Performance Evaluation of Dielectrically Modulated Extended Gate Single Cavity InGaAs/Si HTFET Based Label-Free Biosensor Considering Non-Ideal Issues

The dielectrically modulated heterostructure TFET based nanocavity embedded label-free biosensors are emerging as low power, highly sensitive bio-analyte detectors. High sensitivity and fast detection of biomolecules are still a challenge for researchers. In this article, single cavity dual-material...

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Veröffentlicht in:IEEE sensors journal 2021-02, Vol.21 (4), p.4739-4746
Hauptverfasser: Mukhopadhyay, Swarnav, Sen, Dipanjan, Goswami, Bijoy, Sarkar, Subir Kumar
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creator Mukhopadhyay, Swarnav
Sen, Dipanjan
Goswami, Bijoy
Sarkar, Subir Kumar
description The dielectrically modulated heterostructure TFET based nanocavity embedded label-free biosensors are emerging as low power, highly sensitive bio-analyte detectors. High sensitivity and fast detection of biomolecules are still a challenge for researchers. In this article, single cavity dual-material extended gate heterostructure (III-V) TFET (SC-DM-EG HTFET) based dielectrically modulated label-free biosensor is proposed; which promises higher sensitivity and better device performances such as, ON current, \text{I}_{ON}/\text{I}_{OFF} ratio, subthreshold swing (SS); compared with single cavity dual-material heterostructure TFET (SC-DM HTFET), dual cavity dual-material heterostructure TFET (DC-DM HTFET), as well as, previously proposed FET based biosensors. 2D numerical simulation of the biosensors was performed with SILVACO ATLAS 2D simulation software. III-V heterostructure (InGaAs/Si) and extended gate geometry provide increased tunneling probability, improved gate control, high \text{I}_{ON}/\text{I}_{OFF} ratio, and ultra-high sensitivity, compared to IV-IV heterostructure biosensors. The sensitivities of the biosensors are analyzed for both neutral and charged biomolecules, with dielectric constants \text{K}=5 ,7,10,12. Effect of non-ideal issues on sensitivity, such as temperature fluctuation, steric hindrance are also studied for the biosensors mentioned above. Benchmarking is done to provide a quantitative comparison of the proposed biosensor with published literature. A maximum sensitivity of 1.3\times 10^{8} , along with the \text{I}_{ON}/\text{I}_{OFF} ratio of 2\times 10^{12} and SS of 25.4 mV/V is noticed in SC-DM-EG HTFET for the dielectric constant of \text{K}=12 in a completely filled cavity of neutral biomolecules.
doi_str_mv 10.1109/JSEN.2020.3033576
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High sensitivity and fast detection of biomolecules are still a challenge for researchers. In this article, single cavity dual-material extended gate heterostructure (III-V) TFET (SC-DM-EG HTFET) based dielectrically modulated label-free biosensor is proposed; which promises higher sensitivity and better device performances such as, ON current, <inline-formula> <tex-math notation="LaTeX">\text{I}_{ON}/\text{I}_{OFF} </tex-math></inline-formula>ratio, subthreshold swing (SS); compared with single cavity dual-material heterostructure TFET (SC-DM HTFET), dual cavity dual-material heterostructure TFET (DC-DM HTFET), as well as, previously proposed FET based biosensors. 2D numerical simulation of the biosensors was performed with SILVACO ATLAS 2D simulation software. III-V heterostructure (InGaAs/Si) and extended gate geometry provide increased tunneling probability, improved gate control, high <inline-formula> <tex-math notation="LaTeX">\text{I}_{ON}/\text{I}_{OFF} </tex-math></inline-formula>ratio, and ultra-high sensitivity, compared to IV-IV heterostructure biosensors. The sensitivities of the biosensors are analyzed for both neutral and charged biomolecules, with dielectric constants <inline-formula> <tex-math notation="LaTeX">\text{K}=5 </tex-math></inline-formula>,7,10,12. Effect of non-ideal issues on sensitivity, such as temperature fluctuation, steric hindrance are also studied for the biosensors mentioned above. Benchmarking is done to provide a quantitative comparison of the proposed biosensor with published literature. A maximum sensitivity of <inline-formula> <tex-math notation="LaTeX">1.3\times 10^{8} </tex-math></inline-formula>, along with the <inline-formula> <tex-math notation="LaTeX">\text{I}_{ON}/\text{I}_{OFF} </tex-math></inline-formula>ratio of <inline-formula> <tex-math notation="LaTeX">2\times 10^{12} </tex-math></inline-formula>and SS of 25.4 mV/V is noticed in SC-DM-EG HTFET for the dielectric constant of <inline-formula> <tex-math notation="LaTeX">\text{K}=12 </tex-math></inline-formula> in a completely filled cavity of neutral biomolecules.]]></abstract><cop>New York</cop><pub>IEEE</pub><doi>10.1109/JSEN.2020.3033576</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6885-8220</orcidid><orcidid>https://orcid.org/0000-0002-9980-3916</orcidid><orcidid>https://orcid.org/0000-0002-1155-8400</orcidid></addata></record>
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subjects Biomolecules
biosensor
Biosensors
extended gate
Heterostructure TFET
Heterostructures
Indium gallium arsenides
label-free biosensing
Logic gates
Molecular biophysics
nanocavity
Performance evaluation
Permittivity
Sensitivity
Sensitivity analysis
Steric hindrance
TFETs
Tunneling
title Performance Evaluation of Dielectrically Modulated Extended Gate Single Cavity InGaAs/Si HTFET Based Label-Free Biosensor Considering Non-Ideal Issues
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