 26% respectively the inhibitory effect potency of naltrexone (2.5 mg/Kg) and nalmefene (2 mg/Kg) on PRL secretion after simultaneous injections. The inhibitory effect potency of naloxone on PRL release increased (16%) when it was administered with melatonin. Simultaneous injection of melatonin with naloxone methyliodide (2.8 mg/Kg) inhibited PRL release (77.5%) while naloxone methyliodide alone did not modify this secretion. The results obtained with a quaternary opioid antagonist indicate that the opioid receptor type which mediates PRL response is located inside the blood-brain barrier. Our findings show that opiate antagonists and their quaternary ammonium salts affect secretion of PRL through mechanism susceptible to the influence of melatonin.</abstract><cop>England</cop><pub>Informa Healthcare USA, Inc</pub><pmid>7588425</pmid><doi>10.1080/07435809509030472</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Endocrine research, 1995-01, Vol.21 (3), p.545-553 |
| issn | 0743-5800 1532-4206 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Injections, Subcutaneous Male Melatonin - administration & dosage Melatonin - pharmacology Naloxone - analogs & derivatives Naloxone - pharmacology Naltrexone - analogs & derivatives Naltrexone - pharmacology Narcotic Antagonists - pharmacology Prolactin - secretion Quaternary Ammonium Compounds Rats Rats, Wistar |
| title | Melatonin modifies prolactin release induced by opiate antagonists in male rats |
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