Activated PMNs lead to oxidative stress on chondrocytes: A study of swine knees

Using an in vitro model, based on primary cultured chondrocytes, we examined possible oxidative injury caused by activated polymorphonuclear neutrophil granulocytes (PMNs), which are thought to be part of the pathomechanism of hemarthrosis. Chondrocytes were isolated from swine knee joints and divid...

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Veröffentlicht in:	Acta orthopaedica 2003-04, Vol.74 (2), p.190-195
Hauptverfasser:	Borsiczky, Balázs, Szabó, Zsolt, Jaberansari, Mohammad T, Mack, Peter P O, Röth, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - metabolism Animals Biological and medical sciences Cartilage, Articular - cytology Cartilage, Articular - metabolism Cartilage, Articular - pathology Cells, Cultured Chondrocytes - drug effects Chondrocytes - metabolism Chondrocytes - pathology Diseases of the osteoarticular system Free Radical Scavengers - metabolism Glutathione - metabolism Hemarthrosis - pathology Hemarthrosis - physiopathology Hydrogen Peroxide - pharmacology Knee Joint Lipid Peroxidation Malondialdehyde - metabolism Medical sciences Miscellaneous. Osteoarticular involvement in other diseases Neutrophil Activation - physiology Oxidants - pharmacology Oxidative Stress Superoxide Dismutase - metabolism Swine
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