ELECTROPHYSIOLOGICAL EVALUATION OF GENITO-SPHINCTERIC DYSFUNCTION IN MULTIPLE SYSTEM ATROPHY
Thirteen patients with multiple system atrophy underwent multimodality neurophysiological evaluation, including sphincteric needle electromyography (EMG), sacral reflexes, pudendal nerve terminal latency, pudendal (PSEPs) and tibialis posterior nerve somatosensory evoked potentials (TPSEPs), and per...
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| Veröffentlicht in: | International journal of neuroscience 2003-10, Vol.113 (10), p.1353-1369 |
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| creator | PELLEGRINETTI, A. MOSCATO, G. SICILIANO, G. BONUCCELLI, U. ORLANDI, G. MARITATO, P. SARTUCCI, F. |
| description | Thirteen patients with multiple system atrophy underwent multimodality neurophysiological evaluation, including sphincteric needle electromyography (EMG), sacral reflexes, pudendal nerve terminal latency, pudendal (PSEPs) and tibialis posterior nerve somatosensory evoked potentials (TPSEPs), and perineal motor evoked potentials (PMEPs). EMG revealed denervation or neurogenic changes, with reduction in spontaneous tonic activity at rest and abnormal pudendal nerve terminal latency in 10 patients (76.9%); anal reflex was delayed in 7 patients (53.8%). TPSEPs scalp responses were clearly abnormal in 4 patients (30.7%), whereas PSEPs exhibited changes in 9 (69.2%): in 6 patients responses were delayed at lumbar level (46.2%), and in 5 over the scalp (38.4%). PMEPs showed an increase in latency with a mild prolongation of central motor conduction time (CMCT) in 2 cases (15.3%); 1 patient had prolonged latencies following both cortical and sacral stimulation, but a normal CMCT. Even if diagnostic yield is not improved using these investigations they provide evidence of multiple lesion sites other than Onuf's nucleus. |
| doi_str_mv | 10.1080/00207450390231428 |
| format | Article |
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EMG revealed denervation or neurogenic changes, with reduction in spontaneous tonic activity at rest and abnormal pudendal nerve terminal latency in 10 patients (76.9%); anal reflex was delayed in 7 patients (53.8%). TPSEPs scalp responses were clearly abnormal in 4 patients (30.7%), whereas PSEPs exhibited changes in 9 (69.2%): in 6 patients responses were delayed at lumbar level (46.2%), and in 5 over the scalp (38.4%). PMEPs showed an increase in latency with a mild prolongation of central motor conduction time (CMCT) in 2 cases (15.3%); 1 patient had prolonged latencies following both cortical and sacral stimulation, but a normal CMCT. Even if diagnostic yield is not improved using these investigations they provide evidence of multiple lesion sites other than Onuf's nucleus.</description><identifier>ISSN: 0020-7454</identifier><identifier>EISSN: 1563-5279</identifier><identifier>EISSN: 1543-5245</identifier><identifier>DOI: 10.1080/00207450390231428</identifier><identifier>PMID: 14534035</identifier><identifier>CODEN: IJNUB7</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Aged ; Anal Canal - innervation ; Anal Canal - physiopathology ; Biological and medical sciences ; Clitoris - innervation ; Clitoris - physiopathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Electric Stimulation ; Electromyography ; Electrophysiology - methods ; Evoked Potentials, Motor ; Evoked Potentials, Somatosensory ; Female ; genito-sphincteric dysfunction ; Humans ; Male ; Medical sciences ; Middle Aged ; motor evoked potentials ; multiple system atrophy ; Multiple System Atrophy - diagnosis ; Multiple System Atrophy - physiopathology ; Neural Conduction ; Neurology ; Penile Erection ; Penis - innervation ; Penis - physiopathology ; Reaction Time ; Reflex ; somatosensory evoked potentials ; Tibial Nerve</subject><ispartof>International journal of neuroscience, 2003-10, Vol.113 (10), p.1353-1369</ispartof><rights>2003 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-a9f586aafb573833671a1c3c2651d71051940b390bbf760cbf0014d4d2a427e63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00207450390231428$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00207450390231428$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,59636,59742,60425,60531,61210,61245,61391,61426</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15218278$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14534035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PELLEGRINETTI, A.</creatorcontrib><creatorcontrib>MOSCATO, G.</creatorcontrib><creatorcontrib>SICILIANO, G.</creatorcontrib><creatorcontrib>BONUCCELLI, U.</creatorcontrib><creatorcontrib>ORLANDI, G.</creatorcontrib><creatorcontrib>MARITATO, P.</creatorcontrib><creatorcontrib>SARTUCCI, F.</creatorcontrib><title>ELECTROPHYSIOLOGICAL EVALUATION OF GENITO-SPHINCTERIC DYSFUNCTION IN MULTIPLE SYSTEM ATROPHY</title><title>International journal of neuroscience</title><addtitle>Int J Neurosci</addtitle><description>Thirteen patients with multiple system atrophy underwent multimodality neurophysiological evaluation, including sphincteric needle electromyography (EMG), sacral reflexes, pudendal nerve terminal latency, pudendal (PSEPs) and tibialis posterior nerve somatosensory evoked potentials (TPSEPs), and perineal motor evoked potentials (PMEPs). EMG revealed denervation or neurogenic changes, with reduction in spontaneous tonic activity at rest and abnormal pudendal nerve terminal latency in 10 patients (76.9%); anal reflex was delayed in 7 patients (53.8%). TPSEPs scalp responses were clearly abnormal in 4 patients (30.7%), whereas PSEPs exhibited changes in 9 (69.2%): in 6 patients responses were delayed at lumbar level (46.2%), and in 5 over the scalp (38.4%). PMEPs showed an increase in latency with a mild prolongation of central motor conduction time (CMCT) in 2 cases (15.3%); 1 patient had prolonged latencies following both cortical and sacral stimulation, but a normal CMCT. Even if diagnostic yield is not improved using these investigations they provide evidence of multiple lesion sites other than Onuf's nucleus.</description><subject>Aged</subject><subject>Anal Canal - innervation</subject><subject>Anal Canal - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Clitoris - innervation</subject><subject>Clitoris - physiopathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Electric Stimulation</subject><subject>Electromyography</subject><subject>Electrophysiology - methods</subject><subject>Evoked Potentials, Motor</subject><subject>Evoked Potentials, Somatosensory</subject><subject>Female</subject><subject>genito-sphincteric dysfunction</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>motor evoked potentials</subject><subject>multiple system atrophy</subject><subject>Multiple System Atrophy - diagnosis</subject><subject>Multiple System Atrophy - physiopathology</subject><subject>Neural Conduction</subject><subject>Neurology</subject><subject>Penile Erection</subject><subject>Penis - innervation</subject><subject>Penis - physiopathology</subject><subject>Reaction Time</subject><subject>Reflex</subject><subject>somatosensory evoked potentials</subject><subject>Tibial Nerve</subject><issn>0020-7454</issn><issn>1563-5279</issn><issn>1543-5245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMoOnQ_wBvpjd5V89m06M2onSvUddhOGAglTVOsdKsmG-K_N2OVIYJX4ZDnfZPzAHCO4DWCPryBEENOGSQBxARR7B-AAWIecRnmwSEYbO9dC9ATMDSmKe1MggD7_jE4QZQRCgkbgJcoicL8KZ1NFlmcJulDHI4SJ3oeJfNRHqdTJx07D9E0zlM3m03iaZhHT3Ho3C-y8dwOWyKeOo_zJI9nSeRkiyyPHp3RrvEMHNWiNWrYn6dgPo7ycOL277iSErx2RVAz3xOiLhknPiEeRwJJIrHHUMURZCigsLR7lmXNPSjLGkJEK1phQTFXHjkFV7ved919bJRZF8vGSNW2YqW6jSk449aT51sQ7UCpO2O0qot33SyF_ioQLLZWiz9WbeaiL9-US1XtE71DC1z2gDBStLUWK9mYPccw8jHfFt3tuGZVd3opPjvdVsVafLWd_gmR__5x-yv-qkS7fpVCq-Kt2-iVFfzPFt9okJsg</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>PELLEGRINETTI, A.</creator><creator>MOSCATO, G.</creator><creator>SICILIANO, G.</creator><creator>BONUCCELLI, U.</creator><creator>ORLANDI, G.</creator><creator>MARITATO, P.</creator><creator>SARTUCCI, F.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>ELECTROPHYSIOLOGICAL EVALUATION OF GENITO-SPHINCTERIC DYSFUNCTION IN MULTIPLE SYSTEM ATROPHY</title><author>PELLEGRINETTI, A. ; MOSCATO, G. ; SICILIANO, G. ; BONUCCELLI, U. ; ORLANDI, G. ; MARITATO, P. ; SARTUCCI, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-a9f586aafb573833671a1c3c2651d71051940b390bbf760cbf0014d4d2a427e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Anal Canal - innervation</topic><topic>Anal Canal - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Clitoris - innervation</topic><topic>Clitoris - physiopathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Electric Stimulation</topic><topic>Electromyography</topic><topic>Electrophysiology - methods</topic><topic>Evoked Potentials, Motor</topic><topic>Evoked Potentials, Somatosensory</topic><topic>Female</topic><topic>genito-sphincteric dysfunction</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>motor evoked potentials</topic><topic>multiple system atrophy</topic><topic>Multiple System Atrophy - diagnosis</topic><topic>Multiple System Atrophy - physiopathology</topic><topic>Neural Conduction</topic><topic>Neurology</topic><topic>Penile Erection</topic><topic>Penis - innervation</topic><topic>Penis - physiopathology</topic><topic>Reaction Time</topic><topic>Reflex</topic><topic>somatosensory evoked potentials</topic><topic>Tibial Nerve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PELLEGRINETTI, A.</creatorcontrib><creatorcontrib>MOSCATO, G.</creatorcontrib><creatorcontrib>SICILIANO, G.</creatorcontrib><creatorcontrib>BONUCCELLI, U.</creatorcontrib><creatorcontrib>ORLANDI, G.</creatorcontrib><creatorcontrib>MARITATO, P.</creatorcontrib><creatorcontrib>SARTUCCI, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PELLEGRINETTI, A.</au><au>MOSCATO, G.</au><au>SICILIANO, G.</au><au>BONUCCELLI, U.</au><au>ORLANDI, G.</au><au>MARITATO, P.</au><au>SARTUCCI, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ELECTROPHYSIOLOGICAL EVALUATION OF GENITO-SPHINCTERIC DYSFUNCTION IN MULTIPLE SYSTEM ATROPHY</atitle><jtitle>International journal of neuroscience</jtitle><addtitle>Int J Neurosci</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>113</volume><issue>10</issue><spage>1353</spage><epage>1369</epage><pages>1353-1369</pages><issn>0020-7454</issn><eissn>1563-5279</eissn><eissn>1543-5245</eissn><coden>IJNUB7</coden><abstract>Thirteen patients with multiple system atrophy underwent multimodality neurophysiological evaluation, including sphincteric needle electromyography (EMG), sacral reflexes, pudendal nerve terminal latency, pudendal (PSEPs) and tibialis posterior nerve somatosensory evoked potentials (TPSEPs), and perineal motor evoked potentials (PMEPs). EMG revealed denervation or neurogenic changes, with reduction in spontaneous tonic activity at rest and abnormal pudendal nerve terminal latency in 10 patients (76.9%); anal reflex was delayed in 7 patients (53.8%). TPSEPs scalp responses were clearly abnormal in 4 patients (30.7%), whereas PSEPs exhibited changes in 9 (69.2%): in 6 patients responses were delayed at lumbar level (46.2%), and in 5 over the scalp (38.4%). PMEPs showed an increase in latency with a mild prolongation of central motor conduction time (CMCT) in 2 cases (15.3%); 1 patient had prolonged latencies following both cortical and sacral stimulation, but a normal CMCT. Even if diagnostic yield is not improved using these investigations they provide evidence of multiple lesion sites other than Onuf's nucleus.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>14534035</pmid><doi>10.1080/00207450390231428</doi><tpages>17</tpages></addata></record> |
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| subjects | Aged Anal Canal - innervation Anal Canal - physiopathology Biological and medical sciences Clitoris - innervation Clitoris - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electric Stimulation Electromyography Electrophysiology - methods Evoked Potentials, Motor Evoked Potentials, Somatosensory Female genito-sphincteric dysfunction Humans Male Medical sciences Middle Aged motor evoked potentials multiple system atrophy Multiple System Atrophy - diagnosis Multiple System Atrophy - physiopathology Neural Conduction Neurology Penile Erection Penis - innervation Penis - physiopathology Reaction Time Reflex somatosensory evoked potentials Tibial Nerve |
| title | ELECTROPHYSIOLOGICAL EVALUATION OF GENITO-SPHINCTERIC DYSFUNCTION IN MULTIPLE SYSTEM ATROPHY |
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