Experimental investigation of contrast microbubble destruction
The threshold and rate of destruction of Sonazoid and Optison microbubbles insonified by 2-3 MHz imaging pulses have been investigated using a high-resolution 25 MHz active acoustic detector. Almost no microbubbles were destroyed by 2.5 MHz, 4 cycle imaging pulses with acoustic pressures less than 0...
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| creator | Shi, W.T. Forsberg, F. Tornes, A. Ostensen, J. Goldberg, B.B. |
| description | The threshold and rate of destruction of Sonazoid and Optison microbubbles insonified by 2-3 MHz imaging pulses have been investigated using a high-resolution 25 MHz active acoustic detector. Almost no microbubbles were destroyed by 2.5 MHz, 4 cycle imaging pulses with acoustic pressures less than 0.6 and 0.4 MPa for Sonazoid and Optison, respectively. Above threshold acoustic pressures the destruction rate of Sonazoid correlated well (r=0.97) with time-averaged acoustic intensity but poorly (r=0.06) with mechanical index, indicating that time-averaged acoustic intensity can be used as an index for accurately predicting the destruction rate of contrast microbubbles. |
| doi_str_mv | 10.1109/ULTSYM.2001.992047 |
| format | Conference Proceeding |
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Proceedings. An International Symposium (Cat. No.01CH37263)</btitle><stitle>ULTSYM</stitle><date>2001</date><risdate>2001</risdate><volume>2</volume><spage>1691</spage><epage>1694 vol.2</epage><pages>1691-1694 vol.2</pages><isbn>0780371771</isbn><isbn>9780780371774</isbn><abstract>The threshold and rate of destruction of Sonazoid and Optison microbubbles insonified by 2-3 MHz imaging pulses have been investigated using a high-resolution 25 MHz active acoustic detector. Almost no microbubbles were destroyed by 2.5 MHz, 4 cycle imaging pulses with acoustic pressures less than 0.6 and 0.4 MPa for Sonazoid and Optison, respectively. Above threshold acoustic pressures the destruction rate of Sonazoid correlated well (r=0.97) with time-averaged acoustic intensity but poorly (r=0.06) with mechanical index, indicating that time-averaged acoustic intensity can be used as an index for accurately predicting the destruction rate of contrast microbubbles.</abstract><pub>IEEE</pub><doi>10.1109/ULTSYM.2001.992047</doi></addata></record> |
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| language | eng |
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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Acoustic imaging Acoustic pulses Acoustic signal detection Biomedical acoustics Detectors Frequency Optical imaging Optical scattering Pulse amplifiers Ultrasonic imaging |
| title | Experimental investigation of contrast microbubble destruction |
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