PDGF-BB REGULATES IGF-MEDIATED IGFBP-4 PROTEOLYSIS IN FETAL LUNG FIBROBLASTS

Insulin-like growth factor (IGF)-stimulated lung fibroblast proliferation may be regulated by locally produced IGF-binding proteins (IGFBPs) during lung development. Recent evidence has shown that many growth factors participate in the regulation of cell proliferation by regulating IGFBPs. Because p...

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Veröffentlicht in:	Experimental lung research 2001, Vol.27 (8), p.655-674
1. Verfasser:	Price, Wayne A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Culture Media, Conditioned - chemistry Cyclic AMP - analogs & derivatives Cyclic AMP - pharmacology Edetic Acid - pharmacology Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Igf-BINDING Proteins Igf-BINDING Protein-4 Proteolysis Inflammatory Mediators Insulin-LIKE Growth Factor-I Platelet-DERIVED Growth Factor Insulin-Like Growth Factor Binding Protein 4 - genetics Insulin-Like Growth Factor Binding Protein 4 - metabolism Insulin-Like Growth Factor I - pharmacology Insulin-Like Growth Factor II - pharmacology Lung - cytology Lung - drug effects Lung - embryology Medical sciences Peptide Fragments - pharmacology Phenanthrolines - pharmacology Platelet-Derived Growth Factor - pharmacology Pneumology Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Respiratory system : syndromes and miscellaneous diseases RNA, Messenger - metabolism Thionucleotides - pharmacology
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