Interleukin-1β Gene (IL-1β) Polymorphisms (SNP -511 and SNP +3953) in Thyroid-Associated Ophthalmopathy (TAO) among the Polish Population

Interleukin-1β Gene (IL-1β) Polymorphisms (SNP -511 and SNP +3953) in Thyroid-Associated Ophthalmopathy (TAO) among the Polish Population

Objective: The aim of this study was to evaluate whether the IL-1β gene could be a genetic marker of the thyroid-associated ophthalmopathy (TAO) development. Materials and Methods: The IL-1β gene polymorphisms at -511 and +3953 regions in 117 TAO patients of Polish origin (ATA/NOSPECS class III or g...

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Veröffentlicht in:Current eye research 2009-01, Vol.34 (3), p.215-220
Hauptverfasser: Lacka, Katarzyna, Paradowska, Agnieszka, Gasinska, Teresa, Soszynska, Joanna, Wichary, Hanna, Kramer, Lucyna, Lacki, Jan K.
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IL-1β gene
polymorphisms
susceptibility
TAO
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container_end_page 220
container_issue 3
container_start_page 215
container_title Current eye research
container_volume 34
creator Lacka, Katarzyna
Paradowska, Agnieszka
Gasinska, Teresa
Soszynska, Joanna
Wichary, Hanna
Kramer, Lucyna
Lacki, Jan K.
description Objective: The aim of this study was to evaluate whether the IL-1β gene could be a genetic marker of the thyroid-associated ophthalmopathy (TAO) development. Materials and Methods: The IL-1β gene polymorphisms at -511 and +3953 regions in 117 TAO patients of Polish origin (ATA/NOSPECS class III or greater) and in 106 controls were studied. Results: We found no significant differences in the frequencies of genotypes and allelic variants for SNP -511 and SNP +3953 between the controls and the studied groups. Conclusions: No association between the IL-1β polymorphisms and the TAO existed, so those polymorphisms are not suitable genetic markers for TAO.
doi_str_mv 10.1080/02713680802699390
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Materials and Methods: The IL-1β gene polymorphisms at -511 and +3953 regions in 117 TAO patients of Polish origin (ATA/NOSPECS class III or greater) and in 106 controls were studied. Results: We found no significant differences in the frequencies of genotypes and allelic variants for SNP -511 and SNP +3953 between the controls and the studied groups. Conclusions: No association between the IL-1β polymorphisms and the TAO existed, so those polymorphisms are not suitable genetic markers for TAO.</abstract><pub>Informa UK Ltd</pub><doi>10.1080/02713680802699390</doi><tpages>6</tpages></addata></record>
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subjects IL-1β gene
polymorphisms
susceptibility
TAO
title Interleukin-1β Gene (IL-1β) Polymorphisms (SNP -511 and SNP +3953) in Thyroid-Associated Ophthalmopathy (TAO) among the Polish Population
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