Rituximab-Induced Severe Acute Thrombocytopenia: A case Report and Review of Literature

Rituximab, an anti-CD20 monoclonal antibody, is generally a safe and well-tolerated drug. Severe acute thrombocytopenia following administration of rituximab is a rare phenomenon, with few previously reported cases in the literature. We report a case of an 84-year old male with a diagnosis of mantle...

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Veröffentlicht in:Cancer investigation 2008-01, Vol.26 (9), p.913-915
Hauptverfasser: Dhand, Suneel, Bahrain, Huzefa
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description Rituximab, an anti-CD20 monoclonal antibody, is generally a safe and well-tolerated drug. Severe acute thrombocytopenia following administration of rituximab is a rare phenomenon, with few previously reported cases in the literature. We report a case of an 84-year old male with a diagnosis of mantle cell lymphoma who suffered severe acute thrombocytopenia following rituximab infusion. A literature review of the previously published cases is also presented.
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source Taylor & Francis:Master (3349 titles); MEDLINE; Taylor & Francis Medical Library - CRKN
subjects Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal - adverse effects
Antibodies, Monoclonal - therapeutic use
Antibodies, Monoclonal, Murine-Derived
Antineoplastic Agents - adverse effects
Female
Humans
Lymphoma, Mantle-Cell - drug therapy
Lymphoma, Mantle-Cell - pathology
Male
Mantle cell lymphoma
Middle Aged
Rituximab
Thrombocytopenia
Thrombocytopenia - blood
Thrombocytopenia - diagnosis
Thrombocytopenia - etiology
title Rituximab-Induced Severe Acute Thrombocytopenia: A case Report and Review of Literature
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