Problem of Domain/Building Block Preservation in the Evolution of Biological Macromolecules and Evolutionary Computation

Structurally and functionally isolated domains in biological macromolecular evolution, both natural and artificial, are largely similar to "schemata", building blocks (BBs), in evolutionary computation (EC). The problem of preserving in subsequent evolutionary searches the already found do...

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Veröffentlicht in:	IEEE/ACM transactions on computational biology and bioinformatics 2023-03, Vol.20 (2), p.1345-1362
Hauptverfasser:	Spirov, Alexander V., Myasnikova, Ekaterina M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological computing Biological evolution Biology building block identification building blocks chimeric protein libraries optimization conservative protein domains cross disciplinary knowledge transfer DNA shuffling estimation of distribution algorithms Evolution Evolution (biology) evolution of biological macromolecules Evolutionary algorithms Evolutionary computation Genetic algorithms Identification methods In Vitro evolution Macromolecules Mathematical models Models, Statistical modularity multi-parent recombination Optimization Probabilistic models Proteins Recombination Research Design Sociology Statistics Synthetic Biology Systems Biology transfer of algorithms
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